Results 41 to 50 of about 10,288,978 (312)

Human cancer genetics [PDF]

Journal of Zhejiang University SCIENCE B, 2006
The short report will be focused on the genetic basis and possible mechanisms of tumorigenesis, common types of cancer, the importance of genetic diagnosis of cancer, and the methodology of cancer genetic diagnosis. They will also review presymptomatic testing of hereditary cancers, and the application of expression profiling to identify patients ...
Marilyn, Li, Donna, Albertson
openaire   +2 more sources

A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes

Frontiers in Cardiovascular Medicine, 2021
Congenital heart disease (CHD) is the most common type of birth defect, affecting ~1% of all live births. Malformations of the cardiac outflow tract (OFT) account for ~30% of all CHD and include a range of CHDs from bicuspid aortic valve (BAV) to ...
Adrianna Matos-Nieves, Sathiyanarayanan Manivannan, Uddalak Majumdar, Kim L. McBride, Kim L. McBride, Peter White, Peter White, Vidu Garg, Vidu Garg, Vidu Garg   +9 more
doaj   +1 more source

Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome

Nature Medicine, 2022
The levels of the thousands of metabolites in the human plasma metabolome are strongly influenced by an individual’s genetics and the composition of their diet and gut microbiome.
Lianmin Chen, D. Zhernakova, A. Kurilshikov, S. Andreu-Sánchez, Daoming Wang, Hannah E. Augustijn, A. Vich Vila, R. Weersma, M. Medema, M. Netea, F. Kuipers, C. Wijmenga, A. Zhernakova, Jingyuan Fu   +13 more
semanticscholar   +1 more source

Staphylococcus aureus adaptive evolution: Recent insights on how immune evasion, immunometabolic subversion and host genetics impact vaccine development

Frontiers in Cellular and Infection Microbiology, 2022
Despite meritorious attempts, a S. aureus vaccine that prevents infection or mitigates severity has not yet achieved efficacy endpoints in prospective, randomized clinical trials. This experience underscores the complexity of host-S. aureus interactions,
Tania Wong Fok Lung, Liana C. Chan, Liana C. Chan, Liana C. Chan, Alice Prince, Michael R. Yeaman, Michael R. Yeaman, Michael R. Yeaman, Nathan K. Archer, M. Javad Aman, Richard A. Proctor   +10 more
doaj   +1 more source

Human and molecular genetics shed lights on fatty liver disease and diabetes conundrum

Endocrinology, Diabetes & Metabolism, 2020
The causal role of abdominal overweight/obesity, insulin resistance and type 2 diabetes (T2D) on the risk of fatty liver disease (FLD) has robustly been proven.
Federica Tavaglione, Giovanni Targher, Luca Valenti, Stefano Romeo   +3 more
doaj   +1 more source

Tinea Imbricata among the Indigenous Communities: Current Global Epidemiology and Research Gaps Associated with Host Genetics and Skin Microbiota

Journal of Fungi, 2022
Tinea imbricata is a unique fungal skin disease that mostly affects indigenous populations in Southeast Asia, Oceania, and Central and South America. The control and management of this disease among these communities are challenging given their remote ...
Yi Xian Er, Soo Ching Lee, Leslie Thian-Lung Than, Azdayanti Muslim, Kin Fon Leong, Zhenli Kwan, Izandis Mohd Sayed, Yvonne Ai-Lian Lim   +7 more
doaj   +1 more source

Morphometry and morphological analysis of carotico-clinoid foramen: an anatomical study with clinical implications

Folia Morphologica, 2023
BACKGROUND: The dural fold between anterior and middle clinoid processes on mineralisation leads to the formation of caroticoclinoid foramen (CCF). Different morphology of this foramen presents with different clinical features.
A. Priya, R. K. Narayan, S. K. Ghosh, P. Kumar   +3 more
doaj   +1 more source

Y chromosome damage underlies testicular abnormalities in ATR-X syndrome

iScience
Summary: ATR-X (alpha thalassemia, mental retardation, X-linked) syndrome features genital and testicular abnormalities including atypical genitalia and small testes with few seminiferous tubules. Our mouse model recapitulated the testicular defects when
Nayla Y. León, Thanh Nha Uyen Le, Andrew Garvie, Lee H. Wong, Stefan Bagheri-Fam, Vincent R. Harley   +5 more
doaj   +1 more source

Generation of Dual-Color FISH probes targeting 9p21, Xp21, and 17p13.1 loci as diagnostic markers for some genetic disorders and cancer in Egypt

Journal of Genetic Engineering and Biotechnology
Introduction: The fluorescence in situ hybridization (FISH) is a very important technique, as it can diagnose many genetic disorders and cancers. Molecular cytogenetic analysis (FISH) can diagnose numerical chromosome aberrations, sex chromosomes ...
Amal M. Mohamed, Maha Eid, Ola Eid, Shymaa H Hussein, Wael Mahmoud, Rana Mahrous, Khaled Refaat, Marwa Farid   +7 more
doaj   +1 more source

Human Genetics and Drug Development.

New England Journal of Medicine, 2019
Current tools in the field of human genetics can reliably estimate both the intended and the adverse effects of modifying a therapeutic target to guide the clinical development of medicines.1 The d...
M. Holmes
semanticscholar   +1 more source