Results 81 to 90 of about 305,098 (258)

Embryos as Patients? Medical Provider Duties in the Age of CRISPR/Cas9 [PDF]

, 2017
The CRISPR/Cas9 genome engineering platform is the first method of gene editing that could potentially be used to treat genetic disorders in human embryos. No past therapies, genetic or otherwise, have been intended or used to treat disorders in existent
Powell, G. Edward, III
core   +1 more source

Conserved genes regulating human sex differentiation, gametogenesis and fertilization

Journal of Translational Medicine
The study of the functional genome in mice and humans has been instrumental for describing the conserved molecular mechanisms regulating human reproductive biology, and for defining the etiologies of monogenic fertility disorders.
Khalid A. Fakhro, Johnny Awwad, Suma Garibova, Luis R. Saraiva, Matteo Avella   +4 more
doaj   +1 more source

Depletion of human serum albumin in embryo culture media for in vitro fertilization using monolithic columns with immobilized antibodies

, 2016
Irina A. Tarasova, Anna A. Lobas, Urh Černigoj, Elizaveta M. Solovyeva, Barbara Mahlberg, Mark V. Ivanov, Tanja Panić‐Janković, Zoltán Nagy, M. L. Pridatchenko, András Pungor, Blaž Nemec, Urška Vidic, Jernej Gašperšič, Nika Lendero Krajnc, Jana Vidič, Mikhail V. Gorshkov, Goran Mitulović   +16 more
openalex   +2 more sources

Cited2 protein level in cumulus cells is a biomarker for human embryo quality and pregnancy outcome in one in vitro fertilization cycle [PDF]

, 2016
Yuan Fang, Wei Shang, De-Li Wei, Shenming Zeng   +3 more
openalex   +1 more source

Additional file 6 of RNA-Seq transcriptome reveals different molecular responses during human and mouse oocyte maturation and fertilization

, 2020
Zheng‐Hui Zhao, Tie‐Gang Meng, Ang Li, Heide Schatten, Zhen‐Bo Wang, Qing‐Yuan Sun   +5 more
openalex   +1 more source

Both low and high serum progesterone levels on the day of human chorionic gonadotrophin (hCG) administration reduce live-birth rates during in-vitro fertilization (IVF/ICSI) [PDF]

, 2013
Samuel Santos‐Ribeiro, N. P. Polyzos, Herman Tournaye, Christophe Blockeel   +3 more
openalex   +1 more source

Age-associated aberrations of the cumulus-oocyte interaction and in the zona pellucida structure reduce fertility in female mice

Communications Biology
, One of the major age-related declines in female reproductive function is the reduced quantity and quality of oocytes. Here we demonstrate that structural changes in the zona pellucida (ZP) were associated with decreased fertilization rates from 34- to ...
Yu Ishikawa-Yamauchi, Chihiro Emori, Hideto Mori, Tsutomu Endo, Kiyonori Kobayashi, Yuji Watanabe, Hiroshi Sagara, Takeshi Nagata, Daisuke Motooka, Akinori Ninomiya, Manabu Ozawa, Masahito Ikawa   +11 more
doaj   +1 more source

A novel atypical sperm centriole is functional during human fertilization. [PDF]

Nat Commun, 2018
Fishman EL, Jo K, Nguyen QPH, Kong D, Royfman R, Cekic AR, Khanal S, Miller AL, Simerly C, Schatten G, Loncarek J, Mennella V, Avidor-Reiss T.   +12 more
europepmc   +1 more source

Carnitine traffic and human fertility

Biochemical Pharmacology
Carnitine is a vital molecule in human metabolism, prominently involved in fatty acid β-oxidation within mitochondria. Predominantly sourced from dietary intake, carnitine also derives from endogenous synthesis. This review delves into the complex network of carnitine transport and distribution, emphasizing its pivotal role in human fertility. Together
Mazza, Tiziano, Scalise, Mariafrancesca, Console, Lara, Galluccio, Michele, Giangregorio, Nicola, Tonazzi, Annamaria, Pochini, Lorena, Indiveri, Cesare   +7 more
openaire   +3 more sources

Author Correction: A novel atypical sperm centriole is functional during human fertilization. [PDF]

Nat Commun, 2018
Fishman EL, Jo K, Nguyen QPH, Kong D, Royfman R, Cekic AR, Khanal S, Miller AL, Simerly C, Schatten G, Loncarek J, Mennella V, Avidor-Reiss T.   +12 more
europepmc   +1 more source