Results 91 to 100 of about 908,738 (290)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Yeast: one cell, one reference sequence, many genomes?

New Genetics and Society, 2019
The genome of Saccharomyces cerevisiae – brewer’s or baker’s yeast – was the first eukaryotic genome to be sequenced in 1996. The identity of that yeast genome has been not just a product of sequencing, but also of its use after sequencing and ...
Erika Szymanski, Niki Vermeulen, Mark Wong   +2 more
doaj   +1 more source

The International Human Genome Project. [PDF]

Hum Mol Genet, 2021
Birney E.
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Big data, open science and the brain: lessons learned from genomics

Frontiers in Human Neuroscience, 2014
The BRAIN Initiative aims to break new ground in the scale and speed of data collection in neuroscience, requiring tools to handle data in the magnitude of yottabytes (1024).
Suparna eChoudhury, Jennifer eFishman, Michelle eMcGowan, Eric eJuengst   +3 more
doaj   +1 more source

History, philosophy, and science education: reflections on genetics 20 years after the human genome project. [PDF]

Hist Philos Life Sci, 2023
Meunier R.
europepmc   +1 more source

Misclassification of a whole genome sequence reference defined by the Human Microbiome Project: a detrimental carryover effect to microbiome studies [PDF]

, 2019
DJ Darwin R. Bandoy, Bihua C. Huang, Bart C. Weimer   +2 more
openalex   +1 more source

Stealing the riches: using the human genome project for livestock research [PDF]

, 2002
The document attached has been archived with permission from the Australian Association of Cattle Veterinarians.The human genome project has brought a new era not only to medical genetics, but also to livestock molecular genetics.
Bottema, C.
core  

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The Human Genome Project (HGP): Dividends and challenges: A review

International Journal of Medicine and Health Development, 2010
Background: Many disorders in man have been described as genetic or hereditary in nature and have defied absolute medical treatment and cure. Genomic studies have given profound insights into the genetic organization of many organisms including man.
F E Ejezie
doaj   +1 more source