Results 101 to 110 of about 201,232 (262)

Exuberant innovation: The Human Genome Project [PDF]

open access: yesResearch Policy 40, 1412-1425 (2011), 2010
We present a detailed synthesis of the development of the Human Genome Project (HGP) from 1986 to 2003 in order to test the "social bubble" hypothesis that strong social interactions between enthusiastic supporters of the HGP weaved a network of reinforcing feedbacks that led to a widespread endorsement and extraordinary commitment by those involved in
arxiv  

Impact of the Human Genome Project on Epidemiologic Research [PDF]

open access: bronze, 1997
Darrell L. Ellsworth   +2 more
openalex   +1 more source

Genomics and the human genome project: implications for psychiatry [PDF]

open access: yesInternational Review of Psychiatry, 2004
In the past decade the Human Genome Project has made extraordinary strides in understanding of fundamental human genetics. The complete human genetic sequence has been determined, and the chromosomal location of almost all human genes identified. Presently, a large international consortium, the HapMap Project, is working to identify a large portion of ...
openaire   +4 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Proyecto genoma humano: un arma de doble filo The Human Genome Project: A double edge weapon

open access: yesHumanidades Médicas, 2001
Después de breve reseña histórica que informa sobre los sorprendentes avances de la genética a partir del descubrimiento de la estructura helicoidal del DNA, el artículo centra su atención en el nacimiento de los estudios genómicos en los Estados Unidos ...
Elizabeth Hernández Moore   +2 more
doaj  

Agriculture driving male expansion in Neolithic Time [PDF]

open access: yesarXiv, 2013
The emergence of agriculture is suggested to have driven extensive human population growths. However, genetic evidence from maternal mitochondrial genomes suggests major population expansions began before the emergence of agriculture. Therefore, role of agriculture that played in initial population expansions still remains controversial.
arxiv  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Human Genome Book: Words, Sentences and Paragraphs [PDF]

open access: yesarXiv
Since the completion of the human genome sequencing project in 2001, significant progress has been made in areas such as gene regulation editing and protein structure prediction. However, given the vast amount of genomic data, the segments that can be fully annotated and understood remain relatively limited.
arxiv  

Understanding Transcriptional Regulation Using De-novo Sequence Motif Discovery, Network Inference and Interactome Data [PDF]

open access: yesarXiv, 2007
Gene regulation is a complex process involving the role of several genomic elements which work in concert to drive spatio-temporal expression. The experimental characterization of gene regulatory elements is a very complex and resource-intensive process.
arxiv  

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