Results 231 to 240 of about 10,048,978 (405)

Human Genetics of Addiction: New Insights and Future Directions

open access: yesCurrent Psychiatry Reports, 2018
D. Hancock   +3 more
semanticscholar   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

open access: yesMolecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau   +9 more
wiley   +1 more source

Human genetics and genomics as a unifying factor for harmony and progress in Africa: a report from the 12th African Society of Human Genetics meeting in Bamako, Mali. [PDF]

open access: yesPan Afr Med J
Yalcouyé A   +14 more
europepmc   +1 more source

Measuring intolerance to mutation in human genetics

open access: yesNature Genetics, 2018
Zachary L. Fuller   +4 more
semanticscholar   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

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