Results 101 to 110 of about 1,575,758 (358)
A comparative study of endoderm differentiation in humans and chimpanzees
Genome Biology, 2018 Background There is substantial interest in the evolutionary forces that shaped the regulatory framework in early human development. Progress in this area has been slow because it is difficult to obtain relevant biological samples.
Lauren E. Blake +7 more
doaj +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Proteomic profiling of the plasma of Gambian children with cerebral malaria
Malaria Journal, 2018 Background Cerebral malaria (CM) is a severe neurological complication of Plasmodium falciparum infection. A number of pathological findings have been correlated with pediatric CM including sequestration, platelet accumulation, petechial haemorrhage and ...
Ehab M. Moussa +10 more
doaj +1 more source
A parasitological view of non-constructible sets [PDF]
, 2010 The genetic code, the primary manifestation of life, and, on the other hand, language, the universal endowment of humanity and its momentous leap from genetics to civilization, are the two fundamental stores of information transmissible from the ancestry
Kortlandt, Frederik H. H.
core
Admixture Correction in the Outgroup-f3 Statistic [PDF]
, 2018 Genetic inheritance can be studied within a purely genetic scope. However, this eliminates part of the picture. The field of genetics is often thought of as a natural science with little in common with fields of social science. However, in human genetics
Tunga, Nita
core +1 more source
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
eLifeAsthenoteratozoospermia, a prevalent cause of male infertility, lacks a well-defined etiology. DNAH12 is a special dynein featured by the absence of a microtubule-binding domain, however, its functions in spermatogenesis remain largely unknown.
Menglei Yang +20 more
doaj +1 more source
Journal of Assisted Reproduction and Genetics, 1998 Chromosome abnormalities in sperm were studied by fluorescence in situ hybridization to determine the frequency and distribution of abnormalities in normal men and the effect of donor age on the frequency of abnormalities. Studies of chemotherapy and infertility patients assessed any increased risk in these populations.Multicolor fluorescence in situ ...
openaire +3 more sources
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Journal of Lipid Research, 2020 Accompanied with nutrition transition, non-HDL-C levels of individuals in Asian countries has increased rapidly, which has caused the global epicenter of nonoptimal cholesterol to shift from Western countries to Asian countries.
Shaofeng Huo +7 more
doaj +1 more source