Results 111 to 120 of about 9,764,220 (350)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BK-beta-1-subunit leads to progressive hearing loss [PDF]

, 2005
The large conductance voltage- and Ca2+-activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of cochlear inner hair cells.
Arntz, Claudia, Braig, Claudia, Engel, Jutta, Hirt, Bernhard, Knipper, Marlies, Knirsch, Martina, Köpschall, Iris, Langer, Patricia, Müller, Marcus, Münkner, Stefan, Pfaff, Imke, Pfister, Markus, Rohbock, Karin, Ruth, Peter, Rüsch, Alfons, Rüttiger, Lukas, Sausbier, Matthias, Winter, Harald, Zimmermann, Ulrike   +18 more
core  

Assessment of Heavy Metals on Occupationally Exposed Workers From Hair Analysis [PDF]

, 2017
The use of human hair as a tool in assessing changes and abnormalities in human bodies has been increasing for last decades since it may reflect the health status or environmental condition of habitation or working place of individuals as well as ...
Adventini, N. (N), Damastuti, E. (E), Kurniawati, S. (S), Lestiani, D. D. (D), Santoso, M. (M), Syahfitri, W. Y. (W)   +5 more
core   +3 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Mammalian Keratin Associated Proteins (KRTAPs) Subgenomes: Disentangling Hair Diversity and Adaptation to Terrestrial and Aquatic Environments [PDF]

, 2014
Background: Adaptation of mammals to terrestrial life was facilitated by the unique vertebrate trait of body hair, which occurs in a range of morphological patterns.
Antunes, Agostinho, Johnson, Warren E., Khan, Imran, Maldonado, Emanuel, O\u27Brien, Stephen J., Vasconcelos, Vitor   +5 more
core   +2 more sources

Polygonum multiflorum extract support hair growth by elongating anagen phase and abrogating the effect of androgen in cultured human dermal papilla cells

BMC Complementary Medicine and Therapies, 2020
Dermal papilla cells (DPCs) play a key role in hair growth among the various cell types in hair follicles. Especially, DPCs determine the fate of hair follicle such as anagen to telogen transition and play a pivotal role in androgenic alopecia (AGA ...
J. Shin, Y. Choi, Jaeyoon Kim, Se Young Park, Y. Nam, So young Lee, Jeonghoon Jeon, M. Jin, Sang‐Hwha Lee   +8 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Biomonitoring Exposure to Platinum, Palladium and Rhodium in Young University Students from Leicester, England

Proceedings
We assessed the dietary exposure to platinum group elements [PGEs; platinum (Pt), palladium (Pd) and rhodium (Rh)] in young adults (18–23 yrs old) at De Montfort University (DMU, England).
Antonio Peña-Fernández, Manuel Higueras, María del Carmen Lobo-Bedmar, Edna Segura, María de los Ángeles Peña   +4 more
doaj   +1 more source

An archaeological mystery revealed by radiocarbon dating of cross-flow nanofiltrated amino acids derived from bone collagen, silk, and hair: case study of the bishops Baldwin I and Radbot II from Noyon-Tournai [PDF]

, 2014
Excavations in the cathedral of Tournai revealed two sepultures, which were identified by the excavators as those of bishops because of their special location in the cathedral. One burial was assigned to Baldwin I, who died in AD 1068, because (1) a ring
Boeckx, Pascal, Boudin, Mathieu, Van Strydonck, Mark, Vandenabeele, Peter   +3 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source