Results 271 to 280 of about 10,048,978 (405)
Mendelian randomization as a tool to inform drug development using human genetics. [PDF]
Daghlas I, Gill D.
europepmc +1 more source
Symposium: Biotechology in Human Genetics—From Molecules to Whole Body [PDF]
Hiraku Takebe
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In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková+14 more
wiley +1 more source
75 years of The American Journal of Human Genetics. [PDF]
Korf BR.
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The role of single-cell genomics in human genetics. [PDF]
Sreenivasan VKA+2 more
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Molecular Genetics in the Study of Human Disease [PDF]
Josef Warkany+26 more
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In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim+11 more
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Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome. [PDF]
Li S+16 more
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Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez+5 more
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Abstracts of the Furuhata-Iseki Memorial Session, the 32nd Annual Meeting of the Japan Society of Human Genetics [PDF]
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