Results 101 to 110 of about 201,232 (262)
Exuberant innovation: The Human Genome Project [PDF]
We present a detailed synthesis of the development of the Human Genome Project (HGP) from 1986 to 2003 in order to test the "social bubble" hypothesis that strong social interactions between enthusiastic supporters of the HGP weaved a network of reinforcing feedbacks that led to a widespread endorsement and extraordinary commitment by those involved in
arxiv
Impact of the Human Genome Project on Epidemiologic Research [PDF]
Darrell L. Ellsworth+2 more
openalex +1 more source
Genomics and the human genome project: implications for psychiatry [PDF]
In the past decade the Human Genome Project has made extraordinary strides in understanding of fundamental human genetics. The complete human genetic sequence has been determined, and the chromosomal location of almost all human genes identified. Presently, a large international consortium, the HapMap Project, is working to identify a large portion of ...
openaire +4 more sources
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair+17 more
wiley +1 more source
Proyecto genoma humano: un arma de doble filo The Human Genome Project: A double edge weapon
Después de breve reseña histórica que informa sobre los sorprendentes avances de la genética a partir del descubrimiento de la estructura helicoidal del DNA, el artículo centra su atención en el nacimiento de los estudios genómicos en los Estados Unidos ...
Elizabeth Hernández Moore+2 more
doaj
Agriculture driving male expansion in Neolithic Time [PDF]
The emergence of agriculture is suggested to have driven extensive human population growths. However, genetic evidence from maternal mitochondrial genomes suggests major population expansions began before the emergence of agriculture. Therefore, role of agriculture that played in initial population expansions still remains controversial.
arxiv
Project to sequence human genome moves on to the starting blocks [PDF]
openalex +1 more source
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes+20 more
wiley +1 more source
Human Genome Book: Words, Sentences and Paragraphs [PDF]
Since the completion of the human genome sequencing project in 2001, significant progress has been made in areas such as gene regulation editing and protein structure prediction. However, given the vast amount of genomic data, the segments that can be fully annotated and understood remain relatively limited.
arxiv
Understanding Transcriptional Regulation Using De-novo Sequence Motif Discovery, Network Inference and Interactome Data [PDF]
Gene regulation is a complex process involving the role of several genomic elements which work in concert to drive spatio-temporal expression. The experimental characterization of gene regulatory elements is a very complex and resource-intensive process.
arxiv