Results 61 to 70 of about 825,099 (241)

A comparative study of endoderm differentiation in humans and chimpanzees

Genome Biology, 2018
Background There is substantial interest in the evolutionary forces that shaped the regulatory framework in early human development. Progress in this area has been slow because it is difficult to obtain relevant biological samples.
Lauren E. Blake, Samantha M. Thomas, John D. Blischak, Chiaowen Joyce Hsiao, Claudia Chavarria, Marsha Myrthil, Yoav Gilad, Bryan J. Pavlovic   +7 more
doaj   +1 more source

Construction and Functional Analysis of Human Genetic Interaction Networks with Genome-wide Association Data [PDF]

arXiv, 2011
Genetic interaction measures how different genes collectively contribute to a phenotype, and can reveal functional compensation and buffering between pathways under genetic perturbations. Recently, genome-wide screening for genetic interactions has revealed genetic interaction networks that provide novel insights either when analyzed by themselves or ...
arxiv  

Principles of Human Genetics

Population (French Edition), 1950
Includes bibliographies. ; Mode of access: Internet.
J. S., Curt Stern
openaire   +2 more sources

Population Fitness and Genetic Load of Single Nucleotide Polymorphisms Affecting mRNA splicing [PDF]

arXiv, 2011
Deleterious genetic variants can be evaluated as quantitative traits using information theory-based sequence analysis of recognition sites. To assess the effect of such variants, fitness and genetic load of SNPs which alter binding site affinity are derived from changes in individual information and allele frequencies.
arxiv  

PhysicsGP: A Genetic Programming Approach to Event Selection [PDF]

, 2004
We present a novel multivariate classification technique based on Genetic Programming. The technique is distinct from Genetic Algorithms and offers several advantages compared to Neural Networks and Support Vector Machines. The technique optimizes a set of human-readable classifiers with respect to some user-defined performance measure.
arxiv   +1 more source

Y chromosome damage underlies testicular abnormalities in ATR-X syndrome

iScience
Summary: ATR-X (alpha thalassemia, mental retardation, X-linked) syndrome features genital and testicular abnormalities including atypical genitalia and small testes with few seminiferous tubules. Our mouse model recapitulated the testicular defects when
Nayla Y. León, Thanh Nha Uyen Le, Andrew Garvie, Lee H. Wong, Stefan Bagheri-Fam, Vincent R. Harley   +5 more
doaj  

History of medical genetics in South Africa

Journal of the Colleges of Medicine of South Africa
No abstract available.
Jennifer G. Kromberg, Grietje de Jong
doaj   +1 more source

Environmental Disorder Regulation of Invasion and Genetic Loss [PDF]

arXiv, 2019
Many physical and natural systems, including the population of species, evolve in habitats with spatial stochastic variations of the individuals' motility. We study here the effect of those fluctuations on invasion and genetic loss. A Langevin equation for the \textit{position} and \textit{border} of the invasion front is obtained. A striking result is
arxiv  

Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice

eLife
Asthenoteratozoospermia, a prevalent cause of male infertility, lacks a well-defined etiology. DNAH12 is a special dynein featured by the absence of a microtubule-binding domain, however, its functions in spermatogenesis remain largely unknown.
Menglei Yang, Hafiz Muhammad Jafar Hussain, Manan Khan, Zubair Muhammad, Jianteng Zhou, Ao Ma, Xiongheng Huang, Jingwei Ye, Min Chen, Aoran Zhi, Tao Liu, Ranjha Khan, Ali Asim, Wasim Shah, Aurang Zeb, Nisar Ahmad, Huan Zhang, Bo Xu, Hui Ma, Qinghua Shi, Baolu Shi   +20 more
doaj   +1 more source

Genetics of Human Growth

Clinical Pediatric Endocrinology, 2006
Genes involved in human growth consist of major growth genes and minor growth genes. Major growth genes have fundamental effects on human growth, and their mutations cause growth failure (or overgrowth) which are recognizable as single gene disorders.
openaire   +4 more sources