Results 21 to 30 of about 908,738 (290)

The human genome as the common heritage of humanity

Frontiers in Genetics, 2023
While debate on the international regulation of human genomic research remains unsettled, the Universal Declaration on the Human Genome and Human Rights, 1997 qualifies the human genome as “heritage of humankind” in a symbolic sense.
Faith Kabata, Donrich Thaldar, Donrich Thaldar   +2 more
doaj   +1 more source

Draft Genome Sequences of 1,183 Salmonella Strains from the 100K Pathogen Genome Project. [PDF]

, 2017
Salmonella is a common food-associated bacterium that has substantial impact on worldwide human health and the global economy. This is the public release of 1,183 Salmonella draft genome sequences as part of the 100K Pathogen Genome Project.
Arabyan, Narine, Chen, Poyin, Chin, Ning, Davis, Matthew, Foutouhi, Azarene, Foutouhi, Soraya, Huang, Bihua C, Kaufman, James, Kong, Nguyet, Ng, Whitney, Storey, Dylan B, Thao, Kao, Weimer, Bart C, Weis, Allison M, Xie, Yi   +14 more
core   +1 more source

Genome‐Wide Association Study of Lean Nonalcoholic Fatty Liver Disease Suggests Human Leukocyte Antigen as a Novel Candidate Locus

Hepatology Communications, 2020
Nonalcoholic fatty liver disease (NAFLD) is supposed to manifest its metabolic phenotype in the liver, but it is common to have lean individuals diagnosed with NAFLD, known as lean NAFLD.
Ken Yoshida, Kazuha Yokota, Yukinobu Kutsuwada, Kazuhiro Nakayama, Kazuhisa Watanabe, Ayumi Matsumoto, Hiroshi Miyashita, Seik‐soon Khor, Katsushi Tokunaga, Yosuke Kawai, Masao Nagasaki, Sadahiko Iwamoto   +11 more
doaj   +1 more source

A Short History of the Genome-Wide Association Study: Where We Were and Where We Are Going [PDF]

Genomics & Informatics, 2012
Recent rapid advances in genetic research are ushering us into the genome sequence era, where an individual's genome information is utilized for clinical practice.
Shiro Ikegawa
doaj   +1 more source

Genome maps across 26 human populations reveal population-specific patterns of structural variation. [PDF]

, 2019
Large structural variants (SVs) in the human genome are difficult to detect and study by conventional sequencing technologies. With long-range genome analysis platforms, such as optical mapping, one can identify large SVs (>2 kb) across the genome in ...
Cao, Han, Chan, Ting-Fung, Chow, Eugene YC, Chu, Catherine, Chung, Claire YL, Hastie, Alex R, Jin, Nana, Kwok, Pui-Yan, Lam, Ernest T, Leung, Alden KY, Levy-Sakin, Michal, Li, Le, Lin, Chin, Ma, Walfred, McCaffrey, Jennifer, Mostovoy, Yulia, Naguib, Ahmed, Pastor, Steven, Poon, Annie, Rajagopalan, Ramakrishnan, Sibert, Justin, Wang, Wei-Ping, Wong, Karen HY, Xiao, Ming, Yip, Kevin Y, Young, Eleanor   +25 more
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ENCODE: A Sourcebook of Epigenomes and Chromatin Language [PDF]

Genomics & Informatics, 2013
Until recently, since the Human Genome Project, the general view has been that the majority of the human genome is composed of junk DNA and has little or no selective advantage to the organism.
Maryam Yavartanoo, Jung Kyoon Choi
doaj   +1 more source

Intergenerational effect of short-term spaceflight in mice

iScience, 2021
Summary: As space travel becomes more accessible, it is important to understand the effects of spaceflight including microgravity, cosmic radiation, and psychological stress. However, the effect on offspring has not been well studied in mammals.
Keisuke Yoshida, Shin-ichiro Fujita, Ayako Isotani, Takashi Kudo, Satoru Takahashi, Masahito Ikawa, Dai Shiba, Masaki Shirakawa, Masafumi Muratani, Shunsuke Ishii   +9 more
doaj   +1 more source

REAPR: a universal tool for genome assembly evaluation. [PDF]

, 2013
Methods to reliably assess the accuracy of genome sequence data are lacking. Currently completeness is only described qualitatively and mis-assemblies are overlooked.
Berriman, Matthew, Hunt, Martin, Kikuchi, Taisei, Newbold, Chris, Otto, Thomas D, Sanders, Mandy   +5 more
core   +2 more sources

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

Nature Communications, 2017
Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profiles ...
Sam Behjati, Patrick S. Tarpey, Kerstin Haase, Hongtao Ye, Matthew D. Young, Ludmil B. Alexandrov, Sarah J. Farndon, Grace Collord, David C. Wedge, Inigo Martincorena, Susanna L. Cooke, Helen Davies, William Mifsud, Mathias Lidgren, Sancha Martin, Calli Latimer, Mark Maddison, Adam P. Butler, Jon W. Teague, Nischalan Pillay, Adam Shlien, Ultan McDermott, P. Andrew Futreal, Daniel Baumhoer, Olga Zaikova, Bodil Bjerkehagen, Ola Myklebost, M. Fernanda Amary, Roberto Tirabosco, Peter Van Loo, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell   +32 more
doaj   +1 more source

Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis

Frontiers in Endocrinology, 2021
BackgroundA limited number of targeted therapy options exist for papillary thyroid cancer (PTC) to date. Based on genetic alterations reported by the “The Cancer Genome Atlas (TCGA)”, we explored whether PTC shows alterations that may be targetable by ...
Daniel A. Hescheler, Daniel A. Hescheler, Burkhard Riemann, Milan J. M. Hartmann, Maximilian Michel, Michael Faust, Christiane J. Bruns, Hakan Alakus, Costanza Chiapponi   +8 more
doaj   +1 more source