Results 91 to 100 of about 17,978,895 (293)
Open questions: How many genes do we have?
BMC Biology, 2018 Seventeen years after the initial publication of the human genome, we still haven’t found all of our genes. The answer turns out to be more complex than anyone had imagined when the Human Genome Project began.
Steven L. Salzberg
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Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Yeast: one cell, one reference sequence, many genomes?
New Genetics and Society, 2019 The genome of Saccharomyces cerevisiae – brewer’s or baker’s yeast – was the first eukaryotic genome to be sequenced in 1996. The identity of that yeast genome has been not just a product of sequencing, but also of its use after sequencing and ...
Erika Szymanski +2 more
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The Human Genome Project (HGP): Dividends and challenges: A review
International Journal of Medicine and Health Development, 2010 Background: Many disorders in man have been described as genetic or hereditary in nature and have defied absolute medical treatment and cure. Genomic studies have given profound insights into the genetic organization of many organisms including man.
F E Ejezie
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History, philosophy, and science education: reflections on genetics 20 years after the human genome project. [PDF]
Hist Philos Life Sci, 2023 Meunier R.
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
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Help in Accessing Human Genome Information
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International Human Genome Sequencing Consortium
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Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
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Draft Genome Sequence of the Serratia rubidaea CIP 103234T Reference Strain, a Human-Opportunistic Pathogen. [PDF]
, 2015 We provide here the first genome sequence of a Serratia rubidaea isolate, a human-opportunistic pathogen.
Imanci, D +4 more
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Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
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