Results 151 to 160 of about 499,950 (305)

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Ethical considerations in utilizing artificial intelligence for analyzing the NHGRI's History of Genomics and Human Genome Project archives. [PDF]

J Escience Librariansh
Hosseini M, Hong S, Holmes K, Wetterstrand K, Donohue C, Amaral LAN, Stoeger T.   +6 more
europepmc   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

The genetic history and diversity of humanity - History, identity and meaning in the Human Genome Diversity Project and the Genographic Project

, 2011
T.M. Drost
openalex   +1 more source

Personal genomes in progress: from the Human Genome Project to the Personal Genome Project

, 2010
Jeantine E. Lunshof, Jason Bobe, John Aach, Misha Angrist, Joseph V. Thakuria, Daniel B. Vorhaus, Margret R. Hoehe, George M. Church   +7 more
openalex   +1 more source

National and international collaboration to facilitate human genomics data sharing in Australia: The Human Genomes Platform Project

, 2022
Tiffany Boughtwood, Joe Copty, Mark Cowley, Kylie Davies, K. A. Druken, Ben Evans, Andrew T. B. Gilbert, Christina R. Hall, Oliver Hofmann, Jessica Holliday, Warren Kaplan, Ross Koufariotis, Sarah Kummerfeld, Angela Lin, Andrew Lonie, Siobhann McCafferty, Andrew D. Patterson, John E. Pearson, Bernard J. Pope, Shyamsundar Ravishankar, Florian Reisinger, A. Robinson, John Scullen, Mustafa Syed   +23 more
openalex   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

J. Craig Venter--The Human Genome Project. [PDF]

Mayo Clin Proc, 2011
Shampo MA, Kyle RA.
europepmc   +1 more source

The <i>Human Genome Project</i> as a case study in the debate about the relationship between theology and natural science

, 2005
Johan Buitendag
openalex   +2 more sources

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source