Results 181 to 190 of about 1,645,811 (308)

Fifteen Years of PNPLA3: Transforming Hepatology Through Human Genetics. [PDF]

Liver Int
Romeo S, Valenti L.
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Human genetics of Whipple's disease. [PDF]

Curr Opin Rheumatol
Rosain J, Casanova JL, Bustamante J.
europepmc   +1 more source

Gender, genes and genetics: from Darwin to the human genome [PDF]

, 2000
Segal, Lynne
core  

Recent advances in array comparative genomic hybridization technologies and their applications in human genetics [PDF]

, 2005
William W. Lockwood, Raj Chari, Bryan Chi, Wan L. Lam   +3 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Recognising Contemporary Determinants of Public Health: human rights, armed conflict and genetics [PDF]

, 2011
F. Sim, Rosemary Martyn, Abie Longstaff, Benjamin Roberts, David L. Swerdlow, Mark Holmes, Martin McKee   +6 more
openalex  

Putting the ‘Human’ Back in Genetics: Modeling the Extended Kinships of Twins [PDF]

, 2009
Lindon J. Eaves
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Using human genetics to understand the epidemiological association between child obesity at different ages and MASLD. [PDF]

Int J Surg
Ge Q, Zhang L, Cai J, Sun Z, Yu C, Liu Z, Xiao C.   +6 more
europepmc   +1 more source