Results 201 to 210 of about 1,631,641 (306)

Human Genetics, Natriuretic Peptides and Hypertension [PDF]

, 2013
Newton-Cheh, Christopher Holmes
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Human genetics and genomics as a unifying factor for harmony and progress in Africa: a report from the 12^th African Society of Human Genetics meeting in Bamako, Mali. [PDF]

Pan Afr Med J
Yalcouyé A, Dabitao D, Samassékou O, Nembaware V, Kané F, Alimohamed MZ, El-Kamah G, Mutesa L, Ndiaye R, Ramsay M, Doumbia S, Williams S, Traoré M, Wonkam A, Landouré G.   +14 more
europepmc   +1 more source

Human Genetics and Genomic Medicine [PDF]

, 2012
Doerfel, Max, Kota, Prashant, Lyon, Gholson J., O'Rawe, Jason, Wu, Yiyang   +4 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Human genetics of metabolic dysfunction-associated steatotic liver disease: from variants to cause to precision treatment. [PDF]

J Clin Invest
Chen VL, Kuppa A, Oliveri A, Chen Y, Ponnandy P, Patel PB, Palmer ND, Speliotes EK.   +7 more
europepmc   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Using human genetics to understand the epidemiological association between neuroticism and lung cancer. [PDF]

Transl Lung Cancer Res
Wu D, Liu Y, Liu S, Hao X, Li X, Zheng Q, Wang T, Huang Y, Wei S, Zhou J, Liu L.   +10 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Human genetics and epigenetics of alcohol use disorder. [PDF]

J Clin Invest
Zhou H, Gelernter J.
europepmc   +1 more source