Results 301 to 310 of about 1,820,127 (391)

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

open access: yesAdvanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv   +8 more
wiley   +1 more source

Deciphering the Evolution Pattern of Structural Variations Overlapped With Repetitive Sequence During Cattle Evolution

open access: yesAdvanced Science, EarlyView.
The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo   +16 more
wiley   +1 more source

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

open access: yesAdvanced Science, EarlyView.
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman   +15 more
wiley   +1 more source

An improved reporter gene assay for evaluating the biological activity of recombinant human growth hormone. [PDF]

open access: yesJ Pharm Anal
Zhang X   +10 more
europepmc   +1 more source

Weight loss-independent changes in human growth hormone during water-only fasting: a secondary evaluation of a randomized controlled trial. [PDF]

open access: yesFront Endocrinol (Lausanne)
Horne BD   +7 more
europepmc   +1 more source

Insulin resistance reduction, intermittent fasting, and human growth hormone: secondary analysis of a randomized trial. [PDF]

open access: yesNPJ Metab Health Dis
Horne BD   +7 more
europepmc   +1 more source

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