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From Next-Generation Sequencing to Systematic Modeling of the Gut Microbiome
Changes in the human gut microbiome is associated with altered human metabolism and health, yet the mechanisms of interactions between microbial species and human metabolism have not been clearly elucidated.
Boyang eJi, Jens eNielsen
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Vast numbers of microorganisms inhabit the mammalian gastrointestinal tract in a complex community referred to as the gut microbiome. An individual’s microbiome may be impacted by genetics, diet, and various environmental factors, and has been associated
Maya O. Wills +7 more
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The gut microbiome is important for human health, yet modulation requires more insight into inter-individual variation. Here, we explored latent structures of the human gut microbiome across the human lifespan, applying partitioning, pseudotime, and ...
Julien Tap +8 more
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Plasticity in the Human Gut Microbiome Defies Evolutionary Constraints
The gut microbiome of primates, including humans, is reported to closely follow host evolutionary history, with gut microbiome composition being specific to the genetic background of its primate host.
Andres Gomez +26 more
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The Complex Link and Disease Between the Gut Microbiome and the Immune System in Infants
The human gut microbiome is important for human health. The development of stable microbial communities in the gastrointestinal tract is closely related to the early growth and development of host immunity. After the birth of a baby, immune cells and the
Huan Zhang +4 more
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Background Comparative data from non-human primates provide insight into the processes that shaped the evolution of the human gut microbiome and highlight microbiome traits that differentiate humans from other primates.
Katherine R. Amato +12 more
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Genomic Expansions in the Human Gut Microbiome [PDF]
Abstract Bacteria inhabiting the human body vary in genome size by over an order of magnitude, but the processes that generate this diversity are poorly understood. Here, we show that evolutionary forces drive divergence in genome size between bacterial lineages in the gut and their closest relatives in other body sites.
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Hypoxia Inducible Factor-1α: The Curator of Gut Homeostasis
The human gut microbiome is a stratified and resilient ecosystem co-inhabited by a diverse and dynamic pool of microorganisms. Microbial selection, establishment, and colonization are modulated through a complex molecular network of host-microbial ...
Tarun Kumar +2 more
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Gut Microbiome-Human Body Symbiosis
There appears to be a collaborative nexus between the human body and its resident microbes. Research is showing strong associations between this parallel universe of microorganisms and our overall health, immunity, and behavior. The human microbiome consists of microbes that flourish in different parts of the body.
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“I Am I and My Bacterial Circumstances”: Linking Gut Microbiome, Neurodevelopment, and Depression
Recently, there has been renewed interest in the role played by microbiome in both human health and human disease. A correct equilibrium between the human host and their microorganisms is important for an appropriate physiological function.
Juan M. Lima-Ojeda +2 more
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