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Coarse graining the human gut microbiome
Cell Host & Microbe, 2023The composition of the human gut microbiome is heterogeneous across people. However, if you squint, co-abundant microbial genera emerge, accounting for much of this ecological variability. In this issue of Cell Host & Microbe, Frioux et al. provide a workflow for identifying these bacterial guilds, or "enterosignatures."
Christian Diener, Sean M. Gibbons
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Human Gut Microbiome: Function Matters
Trends in Microbiology, 2018The human gut microbiome represents a complex ecosystem contributing essential functions to its host. Recent large-scale metagenomic studies have provided insights into its structure and functional potential. However, the functional repertoire which is actually contributed to human physiology remains largely unexplored. Here, by leveraging recent omics
Anna, Heintz-Buschart, Paul, Wilmes
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Culturing Human Gut Microbiomes in the Laboratory
Annual Review of Microbiology, 2021The human gut microbiota is a complex community of prokaryotic and eukaryotic microbes and viral particles that is increasingly associated with many aspects of host physiology and health. However, the classical microbiology approach of axenic culture cannot provide a complete picture of the complex interactions between microbes and their hosts in vivo.
Simone, Renwick +8 more
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Human-gut-microbiome on a chip
Nature Biomedical Engineering, 2019A microfluidic chip incorporating oxygen gradients, a diverse human microbiota and patient-derived cells, mimics interactions between microorganisms and host tissue in the human gut.
Roberta Poceviciute, Rustem F. Ismagilov
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The Human Gut Microbiome and Its Dysfunctions
Digestive Diseases, 2013The human gastrointestinal tract hosts more than 100 trillion bacteria and archaea, which together make up the gut microbiota. The amount of bacteria in the human gut outnumbers human cells by a factor of 10, but some finely tuned mechanisms allow these microorganisms to colonize and survive within the host in a mutual relationship.
Mondot, Stanislas +3 more
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The shrinking human gut microbiome
Current Opinion in Microbiology, 2017Mammals harbor complex assemblages of gut bacteria that are deeply integrated with their hosts' digestive, immune, and neuroendocrine systems. Recent work has revealed that there has been a substantial loss of gut bacterial diversity from humans since the divergence of humans and chimpanzees.
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The human gut microbiome, a taxonomic conundrum
Systematic and Applied Microbiology, 2015From culture to metagenomics, within only 130 years, our knowledge of the human microbiome has considerably improved. With >1000 microbial species identified to date, the gastro-intestinal microbiota is the most complex of human biotas. It is composed of a majority of Bacteroidetes and Firmicutes and, although exhibiting great inter-individual ...
Senthil Alias, Sankar +4 more
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The Human Gut Microbiome in Liver Diseases
Seminars in Liver Disease, 2017AbstractRecent advances in culture-independent laboratory techniques and bioinformatics have contributed to enriched characterizations of the gut microbiota and microbiome in chronic liver diseases such as alcoholic liver disease, nonalcoholic fatty liver disease, primary sclerosing cholangitis, primary biliary cholangitis, and cirrhosis.
Brian C, Davis, Jasmohan S, Bajaj
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Trust your gut: The human microbiome
InnovAiT: Education and inspiration for general practice, 2022All mucosal surfaces of the human body are home to vast, complex communities of microbial organisms. These multitudes of non-pathological microbes are otherwise known as the human ‘microbiome’. It is only in recent years with developments in genome coding, that we are beginning to comprehend the significance of the microbiome on host physiology and ...
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Evolutionary Perspectives on the Human Gut Microbiome
2018The renewed interest in human gut microbiome research spawned by modern developments in metagenomics resulted in many fascinating new results, but confusion and seeming contradictions are still common in this nascent field. As for other subdisciplines of biology, evolutionary biology serves as a unifying principle in studying host-microbe interactions.
Doms, S., Hermes, B., Baines, J.
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