Results 101 to 110 of about 549,507 (300)
Integrative annotation of 21,037 human genes validated by full-length cDNA clones
, 2004 The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited.Terwilliger Joseph D, Nagata, Naoki, Kuryshev, Vladimir, Eveno, E., Imbeaud, S., Makalowski, W., Yoshiyuki Suzuki, Sakai, Katsunaga, Graudens Esther, de Souza, S.J., Sakamoto Shigetaka, Thomas, M.A., Ashurst, Jennifer, Kanehisa Minoru, Shinsei Minoshima, Korn, B., Mitsuteru Nakao, Robert L Strausberg, Unneberg, P., Eveno Eric, Ren, S. -X, Lenhard, B., Shiba, Rie, Hilton Phillip, Sakate, Ryuichi, Bromberg Susan K, Gopal R. Gopinath, Nakai, K., Jia, Libin, Alexander Kanapin, Momoki Hirai, Barrero, R., Strausberg Robert L, Steward Charles, Suzuki, Yutaka, Okazaki, Yasushi, Makalowski Wojciech, Okido Toshihisa, Fukami-Kobayashi Kaoru, Satoshi Oota, Motohiko Tanino, Hide, Winston, R. Gopinath, Gopal, Auffray, C., de Souza, S., Shimoyama, Mary, Dubchak Inna, Osamu Ogasawara, Erimi Harada, Quackenbush, John, Jun-ichi Takeda, Steward, C., Kikuno, Reiko, Hirai, M., Isogai, T., Piero Carninci, Matsuda, Hideo, Ryuichi Sakate, Suzuki Yutaka, Kenta Nakai, Chen Zhu, Hiroaki Sakai, Shiba, R., Okubo, K., Nomura Nobuo, Sandro J. de Souza, Taylor Todd, Toshihisa Takagi, Thierry-Mieg Jean, Fukuchi Satoshi, Nagasaki, H., Hayashizaki, Yoshihide, Bellgard Matthew, Chelala Claude, Terwilliger, J., Bruford Elspeth, Apweiler Rolf, Christine Couillault, Takeya Kasukawa, Suzuki Mami, Nobuo Nomura, Sakai Katsunaga, Korn, Bernhard, Mulder, N., Amid, Clara, Schupp, Ingo, Kasukawa Takeya, Veeramachaneni, V., Wagner, L., Yura Kei, Annemarie Poustka, Yura, Kei, Ian Hopkinson, Hashimoto, Katsuyuki, Bono, H., Endo, T., Couillault, Christine, Elspeth Bruford, Bono Hidemasa, Ota Toshio, Reiko Kikuno, O'Donovan, C., Ota, M., Jia, L., Han Michael, Okazaki, Y., Shuang-Xi Ren, Tamura, T., Sakamoto, S., Bromberg, Susan K., Ohara, Osamu, Korn Bernhard, Hyang-Yoo, S., Nagata, N., Karavidopoulou Youla, Koyanagi, K.O., Soares, Bento, Tanaka, H., Charles Steward, Yamasaki, Chisato, Saitou Naruya, Yoo, H-S, Norikazu Yasuda, Imbeaud, Sandrine, Roberto A Barrero, Nishikawa Tetsuo, Izabela Makalowska, Jin Lihua, Nigam, Rajni, Gopinath, G. R., Motonori Ota, Stephen Sherry, Hiroshi Tanaka, Yayoi Kaneko, Jean Thierry-Mieg, Okada, Norihiro, Kelso, J. ; https://orcid.org/, Fukami-Kobayashi, K., Otsuki, Tetsuji, Yura, K., Ikeo, K., Hanaoka, Hideki, Rajni Nigam, Tanino, Motohiko, Sugano Sumio, Matthew Bellgard, Kaoru Fukami-Kobayashi, Oota Satoshi, Shimizu, Nobuyoshi, Sugano, Sumio, Satoshi Fukuchi, O'Donovan, Claire, Ren, S-X, Todd Taylor, Kimura Kouichi, Bonaldo, Maria de Fatima, Poustka, Annemarie, Koyanagi, K., Shimizu, N., Kanapin Alexander, Bono, Hidemasa, Chelala, Claude, Koyanagi, Kanako O., Devignes, M. -D, Stodolsky, M., Brookes, A., Strausberg, R., Danielle Thierry-Mieg, Stefan Wiemann, Eyras, Eduardo, Brookes, Anthony J., Mami Suzuki, Lukas Wagner, Hilton, Phillip, Barrero Roberto A, Suzuki Yoshiyuki, Sugawara Hideaki, Kasukawa, T., Yoshihide Hayashizaki, Mano, Shuhei, Craig Gough, Takashi Makino, Takahashi, Aiko, Shuhei Mano, Takashi Gojobori, Suzuki, Yoshiyuki, Libin Jia, Kousaku Okubo, Han, Michael, Koyanagi Kanako O, Hidemasa Bono, Inoko, Hidetoshi, Hinz Ursula, Auffray Charles, Strausberg, R.L., Yamaguchi-Kabata, Y., Devignes, Marie Dominique, Norihiro Okada, Hideki Hanaoka, Oota, S., Fujii Yasuyuki, Han, Ze-Guang, Isogai Takao, Kasprzyk, A., Ranajit Chakraborty, Itoh, Takeshi, Terwilliger, Joseph D., Florence Servant, Mulder, Nicola, Takahashi, A., Piatier-Tonneau, Dominique, Hirakawa Mika, R. Gopinath, G., Bromberg, S., Hinz, Ursula, Suwa Makiko, Hopkinson, I., Thierry-Mieg Danielle, Chelala, C., Mewes, Hans Werner, Amid, C., Hirakawa, Mika, Servant, Florence, Hishiki, T., Nomura, N., Steward, Charles, Tamiya, G., Rie Shiba, Hahn Yoonsoo, Fujii, Y., Tateno Yoshio, Sugawara, H., Ren, Shuang Xi, Naoki Nagata, Soares Bento, Hidetoshi Inoko, Sakai, H., Schupp, I., Sakamoto, Shigetaka, Lenhard Boris, Yasuda Norikazu, Nakai Kenta, Kim, S., Kersey Paul, Watanabe Shinya, de Bonaldo, M., Hishiki, Teruyoshi, Mariage-Samson, R., Toshinori Endo, Hishiki Teruyoshi, Bellgard, Matthew, Mano, S., Nishikawa, Tetsuo, Okido, T., Wiemann, S., Anne Estreicher, Hayashizaki, Y., Miyazaki, Satoru, Susan K Bromberg, Apweiler, R., Katsunaga Sakai, Han, M., Oishi Michio, Hide, W., Kanako O Koyanagi, Tetsuo Nishikawa, Nobuyoshi Shimizu, Carninci, Piero, Makino Takashi, Dubchak, Inna, Yoo, Hyang-Sook, Ren, S., Strausberg, R. L., Estreicher, A., Yamasaki Chisato, Eyras, E., Tanaka Hiroshi, Nagai, Keiichi, Wilming, Laurens, Phillip Hilton, Ota, T., Go, M., Wilming Laurens, Winston Hide, Hopkinson Ian, Yasuda, Norikazu, Graudens, Esther, Regine Mariage-Samson, Harada, Erimi, Suwa, Makiko, Claude Chelala, Sherry Stephen, Yamaguchi-Kabata, Yumi, Eduardo Eyras, Han, Z. -G, Chakraborty, Ranajit, Teruyoshi Hishiki, Yoo, H-S., Mariage-Samson, Regine, Piatier-Tonneau Dominique, Kim, Sangsoo, Takeda, Jun Ichi, Bento Soares, Poustka, A., Zhu Chen, Makalowska, Izabela, Okada, N., Youla Karavidopoulou, Amid Clara, Suzuki, M., Sakai, K., Unneberg, Per, Wiemann Stefan, Inna Dubchak, Taylor, T., Okido, Toshihisa, Charles Auffray, Kelso, J., Hirai Momoki, Jennifer Ashurst, Yasuyuki Fujii, Nigam, R., Nishikawa, Ken, Terwilliger, J.D., Gopal R Gopinath, Tetsuji Otsuki, Nakao Mitsuteru, Brookes Anthony J, Hahn, Y., Simpson, A.J., Debily, Marie-Anne, Sangsoo Kim, Imanishi Tadashi, Homma, Keiichi, Kasukawa, Takeya, Makalowska Izabela, Takeda, J-I, Yutaka Suzuki, Jin, Lihua, Terwilliger, J. D., Aiko Takahashi, Hyang-Yoo, Sook, Sakai Hiroaki, Shimizu Nobuyoshi, Michael A Thomas, Tadashi Imanishi, Esther Graudens, Paul Kersey, Stodolsky Marvin, Toshio Ota, Ren, Shuang-Xi, Carninci Piero, Tanaka, S., Imanishi, T., Yoshio Tateno, Simpson Andrew J, de Fatima Bonaldo, Maria, Yoo Hyang-Sook, Imbeaud Sandrine, Brookes, A.J., Kikuno Reiko, Tanaka, Susumu, Tamiya, Gen, de Souza Sandro J., Sugano, S., Tomohiro Yasuda, Wilming, L., Keiichi Nagai, Devignes, Marie-Dominique, Matsuda Hideo, Takeda, J. -I, Nishikawa, T., Thierry-Mieg, J., Hideki Nagasaki, Estreicher Anne, Harada, E., Ota, Toshio, Yumi Yamaguchi-Kabata, Kelso, Janet, Minoshima Shinsei, Tanaka, Hiroshi, Kimura, K., Ingo Schupp, Sumio Sugano, Piatier-Tonneau, D., Yasuda, T., Simpson, A. J., Minoru Kanehisa, Ren Shuang-Xi, Janet Kelso, Barrero, R.A., Eyras Jiménez, Eduardo, Kaneko Yayoi, Servant, F., Hideaki Sugawara, Tamura Takuro, Susumu Tanaka, Tonellato, Peter, Gopinath, Gopal R., Thomas Michael A, Poustka Annemarie, Sugawara, Hideaki, Sakai, Hiroaki, Nagata Naoki, Dominique Piatier-Tonneau, Gojobori Takashi, Oishi, M., Nagai Keiichi, Chisato Yamasaki, Koyanagi, K. O., Thomas, M. A., Ohtsubo, Masafumi, Shigetaka Sakamoto, Hanada Kousuke, Fukuchi, S., Andrew J Simpson, Chakraborty Ranajit, Sakate, R., Mewes Hans-Werner, Matsuda, H., Kaneko, Yayoi, Kasprzyk Arek, Hashimoto, K., Otsuki, T., Ursula Hinz, Keiichi Homma, Bellgard, M., Harada Erimi, Tanino Motohiko, Minoshima, Shinsei, R. Gopinath Gopal, Joseph D Terwilliger, Souza, Sandro J. de, Gopinath, G., Oota, Satoshi, Debily Marie-Anne, Kanapin, Alexander, Karavidopoulou, Y., De Fatima Bonaldo, M., Isogai, Takao, Per Unneberg, Okazaki Yasushi, Takeshi Itoh, Fukami-Kobayashi, Kaoru, Yoonsoo Hahn, Peter Tonellato, Hirakawa, M., Jin, L., Makino, Takashi, Thierry-Mieg, D., Brookes, A. J., Ohara Osamu, Gopinath, G.R., Takahashi Aiko, Bernhard Korn, Watanabe, S., Kazuho Ikeo, Takao Isogai, Okubo Kousaku, Unneberg, Per,, Souza, S., Yoshiyuki Sakaki, Ashurst, J., Michael Han, Kanehisa, Minoru, Gojobori, T., Barrero, R. A., de Souza, S. J., Sandrine Imbeaud, Bruford, Elspeth, Bromberg, S. K., Shimoyama, M., Makalowska, I., Simpson, A., Laurens Wilming, Devignes, M., Karavidopoulou, Youla, Han, Z-G., Otsuki Tetsuji, Hopkinson, Ian, Itoh Takeshi, Claire O'Donovan, Ogasawara, Osamu, Nakai, Kenta, Jia Libin, Okubo, Kousaku, Eveno, Eric, Shimoyama Mary, Unneberg Per, Hyang-Sook Yoo, Estreicher, Anne, Veeramachaneni, Vamsi, Servant Florence, Hans-Werner Mewes, Sakaki, Yoshiyuki, Quackenbush John, Sherry, S., Masafumi Ohtsubo, Veeramachaneni Vamsi, Kikuno, R., Wagner Lukas, Mika Hirakawa, Schupp Ingo, Vamsi Veeramachaneni, Ikeo Kazuho, Apweiler, Rolf, Kasprzyk, Arek, Sherry, Stephen, Takeda, J., Thierry-Mieg, Jean, Devignes Marie-Dominique, Eric Eveno, Nagai, K., Marie-Anne Debily, Yasuda, N., Mashima Jun, Carninci, P., Naruya Saitou, Shinya Watanabe, Mashima, J., Nakao, M., Satoru Miyazaki, Ohtsubo, M., Saitou, N., O'Donovan Claire, John Quackenbush, Kuryshev Vladimir, Miyazaki Satoru, Nishikawa, K., Nigam Rajni, Takagi, T., Han, Z., Kuryshev, V., Couillault, C., Yamaguchi-Kabata Yumi, Tamura, Takuro, Simpson, Andrew J., Watanabe, Shinya, Tanino, M., Tateno, Y., Hanaoka Hideki, Takagi, Toshihisa, Soares, B., Mulder Nicola, Mewes, H. -W, Bonaldo Maria de Fatima, Suzuki, Mami, Ikeo, Kazuho, Oishi, Michio, Mitiko Go, Lenhard, Boris, Okada Norihiro, Go, Mitiko, Homma Keiichi, Ota Motonori, Quackenbush, J., Nicola Mulder, Bromberg, S.K., Takeda Jun-ichi, Kersey, P., Rolf Apweiler, Suzuki, Y., Boris Lenhard, Vladimir Kuryshev, Hinz, U., Kanapin, A., Kei Yura, Saitou, Naruya, Chakraborty, R., Debily, Marie Anne, Ogasawara Osamu, Wagner, Lukas, Mewes, Hans-Werner, Taylor, Todd, Hanaoka, H., Gen Tamiya, Thomas, M., Miyazaki, S., Takuro Tamura, Kaneko, Y., Yasuda Tomohiro, Minoshima, S., Sakaki Yoshiyuki, Tanaka Susumu, Mano Shuhei, Yoo, H., Suwa, M., Ze-Guang Han, Tamiya Gen, Kouichi Kimura, Hashimoto Katsuyuki, Barrero, Roberto A., Sakaki, Y., Dubchak, I., Chen, Z., Debily, M., Fukuchi, Satoshi, Toshihisa Okido, Gough Craig, Fujii, Yasuyuki, Nishikawa Ken, Makiko Suwa, Nomura, Nobuo, Kersey, Paul, Auffray, Charles, Clara Amid, Sandro J de Souza, Gough, Craig, Shiba Rie, Tonellato, P., Mashima, Jun, Osamu Ohara, Wiemann, Stefan, Graudens, E., Ohara, O., Hanada, Kousuke, Endo Toshinori, Ohtsubo Masafumi, Sakate Ryuichi, Wojciech Makalowski, Homma, K., Hahn, Yoonsoo, Bruford, E., Gough, C., Go Mitiko, Yasuda, Tomohiro, Hirai, Momoki, Chen, Zhu, Nagasaki Hideki, Yasushi Okazaki, Imanishi, Tadashi, Nakao, Mitsuteru, Kimura, Kouichi, Nagasaki, Hideki, Mewes, H., Strausberg, Robert L., Hide Winston, Debily, M. -A, Stodolsky, Marvin, Kousuke Hanada, Thierry-Mieg, Danielle, Mewes, H-W, de Souza, Sandro J., Lihua Jin, Thomas, Michael A., Mary Shimoyama, Katsuyuki Hashimoto, Kim Sangsoo, Hayashizaki Yoshihide, Hilton, P., Anthony J Brookes, Mariage-Samson Regine, Jun Mashima, Ken Nishikawa, Takeda, Jun-ichi, Ashurst Jennifer, Yamasaki, C., Inoko, H., Makino, T., Arek Kasprzyk, Gojobori, Takashi, Makalowski, Wojciech, Hanada, K., Kanehisa, M., Couillault Christine, Michio Oishi, Eyras Eduardo, Marie-Dominique Devignes, Tateno, Yoshio, Tonellato Peter, Takagi Toshihisa, Marvin Stodolsky, Endo, Toshinori, Itoh, T., Bonaldo, M., Maria de Fatima Bonaldo, Han, Ze Guang, Ota, Motonori, Han Ze-Guang, Hideo Matsuda, Inoko Hidetoshi, Ogasawara, O., Kelso Janet +682 morecore +1 more sourceRecovery of a medieval Brucella melitensis genome using shotgun metagenomics [PDF]
, 2014 Shotgun metagenomics provides a powerful assumption-free approach to the recovery of pathogen genomes from contemporary and historical material. We sequenced the metagenome of a calcified nodule from the skeleton of a 14th-century middle-aged male ...Milanese, Marco, Pallen, Mark J., Gemma L. Kay, Mark J. Pallen, Bandiera, P., Giuffra, V., Kay, LG., Valentina Giuffra, Kay, Gemma L, Bramanti, Barbara, Barbara Bramanti, Raffaella Bianucci, Sergeant, Martin J, Pallen, MJ., Martin J. Sergeant, Sergeant, Martin J., Milanese, M., Bandiera, Pasquale, Giuffra, Valentina, Sergeant, MJ., Bramanti, B., Kay, Gemma L., Bianucci, Raffealla, Pasquale Bandiera, Marco Milanese, Bianucci, Raffaella +25 morecore +1 more sourceStimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi +19 morewiley +1 more sourceUSP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra +16 morewiley +1 more sourceFinding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer +10 morewiley +1 more sourceOncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan +13 morewiley +1 more sourceI’ll Show You Mine, If You Show Me Yours
The Scientific World Journal, 2001 The human genome dominated science news last week. Both Science and Nature lead this week with articles about the simultaneous publication of the human genome sequence by the private company Celera Genomics and the publicly funded Human Genome Project ...doaj +1 more sourceTumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt +10 morewiley +1 more source
