Results 211 to 220 of about 1,575,758 (358)

Abstracts of Papers Communicated at the 23rd Annual Meeting of the Japan Society of Human Genetics, 1978 [PDF]

, 1979

openalex   +1 more source

Human genetics of metabolic dysfunction-associated steatotic liver disease: from variants to cause to precision treatment. [PDF]

J Clin Invest
Chen VL, Kuppa A, Oliveri A, Chen Y, Ponnandy P, Patel PB, Palmer ND, Speliotes EK.   +7 more
europepmc   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Using human genetics to understand the epidemiological association between neuroticism and lung cancer. [PDF]

Transl Lung Cancer Res
Wu D, Liu Y, Liu S, Hao X, Li X, Zheng Q, Wang T, Huang Y, Wei S, Zhou J, Liu L.   +10 more
europepmc   +1 more source

Future prospects for human genetics and genomics in drug discovery. [PDF]

Curr Opin Struct Biol, 2023
Ghoussaini M, Nelson MR, Dunham I.
europepmc   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Serologic identification of the human secondary B cell antigens. Correlations between function, genetics, and structure. [PDF]

, 1982
Stephen Shaw, Robert DeMars, S F Schlossman, Paula Smith, L A Lampson, Lee M. Nadler   +5 more
openalex   +1 more source

Application of Human Genetics to Prioritize Coagulation Cascade Protein Targets for Ischemic Stroke Prevention. [PDF]

Stroke
Daghlas I, Karhunen V, Kim AS, Gill D.
europepmc   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Quantitative genetics of human skin color [PDF]

, 1981
Pamela J. Byard
openalex   +1 more source