Results 141 to 150 of about 549,507 (300)

A Japanese history of the Human Genome Project. [PDF]

Proc Jpn Acad Ser B Phys Biol Sci, 2019
Sakaki Y.
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

The Human Genome Project

, 1994
The Human Genome Project (HGP) is a coordinated worldwide effort to precisely map the human genome and the genomes of selected model organisms. The first explicit proposal for this project dates from 1985 although its foundations (both conceptual and
Zewert, Thomas E., Hood, Leroy E., Yager, Thomas D.   +2 more
core  

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

The Bermuda Triangle: The Pragmatics, Policies, and Principles for Data Sharing in the History of the Human Genome Project. [PDF]

J Hist Biol, 2018
Maxson Jones K, Ankeny RA, Cook-Deegan R.   +2 more
europepmc   +1 more source

National Human Genome Research Institute

The National Human Genome Research Institute (NHGRI) has many accolades to its credit, not the least being their work on sequencing the human genome. They have made substantial contributions to every sector of genomic research since their founding in ...

core  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Lessons from the Human Genome Project: Modesty, Honesty, and Realism. [PDF]

Front Genet, 2017
Emmert-Streib F, Dehmer M, Yli-Harja O.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Human Genome Project and Parasitic Infections

European Journal of Inflammation, 2004
S. Frydas, E. Karagouni, T. Iezzi, D. Kempuraj, C.M.V. Conti, W. Boucher, N. G. Papadoopoulou, J. Donelan, B. Madhappan, R. Letourneau, G. Carratelli, A. Grilli, F. Conti, G. Riccioni, D. Tripodi, F. Meneghini, L. Stellin, G. Sabatino   +17 more
doaj   +1 more source