Results 91 to 100 of about 13,494,204 (297)
Integrative annotation of 21,037 human genes validated by full-length cDNA clones [PDF]
, 2004 The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited.Terwilliger Joseph D, Nagata, Naoki, Kuryshev, Vladimir, Eveno, E., Imbeaud, S., Makalowski, W., Yoshiyuki Suzuki, Sakai, Katsunaga, Graudens Esther, de Souza, S.J., Sakamoto Shigetaka, Thomas, M.A., Ashurst, Jennifer, Kanehisa Minoru, Shinsei Minoshima, Korn, B., Mitsuteru Nakao, Robert L Strausberg, Unneberg, P., Eveno Eric, Ren, S. -X, Lenhard, B., Shiba, Rie, Hilton Phillip, Sakate, Ryuichi, Bromberg Susan K, Gopal R. Gopinath, Nakai, K., Jia, Libin, Alexander Kanapin, Momoki Hirai, Barrero, R., Strausberg Robert L, Steward Charles, Suzuki, Yutaka, Okazaki, Yasushi, Makalowski Wojciech, Okido Toshihisa, Fukami-Kobayashi Kaoru, Satoshi Oota, Motohiko Tanino, Hide, Winston, R. Gopinath, Gopal, Auffray, C., de Souza, S., Shimoyama, Mary, Dubchak Inna, Osamu Ogasawara, Erimi Harada, Quackenbush, John, Jun-ichi Takeda, Steward, C., Kikuno, Reiko, Hirai, M., Isogai, T., Piero Carninci, Matsuda, Hideo, Ryuichi Sakate, Suzuki Yutaka, Kenta Nakai, Chen Zhu, Hiroaki Sakai, Shiba, R., Okubo, K., Nomura Nobuo, Sandro J. de Souza, Taylor Todd, Toshihisa Takagi, Thierry-Mieg Jean, Fukuchi Satoshi, Nagasaki, H., Hayashizaki, Yoshihide, Bellgard Matthew, Chelala Claude, Terwilliger, J., Bruford Elspeth, Apweiler Rolf, Christine Couillault, Takeya Kasukawa, Suzuki Mami, Nobuo Nomura, Sakai Katsunaga, Korn, Bernhard, Mulder, N., Amid, Clara, Schupp, Ingo, Kasukawa Takeya, Veeramachaneni, V., Wagner, L., Yura Kei, Annemarie Poustka, Yura, Kei, Ian Hopkinson, Hashimoto, Katsuyuki, Bono, H., Endo, T., Couillault, Christine, Elspeth Bruford, Bono Hidemasa, Ota Toshio, Reiko Kikuno, O'Donovan, C., Ota, M., Jia, L., Han Michael, Okazaki, Y., Shuang-Xi Ren, Tamura, T., Sakamoto, S., Bromberg, Susan K., Ohara, Osamu, Korn Bernhard, Hyang-Yoo, S., Nagata, N., Karavidopoulou Youla, Koyanagi, K.O., Soares, Bento, Tanaka, H., Charles Steward, Yamasaki, Chisato, Saitou Naruya, Yoo, H-S, Norikazu Yasuda, Imbeaud, Sandrine, Roberto A Barrero, Nishikawa Tetsuo, Izabela Makalowska, Jin Lihua, Nigam, Rajni, Gopinath, G. R., Motonori Ota, Stephen Sherry, Hiroshi Tanaka, Yayoi Kaneko, Jean Thierry-Mieg, Okada, Norihiro, Kelso, J. ; https://orcid.org/, Fukami-Kobayashi, K., Otsuki, Tetsuji, Yura, K., Ikeo, K., Hanaoka, Hideki, Rajni Nigam, Tanino, Motohiko, Sugano Sumio, Matthew Bellgard, Kaoru Fukami-Kobayashi, Oota Satoshi, Shimizu, Nobuyoshi, Sugano, Sumio, Satoshi Fukuchi, O'Donovan, Claire, Ren, S-X, Todd Taylor, Kimura Kouichi, Bonaldo, Maria de Fatima, Poustka, Annemarie, Koyanagi, K., Shimizu, N., Kanapin Alexander, Bono, Hidemasa, Chelala, Claude, Koyanagi, Kanako O., Devignes, M. -D, Stodolsky, M., Brookes, A., Strausberg, R., Danielle Thierry-Mieg, Stefan Wiemann, Eyras, Eduardo, Brookes, Anthony J., Mami Suzuki, Lukas Wagner, Hilton, Phillip, Barrero Roberto A, Suzuki Yoshiyuki, Sugawara Hideaki, Kasukawa, T., Yoshihide Hayashizaki, Mano, Shuhei, Craig Gough, Takashi Makino, Takahashi, Aiko, Shuhei Mano, Takashi Gojobori, Suzuki, Yoshiyuki, Libin Jia, Kousaku Okubo, Han, Michael, Koyanagi Kanako O, Hidemasa Bono, Inoko, Hidetoshi, Hinz Ursula, Auffray Charles, Strausberg, R.L., Yamaguchi-Kabata, Y., Devignes, Marie Dominique, Norihiro Okada, Hideki Hanaoka, Oota, S., Fujii Yasuyuki, Han, Ze-Guang, Isogai Takao, Kasprzyk, A., Ranajit Chakraborty, Itoh, Takeshi, Terwilliger, Joseph D., Florence Servant, Mulder, Nicola, Takahashi, A., Piatier-Tonneau, Dominique, Hirakawa Mika, R. Gopinath, G., Bromberg, S., Hinz, Ursula, Suwa Makiko, Hopkinson, I., Thierry-Mieg Danielle, Chelala, C., Mewes, Hans Werner, Amid, C., Hirakawa, Mika, Servant, Florence, Hishiki, T., Nomura, N., Steward, Charles, Tamiya, G., Rie Shiba, Hahn Yoonsoo, Fujii, Y., Tateno Yoshio, Sugawara, H., Ren, Shuang Xi, Naoki Nagata, Soares Bento, Hidetoshi Inoko, Sakai, H., Schupp, I., Sakamoto, Shigetaka, Lenhard Boris, Yasuda Norikazu, Nakai Kenta, Kim, S., Kersey Paul, Watanabe Shinya, de Bonaldo, M., Hishiki, Teruyoshi, Mariage-Samson, R., Toshinori Endo, Hishiki Teruyoshi, Bellgard, Matthew, Mano, S., Nishikawa, Tetsuo, Okido, T., Wiemann, S., Anne Estreicher, Hayashizaki, Y., Miyazaki, Satoru, Susan K Bromberg, Apweiler, R., Katsunaga Sakai, Han, M., Oishi Michio, Hide, W., Kanako O Koyanagi, Tetsuo Nishikawa, Nobuyoshi Shimizu, Carninci, Piero, Makino Takashi, Dubchak, Inna, Yoo, Hyang-Sook, Ren, S., Strausberg, R. L., Estreicher, A., Yamasaki Chisato, Eyras, E., Tanaka Hiroshi, Nagai, Keiichi, Wilming, Laurens, Phillip Hilton, Ota, T., Go, M., Wilming Laurens, Winston Hide, Hopkinson Ian, Yasuda, Norikazu, Graudens, Esther, Regine Mariage-Samson, Harada, Erimi, Suwa, Makiko, Claude Chelala, Sherry Stephen, Yamaguchi-Kabata, Yumi, Eduardo Eyras, Han, Z. -G, Chakraborty, Ranajit, Teruyoshi Hishiki, Yoo, H-S., Mariage-Samson, Regine, Piatier-Tonneau Dominique, Kim, Sangsoo, Takeda, Jun Ichi, Bento Soares, Poustka, A., Zhu Chen, Makalowska, Izabela, Okada, N., Youla Karavidopoulou, Amid Clara, Suzuki, M., Sakai, K., Unneberg, Per, Wiemann Stefan, Inna Dubchak, Taylor, T., Okido, Toshihisa, Charles Auffray, Kelso, J., Hirai Momoki, Jennifer Ashurst, Yasuyuki Fujii, Nigam, R., Nishikawa, Ken, Terwilliger, J.D., Gopal R Gopinath, Tetsuji Otsuki, Nakao Mitsuteru, Brookes Anthony J, Hahn, Y., Simpson, A.J., Debily, Marie-Anne, Sangsoo Kim, Imanishi Tadashi, Homma, Keiichi, Kasukawa, Takeya, Makalowska Izabela, Takeda, J-I, Yutaka Suzuki, Jin, Lihua, Terwilliger, J. D., Aiko Takahashi, Hyang-Yoo, Sook, Sakai Hiroaki, Shimizu Nobuyoshi, Michael A Thomas, Tadashi Imanishi, Esther Graudens, Paul Kersey, Stodolsky Marvin, Toshio Ota, Ren, Shuang-Xi, Carninci Piero, Tanaka, S., Imanishi, T., Yoshio Tateno, Simpson Andrew J, de Fatima Bonaldo, Maria, Yoo Hyang-Sook, Imbeaud Sandrine, Brookes, A.J., Kikuno Reiko, Tanaka, Susumu, Tamiya, Gen, de Souza Sandro J., Sugano, S., Tomohiro Yasuda, Wilming, L., Keiichi Nagai, Devignes, Marie-Dominique, Matsuda Hideo, Takeda, J. -I, Nishikawa, T., Thierry-Mieg, J., Hideki Nagasaki, Estreicher Anne, Harada, E., Ota, Toshio, Yumi Yamaguchi-Kabata, Kelso, Janet, Minoshima Shinsei, Tanaka, Hiroshi, Kimura, K., Ingo Schupp, Sumio Sugano, Piatier-Tonneau, D., Yasuda, T., Simpson, A. J., Minoru Kanehisa, Ren Shuang-Xi, Janet Kelso, Barrero, R.A., Eyras Jiménez, Eduardo, Kaneko Yayoi, Servant, F., Hideaki Sugawara, Tamura Takuro, Susumu Tanaka, Tonellato, Peter, Gopinath, Gopal R., Thomas Michael A, Poustka Annemarie, Sugawara, Hideaki, Sakai, Hiroaki, Nagata Naoki, Dominique Piatier-Tonneau, Gojobori Takashi, Oishi, M., Nagai Keiichi, Chisato Yamasaki, Koyanagi, K. O., Thomas, M. A., Ohtsubo, Masafumi, Shigetaka Sakamoto, Hanada Kousuke, Fukuchi, S., Andrew J Simpson, Chakraborty Ranajit, Sakate, R., Mewes Hans-Werner, Matsuda, H., Kaneko, Yayoi, Kasprzyk Arek, Hashimoto, K., Otsuki, T., Ursula Hinz, Keiichi Homma, Bellgard, M., Harada Erimi, Tanino Motohiko, Minoshima, Shinsei, R. Gopinath Gopal, Joseph D Terwilliger, Souza, Sandro J. de, Gopinath, G., Oota, Satoshi, Debily Marie-Anne, Kanapin, Alexander, Karavidopoulou, Y., De Fatima Bonaldo, M., Isogai, Takao, Per Unneberg, Okazaki Yasushi, Takeshi Itoh, Fukami-Kobayashi, Kaoru, Yoonsoo Hahn, Peter Tonellato, Hirakawa, M., Jin, L., Makino, Takashi, Thierry-Mieg, D., Brookes, A. J., Ohara Osamu, Gopinath, G.R., Takahashi Aiko, Bernhard Korn, Watanabe, S., Kazuho Ikeo, Takao Isogai, Okubo Kousaku, Unneberg, Per,, Souza, S., Yoshiyuki Sakaki, Ashurst, J., Michael Han, Kanehisa, Minoru, Gojobori, T., Barrero, R. A., de Souza, S. J., Sandrine Imbeaud, Bruford, Elspeth, Bromberg, S. K., Shimoyama, M., Makalowska, I., Simpson, A., Laurens Wilming, Devignes, M., Karavidopoulou, Youla, Han, Z-G., Otsuki Tetsuji, Hopkinson, Ian, Itoh Takeshi, Claire O'Donovan, Ogasawara, Osamu, Nakai, Kenta, Jia Libin, Okubo, Kousaku, Eveno, Eric, Shimoyama Mary, Unneberg Per, Hyang-Sook Yoo, Estreicher, Anne, Veeramachaneni, Vamsi, Servant Florence, Hans-Werner Mewes, Sakaki, Yoshiyuki, Quackenbush John, Sherry, S., Masafumi Ohtsubo, Veeramachaneni Vamsi, Kikuno, R., Wagner Lukas, Mika Hirakawa, Schupp Ingo, Vamsi Veeramachaneni, Ikeo Kazuho, Apweiler, Rolf, Kasprzyk, Arek, Sherry, Stephen, Takeda, J., Thierry-Mieg, Jean, Devignes Marie-Dominique, Eric Eveno, Nagai, K., Marie-Anne Debily, Yasuda, N., Mashima Jun, Carninci, P., Naruya Saitou, Shinya Watanabe, Mashima, J., Nakao, M., Satoru Miyazaki, Ohtsubo, M., Saitou, N., O'Donovan Claire, John Quackenbush, Kuryshev Vladimir, Miyazaki Satoru, Nishikawa, K., Nigam Rajni, Takagi, T., Han, Z., Kuryshev, V., Couillault, C., Yamaguchi-Kabata Yumi, Tamura, Takuro, Simpson, Andrew J., Watanabe, Shinya, Tanino, M., Tateno, Y., Hanaoka Hideki, Takagi, Toshihisa, Soares, B., Mulder Nicola, Mewes, H. -W, Bonaldo Maria de Fatima, Suzuki, Mami, Ikeo, Kazuho, Oishi, Michio, Mitiko Go, Lenhard, Boris, Okada Norihiro, Go, Mitiko, Homma Keiichi, Ota Motonori, Quackenbush, J., Nicola Mulder, Bromberg, S.K., Takeda Jun-ichi, Kersey, P., Rolf Apweiler, Suzuki, Y., Boris Lenhard, Vladimir Kuryshev, Hinz, U., Kanapin, A., Kei Yura, Saitou, Naruya, Chakraborty, R., Debily, Marie Anne, Ogasawara Osamu, Wagner, Lukas, Mewes, Hans-Werner, Taylor, Todd, Hanaoka, H., Gen Tamiya, Thomas, M., Miyazaki, S., Takuro Tamura, Kaneko, Y., Yasuda Tomohiro, Minoshima, S., Sakaki Yoshiyuki, Tanaka Susumu, Mano Shuhei, Yoo, H., Suwa, M., Ze-Guang Han, Tamiya Gen, Kouichi Kimura, Hashimoto Katsuyuki, Barrero, Roberto A., Sakaki, Y., Dubchak, I., Chen, Z., Debily, M., Fukuchi, Satoshi, Toshihisa Okido, Gough Craig, Fujii, Yasuyuki, Nishikawa Ken, Makiko Suwa, Nomura, Nobuo, Kersey, Paul, Auffray, Charles, Clara Amid, Sandro J de Souza, Gough, Craig, Shiba Rie, Tonellato, P., Mashima, Jun, Osamu Ohara, Wiemann, Stefan, Graudens, E., Ohara, O., Hanada, Kousuke, Endo Toshinori, Ohtsubo Masafumi, Sakate Ryuichi, Wojciech Makalowski, Homma, K., Hahn, Yoonsoo, Bruford, E., Gough, C., Go Mitiko, Yasuda, Tomohiro, Hirai, Momoki, Chen, Zhu, Nagasaki Hideki, Yasushi Okazaki, Imanishi, Tadashi, Nakao, Mitsuteru, Kimura, Kouichi, Nagasaki, Hideki, Mewes, H., Strausberg, Robert L., Hide Winston, Debily, M. -A, Stodolsky, Marvin, Kousuke Hanada, Thierry-Mieg, Danielle, Mewes, H-W, de Souza, Sandro J., Lihua Jin, Thomas, Michael A., Mary Shimoyama, Katsuyuki Hashimoto, Kim Sangsoo, Hayashizaki Yoshihide, Hilton, P., Anthony J Brookes, Mariage-Samson Regine, Jun Mashima, Ken Nishikawa, Takeda, Jun-ichi, Ashurst Jennifer, Yamasaki, C., Inoko, H., Makino, T., Arek Kasprzyk, Gojobori, Takashi, Makalowski, Wojciech, Hanada, K., Kanehisa, M., Couillault Christine, Michio Oishi, Eyras Eduardo, Marie-Dominique Devignes, Tateno, Yoshio, Tonellato Peter, Takagi Toshihisa, Marvin Stodolsky, Endo, Toshinori, Itoh, T., Bonaldo, M., Maria de Fatima Bonaldo, Han, Ze Guang, Ota, Motonori, Han Ze-Guang, Hideo Matsuda, Inoko Hidetoshi, Ogasawara, O., Kelso Janet, T Imanishi, T Gojobori, S Sugano, T Itoh, Hyang Sook Yoo, Sang Soo Kim +688 morecore +1 more sourceInhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli +10 morewiley +1 more sourceZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach +11 morewiley +1 more sourceThe Capsaspora genome reveals a complex unicellular prehistory of animals [PDF]
, 2013 To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflagellate Monosiga brevicollis has been reported Chen, Zehua, Kerner, Pierre, Ruiz-Trillo, Iñaki, Vervoort, Michel, Sánchez-Pons, Núria, Russ, Carsten, Kramer, Eric, Carr, Martin, Roger, Andrew J., Suga, Hiroshi, Nusbaum, Chad, de Mendoza, Alex, Haas, Brian J., Lang, B. Franz, Manning, Gerard, Sebé-Pedrós, Arnau, Torruella, Guifré, Derelle, Romain, Brown, Matthew W., Mendoza, Alex de +19 morecore +1 more sourceEpigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun +9 morewiley +1 more sourceRobert Cook-Deegan Human Genome Archive Box Listing - Set 1
, 2014 The Robert Cook-Deegan Human Genome Archive is founded on the bibliography of The Gene Wars: Science, Politics, and the Human Genome. The archive encompasses both physical and digital materials related to The Human Genome Project (HGP) and includes ...core Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD) Sejung Lee, Junghyeok Lim, Jinhyuk Bhinwiley +1 more source
