Results 111 to 120 of about 549,507 (300)
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
, 1999 review: PLAIN TALK ABOUT THE HUMAN GENOME PROJECT: A TUSKEGEE UNIVERSITY CONFERENCE ON ITS PROMISE AND PERILS ...
Fleissner, Erwin
core
Informed Consent After the Human Genome Project
, 2001 Human genome research destabilizes established notions of the "consenting research subject," because individuals who donate DNA samples for research studies necessarily reveal sensitive information not only about themselves, but also about others ...
Happe, Kelly, Mitchell, Gordon R
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
The Human Genome Project changed everything. [PDF]
Nat Rev Genet, 2020 Gibbs RA.
europepmc +1 more source
THE HUMAN GENOME PROJECT: LEGAL ASPECTS, VOLUME IV
, 1994 Legal implications of identification by genetic testing -- Presentations -- Legal implications of identification by genetic testing / Francisco M. Lledó Yagüe -- Identification by genetic testing: legal aspects / Jacqueline Rubellin-Devichi -- The ...
core
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
A synoptic survey of the bioethics of human genome research.
, 2003 The authors discuss the wider social and ethical consequences of recent developments in bioinformatics, ''DNA fingerprinting'', genetic screening, health and insurance and the patenting of life forms.
Wheale, P.R. +3 more
core +1 more source