Results 11 to 20 of about 644,208 (305)

Factors that influence a patient’s decision to engage in genetic research

Frontiers in Public Health, 2023
IntroductionThe most challenging step in clinical research studies is patient recruitment. Many research studies do not reach their targets because of participant rejection.
Amal Almutairi, Fatimah Abdulrahman Alqubaishi, Ebtehal A. Alsolm, Albandari Binowayn, Rania Almohammad, Tariq Wani, Aljohara Ababtain, Udai Alkadi, May M. Alrashed, Malak Althagafi, Leen Abu-Safieh   +10 more
doaj   +1 more source

Epigenetic effects toward new insights as potential therapeutic target in B-thalassemia

Journal of Genetic Engineering and Biotechnology, 2021
Background Fetal hemoglobin (HbF) induction has shown promise for the treatment of β-hemoglobinopathies. HbF induction in β-thalassemia could overcome ineffective hematopoiesis and thus terminate transfusion dependency for formerly transfusion dependant ...
Noha Hamdy Eltaweel, Ghada Youssef ElKamah, Rabab Khairat, Hanan Abd Elmawgoud Atia, Khalda S. Amr   +4 more
doaj   +1 more source

The Human Genome Project [PDF]

Clinical Obstetrics and Gynecology, 1993
The Human Genome Project in the United States is now well underway. Its programmatic direction was largely set by a National Research Council report issued in 1988. The broad framework supplied by this report has survived almost unchanged despite an upheaval in the technology of genome analysis. This upheaval has primarily affected physical and genetic
B. J. F. Rossiter, Charles T. Caskey
openaire   +6 more sources

Genome-wide copy number variation analysis of hepatitis B infection in a Japanese population

Human Genome Variation, 2021
Hepatitis B: Gene copy numbers associated with risk of infection The risk of contracting the hepatitis B virus may be linked to the number of copies of certain genes in an individual’s genome.
Masataka Kikuchi, Kaori Kobayashi, Nao Nishida, Hiromi Sawai, Masaya Sugiyama, Masashi Mizokami, Katsushi Tokunaga, Akihiro Nakaya   +7 more
doaj   +1 more source

Narcolepsy type I-associated DNA methylation and gene expression changes in the human leukocyte antigen region

Scientific Reports, 2023
Narcolepsy type 1 (NT1) is caused by a loss of hypothalamic orexin-producing cells, and autoreactive CD4+ and CD8+ T cells have been suggested to play a role in the autoimmune mechanism.
Kugui Yoshida-Tanaka, Mihoko Shimada, Yoshiko Honda, Akihiro Fujimoto, Katsushi Tokunaga, Makoto Honda, Taku Miyagawa   +6 more
doaj   +1 more source

rs2013278 in the multiple immunological-trait susceptibility locus CD28 regulates the production of non-functional splicing isoforms

Human Genomics, 2022
Background Ligation of CD28 with ligands such as CD80 or CD86 provides a critical second signal alongside antigen presentation by class II major histocompatibility complex expressed on antigen-presenting cells through the T cell antigen receptor for ...
Yuki Hitomi, Yoshihiro Aiba, Kazuko Ueno, Nao Nishida, Yosuke Kawai, Minae Kawashima, Makoto Tsuiji, Chisato Iwabuchi, Sanami Takada, Noriko Miyake, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura   +12 more
doaj   +1 more source

Genome-Wide Association Study for Chronic Hepatitis B Infection in the Thai Population

Frontiers in Genetics, 2022
To identify novel host genetic variants that predispose to hepatitis B virus (HBV) persistence, we performed the first genome-wide association study in the Thai population involving 318 cases of chronic hepatitis B and 309 healthy controls after quality ...
Saeideh Ashouri, Saeideh Ashouri, Seik-Soon Khor, Seik-Soon Khor, Yuki Hitomi, Hiromi Sawai, Nao Nishida, Masaya Sugiyama, Yosuke Kawai, Yosuke Kawai, Nawarat Posuwan, Nawarat Posuwan, Pisit Tangkijvanich, Piyawat Komolmit, Piyawat Komolmit, Makoto Tsuiji, Vorasuk Shotelersuk, Yong Poovorawan, Masashi Mizokami, Katsushi Tokunaga, Katsushi Tokunaga   +20 more
doaj   +1 more source

rs1944919 on chromosome 11q23.1 and its effector genes COLCA1/COLCA2 confer susceptibility to primary biliary cholangitis

Scientific Reports, 2021
Primary biliary cholangitis (PBC) is a chronic, progressive cholestatic liver disease in which intrahepatic bile ducts are destroyed by an autoimmune reaction.
Yuki Hitomi, Yoshihiro Aiba, Yosuke Kawai, Kaname Kojima, Kazuko Ueno, Nao Nishida, Minae Kawashima, Olivier Gervais, Seik-Soon Khor, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura, Makoto Tsuiji   +12 more
doaj   +1 more source

Importance of HBsAg recognition by HLA molecules as revealed by responsiveness to different hepatitis B vaccines

Scientific Reports, 2021
Hepatitis B (HB) vaccines (Heptavax-II and Bimmugen) designed based on HBV genotypes A and C are mainly used for vaccination against HB in Japan. To determine whether there are differences in the genetic background associated with vaccine responsiveness,
Nao Nishida, Masaya Sugiyama, Jun Ohashi, Yosuke Kawai, Seik-Soon Khor, Sohji Nishina, Kazumi Yamasaki, Hirohisa Yazaki, Kaori Okudera, Akihiro Tamori, Yuichiro Eguchi, Aiko Sakai, Keisuke Kakisaka, Hiromi Sawai, Takayo Tsuchiura, Miyuki Ishikawa, Keisuke Hino, Ryo Sumazaki, Yasuhiro Takikawa, Tatsuo Kanda, Osamu Yokosuka, Hiroshi Yatsuhashi, Katsushi Tokunaga, Masashi Mizokami   +23 more
doaj   +1 more source

Genetics of Charcot-Marie-Tooth (CMT) Disease within the Frame of the Human Genome Project Success. [PDF]

Genes (Basel), 2014
Timmerman V, Strickland AV, Züchner S.
europepmc   +3 more sources