Results 131 to 140 of about 549,507 (300)
A Fast and Sensitive Algorithm for Aligning ESTs to the Human Genome
, 2002 Introduction The Human Genome Project is an international collaboration, designed to investigate the genetic complexity of humans. Initially, the roughly three billion nucleotides of the human genome were elucidated (Celera Genomics , International ...
Jun Ogasawara +2 more
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FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
MOLECULAR MEDICINE: A PARADIGM SHIFT IN CLINICAL SCENARIO
Pakistan Journal of Medicine and DentistrySpectacular advances have been made in molecular medicine during the last few decades including the mapping of human genome project which has revolutionized the understanding of basic molecular mechanisms involved in the etio-pathogenesis of most of the
Shumaila Usman, Talat Mirza
doaj
, 1992 Presentation -- Introduction -- General remarks -- Genetic polymorphism and the surrounding environment / James Watson -- The Human Genome Project and public opinion / Jack McConnell -- Scientific revision -- The current state and future prospects ...
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
THE HUMAN GENOME PROJECT: LEGAL ASPECTS, VOLUME III
, 1994 Human genome and insurance law -- Presentations -- Genetic information and access to health insurance / Thomas H. Murray -- Insurance and genetics: a purposive analysis / Alexander Morgan Capron -- The genetic code and insurance contracts / Aurelio ...
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Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Genetic Resources, Genome Mapping and Evolutionary Genomics of the Pig (Sus scrofa)
International Journal of Biological Sciences, 2007 The pig, a representative of the artiodactyla clade, is one of the first animals domesticated, and has become an important agriculture animal as one of the major human nutritional sources of animal based protein.
Kefei Chen, Tara Baxter, William M. Muir, Martien A. Groenen, Lawrence B. Schook
doaj
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source