Results 1 to 10 of about 8,950,228 (359)

A novel atypical sperm centriole is functional during human fertilization. [PDF]

Nat Commun, 2018
The inheritance of the centrosome during human fertilization remains mysterious. Here we show that the sperm centrosome contains, in addition to the known typical barrel-shaped centriole (the proximal centriole, PC), a surrounding matrix (pericentriolar ...
Fishman EL, Jo K, Nguyen QPH, Kong D, Royfman R, Cekic AR, Khanal S, Miller AL, Simerly C, Schatten G, Loncarek J, Mennella V, Avidor-Reiss T.   +12 more
europepmc   +2 more sources

Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation. [PDF]

J Clin Invest
The infertility of many couples rests on an enigmatic dysfunction of the man’s sperm. To gain insight into the underlying pathomechanisms, we assessed the function of the sperm-specific multisubunit CatSper-channel complex in the sperm of almost 2,300 ...
Young S, Schiffer C, Wagner A, Patz J, Potapenko A, Herrmann L, Nordhoff V, Pock T, Krallmann C, Stallmeyer B, Röpke A, Kierzek M, Biagioni C, Wang T, Haalck L, Deuster D, Hansen JN, Wachten D, Risse B, Behre HM, Schlatt S, Kliesch S, Tüttelmann F, Brenker C, Strünker T.   +24 more
europepmc   +2 more sources

Human sperm ion channel (dys)function:implications for fertilization [PDF]

Human Reproduction Update, 2019
BACKGROUND: Intensive research on sperm ion channels has identified members of several ion channel families in both mouse and human sperm. Gene knock-out studies have unequivocally demonstrated the importance of the calcium and potassium conductances in ...
Barratt, Christopher L. R., Brown, Sean G., Martins da Silva, Sarah J., Publicover, Stephen J.   +3 more
core   +5 more sources

Epididymal epithelial cells facilitate NEU1 loading to modulate sperm α-2,6 sialylation, enhance maturation and motility [PDF]

Cellular and Molecular Life Sciences
Background Male infertility is a prevalent reproductive disorder worldwide, with decreased sperm quality—particularly reduced motility and fertilization capacity—being one of its common causes.
Shiqi Yi, Ruohan Wang, Yingchun Hu, Shukai Wang, Linyu Zhang, Xinrui Sun, Xin Yuan, Jiajie Li, Shuangling Zou, Hongxiang Wang, Fang Ma   +10 more
doaj   +2 more sources

Noninvasive chromosome screening of human embryos by genome sequencing of embryo culture medium for in vitro fertilization [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2016
Juanjuan Xu, Rui Fang, Li Chen, Daozhen Chen, Jianping Xiao, Weimin Yang, Honghua Wang, Xiaoqing Song, Ting Ma, Shiping Bo, Chong Shi, Jun Ren, Lei Huang, L. Cai, B. Yao, X. S. Xie, Sijia Lu   +16 more
semanticscholar   +2 more sources

Association of the Serum Folate and Total Calcium and Magnesium Levels Before Ovarian Stimulation With Outcomes of Fresh In Vitro Fertilization Cycles in Normogonadotropic Women

Frontiers in Endocrinology, 2022
BackgroundWomen of reproductive age are recommended to consume folic acid and other supplements before conception and during pregnancy. We aimed to investigate the association of the serum folate and total magnesium (Mg) and calcium (Ca) levels before ...
Mikhail Polzikov, Dmitry Blinov, Dmitry Blinov, Zarema Barakhoeva, Lyudmila Vovk, Yulia Fetisova, Maria Ovchinnikova, Marina Tischenko, Irina Zorina, Vasily Yurasov, Tatyana Ushakova, Tatyana Ushakova, Oleg Sergeyev   +12 more
doaj   +1 more source

Spermatogenic cell-specific SPACA4 is essential for efficient sperm-zona pellucida binding in vitro

Frontiers in Cell and Developmental Biology, 2023
Fertilization is a complex and highly regulated process that involves a series of molecular interactions between sperm and oocytes. However, the mechanisms of proteins involved in human fertilization, such as that of testis-specific SPACA4, remain poorly
Lin Chen, Junli Song, Jinglei Zhang, Zicong Luo, Xuren Chen, Canquan Zhou, Canquan Zhou, Canquan Zhou, Xiaoting Shen, Xiaoting Shen, Xiaoting Shen   +10 more
doaj   +1 more source

Gene mutations associated with fertilization failure after in vitro fertilization/intracytoplasmic sperm injection

Frontiers in Endocrinology, 2022
Fertilization failure during assisted reproductive technologies (ART) is often unpredictable, as this failure is encountered only after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) have been performed.
Yamei Xue, Xiaohong Cheng, Yuping Xiong, Kun Li, Kun Li   +4 more
doaj   +1 more source

The role of spermatozoa-zona pellucida interaction in selecting fertilization-competent spermatozoa in humans

Frontiers in Endocrinology, 2023
Human fertilization begins when a capacitated spermatozoon binds to the zona pellucida (ZP) surrounding a mature oocyte. Defective spermatozoa-ZP interaction contributes to male infertility and is a leading cause of reduced fertilization rates in ...
Erica T. Y. Leung, Brayden K. M. Lee, Cheuk-Lun Lee, Cheuk-Lun Lee, Xinyi Tian, Kevin K. W. Lam, Kevin K. W. Lam, Raymond H. W. Li, Raymond H. W. Li, Ernest H. Y. Ng, Ernest H. Y. Ng, William S. B. Yeung, Jian-Ping Ou, Jian-Ping Ou, Philip C. N. Chiu, Philip C. N. Chiu   +15 more
doaj   +1 more source

Identification of Novel Mutations in CDC20: Expanding the Mutational Spectrum for Female Infertility

Frontiers in Cell and Developmental Biology, 2021
Oocyte maturation and fertilization are fundamental processes for successful human reproduction, and abnormalities in these processes will cause infertility.
Lin Zhao, Lin Zhao, Yichun Guan, Qingxia Meng, Weijie Wang, Ling Wu, Biaobang Chen, Jijun Hu, Jiawei Zhu, Zhihua Zhang, Jian Mu, Yao Chen, Yiming Sun, Tianyu Wu, Wenjing Wang, Zhou Zhou, Jie Dong, Yang Zeng, Ruyi Liu, Qiaoli Li, Jing Du, Yanping Kuang, Qing Sang, Lei Wang   +23 more
doaj   +1 more source