Results 1 to 10 of about 8,808,045 (405)

A novel atypical sperm centriole is functional during human fertilization. [PDF]

Nat Commun, 2018
The inheritance of the centrosome during human fertilization remains mysterious. Here we show that the sperm centrosome contains, in addition to the known typical barrel-shaped centriole (the proximal centriole, PC), a surrounding matrix (pericentriolar ...
Fishman EL, Jo K, Nguyen QPH, Kong D, Royfman R, Cekic AR, Khanal S, Miller AL, Simerly C, Schatten G, Loncarek J, Mennella V, Avidor-Reiss T.   +12 more
europepmc   +2 more sources

Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation. [PDF]

J Clin Invest
The infertility of many couples rests on an enigmatic dysfunction of the man’s sperm. To gain insight into the underlying pathomechanisms, we assessed the function of the sperm-specific multisubunit CatSper-channel complex in the sperm of almost 2,300 ...
Young S, Schiffer C, Wagner A, Patz J, Potapenko A, Herrmann L, Nordhoff V, Pock T, Krallmann C, Stallmeyer B, Röpke A, Kierzek M, Biagioni C, Wang T, Haalck L, Deuster D, Hansen JN, Wachten D, Risse B, Behre HM, Schlatt S, Kliesch S, Tüttelmann F, Brenker C, Strünker T.   +24 more
europepmc   +2 more sources

Human sperm ion channel (dys)function: implications for fertilization [PDF]

Human Reproduction Update, 2019
BACKGROUND Intensive research on sperm ion channels has identified members of several ion channel families in both mouse and human sperm. Gene knock-out studies have unequivocally demonstrated the importance of the calcium and potassium conductances in ...
Sean G Brown, S. Publicover, C. Barratt, S. J. Martins da Silva   +3 more
semanticscholar   +5 more sources

Association of the Serum Folate and Total Calcium and Magnesium Levels Before Ovarian Stimulation With Outcomes of Fresh In Vitro Fertilization Cycles in Normogonadotropic Women

Frontiers in Endocrinology, 2022
BackgroundWomen of reproductive age are recommended to consume folic acid and other supplements before conception and during pregnancy. We aimed to investigate the association of the serum folate and total magnesium (Mg) and calcium (Ca) levels before ...
Mikhail Polzikov, Dmitry Blinov, Dmitry Blinov, Zarema Barakhoeva, Lyudmila Vovk, Yulia Fetisova, Maria Ovchinnikova, Marina Tischenko, Irina Zorina, Vasily Yurasov, Tatyana Ushakova, Tatyana Ushakova, Oleg Sergeyev   +12 more
doaj   +1 more source

Spermatogenic cell-specific SPACA4 is essential for efficient sperm-zona pellucida binding in vitro

Frontiers in Cell and Developmental Biology, 2023
Fertilization is a complex and highly regulated process that involves a series of molecular interactions between sperm and oocytes. However, the mechanisms of proteins involved in human fertilization, such as that of testis-specific SPACA4, remain poorly
Lin Chen, Junli Song, Jinglei Zhang, Zicong Luo, Xuren Chen, Canquan Zhou, Canquan Zhou, Canquan Zhou, Xiaoting Shen, Xiaoting Shen, Xiaoting Shen   +10 more
doaj   +1 more source

The role of spermatozoa-zona pellucida interaction in selecting fertilization-competent spermatozoa in humans

Frontiers in Endocrinology, 2023
Human fertilization begins when a capacitated spermatozoon binds to the zona pellucida (ZP) surrounding a mature oocyte. Defective spermatozoa-ZP interaction contributes to male infertility and is a leading cause of reduced fertilization rates in ...
Erica T. Y. Leung, Brayden K. M. Lee, Cheuk-Lun Lee, Cheuk-Lun Lee, Xinyi Tian, Kevin K. W. Lam, Kevin K. W. Lam, Raymond H. W. Li, Raymond H. W. Li, Ernest H. Y. Ng, Ernest H. Y. Ng, William S. B. Yeung, Jian-Ping Ou, Jian-Ping Ou, Philip C. N. Chiu, Philip C. N. Chiu   +15 more
doaj   +1 more source

Gene mutations associated with fertilization failure after in vitro fertilization/intracytoplasmic sperm injection

Frontiers in Endocrinology, 2022
Fertilization failure during assisted reproductive technologies (ART) is often unpredictable, as this failure is encountered only after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) have been performed.
Yamei Xue, Xiaohong Cheng, Yuping Xiong, Kun Li, Kun Li   +4 more
doaj   +1 more source

Identification of Novel Mutations in CDC20: Expanding the Mutational Spectrum for Female Infertility

Frontiers in Cell and Developmental Biology, 2021
Oocyte maturation and fertilization are fundamental processes for successful human reproduction, and abnormalities in these processes will cause infertility.
Lin Zhao, Lin Zhao, Yichun Guan, Qingxia Meng, Weijie Wang, Ling Wu, Biaobang Chen, Jijun Hu, Jiawei Zhu, Zhihua Zhang, Jian Mu, Yao Chen, Yiming Sun, Tianyu Wu, Wenjing Wang, Zhou Zhou, Jie Dong, Yang Zeng, Ruyi Liu, Qiaoli Li, Jing Du, Yanping Kuang, Qing Sang, Lei Wang   +23 more
doaj   +1 more source

Identification of Sialyl-Lewis(x)-Interacting Protein on Human Spermatozoa

Frontiers in Cell and Developmental Biology, 2021
Capacitated spermatozoa initiate fertilization by binding to the zona pellucida (ZP). Defective spermatozoa-ZP binding causes infertility. The sialyl-Lewis(x) (SLeX) sequence is the most abundant terminal sequence on the glycans of human ZP glycoproteins
Ying Wang, Ying Wang, Weie Zhao, Weie Zhao, Si Mei, Si Mei, Panyu Chen, Tsz-Ying Leung, Tsz-Ying Leung, Cheuk-Lun Lee, Cheuk-Lun Lee, William S. B. Yeung, William S. B. Yeung, Jian-Ping Ou, Jian-Ping Ou, Xiaoyan Liang, Philip C. N. Chiu, Philip C. N. Chiu   +17 more
doaj   +1 more source

Studying Human Fertility [PDF]

Environmental Health Perspectives, 2004
We very much welcome the National Children’s Study, which promises to raise the study of factors affecting reproduction and development to a new level. An impressive and exciting range of new methodologies is being developed (Chapin and Buck 2004; National Children’s Study 2004).
Jane Key, Michael Joffe, Tina Kold Jensen, Nicky Best   +3 more
openaire   +3 more sources