Results 41 to 50 of about 121,767 (265)
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Modeling metabolism of the human gut microbiome
Current Opinion in Biotechnology, 2018 The human gut microbiome plays an important part in human health. The complexity of the microbiome makes it difficult to determine the detailed metabolic functions and cross-talk occurs between the individual species. In silico systems biology studies of the microbiome can help to identify metabolite exchanges among gut microbes.
Stefanía, Magnúsdóttir, Ines, Thiele
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Skin exposure to sunlight: a factor modulating the human gut microbiome composition
Gut Microbes, 2020 Background: The gut microbiome has been increasingly acknowledged as playing a pivotal role in human health. Therefore, a number of studies have focused on variables that impact its microbial structure and consequent functionality.
Liliane Costa Conteville +1 more
doaj +1 more source
The Potential Utility of Prebiotics to Modulate Alzheimer’s Disease: A Review of the Evidence
Microorganisms, 2021 The gut microbiome has recently emerged as a critical modulator of brain function, with the so-called gut-brain axis having multiple links with a variety of neurodegenerative and mental health conditions, including Alzheimer’s Disease (AD).
Jea Woo Kang, Angela M. Zivkovic
doaj +1 more source
Subspecies in the global human gut microbiome
Molecular Systems Biology, 2017 Molecular Systems Biology, 13 (12)
Paul I Costea +9 more
openaire +6 more sources
Protection of the human gut microbiome from antibiotics [PDF]
The Journal of Infectious Diseases, 2017 ABSTRACTBackgroundAntibiotics are life-saving drugs but severely affect the gut microbiome with short term consequences including diarrhoea,Clostridium difficileinfections and selection of antibiotic-resistant bacteria. Long-term links to allergy and obesity are also suggested.
Jean de Gunzburg +17 more
openaire +5 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Human gut microbiome: the second genome of human body [PDF]
Protein & Cell, 2010 The human body is actually a super-organism that is composed of 10 times more microbial cells than our body cells. Metagenomic study of the human microbiome has demonstrated that there are 3.3 million unique genes in human gut, 150 times more genes than our own genome, and the bacterial diversity analysis showed that about 1000 bacterial species are ...
Baoli, Zhu, Xin, Wang, Lanjuan, Li
openaire +2 more sources
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source