Results 211 to 220 of about 884,084 (316)

Human Genetics -- Learning for the Millennium and Beyond: Proceedings of the Human Genetics Advisory Commission's First National Conference at the Royal Society on 16 October 1998

, 1999
Human Genetics Advisory Commission [HGAC] (Great Britain)
core  

Multifaceted disruption of AMPA receptor signaling by <i>CACNG8</i> variants: Integrated evidence from human genetics and molecular simulation. [PDF]

Comput Struct Biotechnol J
Alibrandi S, Mordà D, Scimone C, Abate G, Chust IB, Rinaldi C, Poggi L, Scalinci SZ, D'Angelo R, Sidoti A, Donato L.   +10 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Letter to members of the European Parliament from the European Society of Human Genetics. Re: Fiori Report on the ethical, legal, economic and social implications of human genetics

, 2001
European Society of Human Genetics [ESHG]
core  

Human genetics of metabolic dysfunction-associated steatotic liver disease: from variants to cause to precision treatment. [PDF]

J Clin Invest
Chen VL, Kuppa A, Oliveri A, Chen Y, Ponnandy P, Patel PB, Palmer ND, Speliotes EK.   +7 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Human genetics and epigenetics of alcohol use disorder. [PDF]

J Clin Invest
Zhou H, Gelernter J.
europepmc   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Using human genetics to understand the epidemiological association between neuroticism and lung cancer. [PDF]

Transl Lung Cancer Res
Wu D, Liu Y, Liu S, Hao X, Li X, Zheng Q, Wang T, Huang Y, Wei S, Zhou J, Liu L.   +10 more
europepmc   +1 more source