Results 91 to 100 of about 30,135,302 (286)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Nursing voice in provincial health policy [PDF]

, 2022
There is a prevailing narrative in the nursing literature that nurses are absent or invisible at macro-level policy discussions and that nurses lack influence in the macro-level policy sphere.
Richards, Robin Annette, University of Lethbridge. Faculty of Health Sciences   +1 more
core  

Carnitine is a friend in HFpEF and foe in HFrEF

iScience
Summary: Heart failure (HF) is a global concern, particularly HF with preserved ejection fraction (HFpEF), lacking effective treatments. Understanding the differences of metabolic profiles between HFpEF and HFrEF (heart failure with reduced ejection ...
Huiqing Wang, Haoran Wei, Mingming Zhao, Junfang Wu, Min Fei, Nan Lin, Rui Zhan, Qingyuan Liu, Qi Zhang, Xiaodong Yao, Yufei Wu, Wenxin Shan, Hongtu Cui, Liang Ji, Bing Pan, Lu Fang, Yujie Zhu, Xin Li, Yansong Guo, Dao Wen Wang, Lemin Zheng   +20 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Baystate Health Sciences Library Newsletter - Winter 2015/2016 [PDF]

, 2016
Health Sciences Library Newsletter - Winter 2016https://scholarlycommons.libraryinfo.bhs.org/library_newsletters/1009/thumbnail ...
Health Sciences Library, Baystate
core   +1 more source

Mental health: historical approaches from the human sciences and critical thinking

Clío
Mental health, understood as a set of meanings ranging from the absence of illness to holistic approaches encompassing emotional and social well-being, remains a subject of ongoing debate at the intersection of history, culture, and subjectivity.
María Gabriela Padrón Molina, Javid Francisco Escalona Oliveros, Adriana Cristina Vera Barbosa, Pedro Elías Severino González   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Baystate Health Sciences Library Newsletter - Summer 2017 [PDF]

, 2017
Health Sciences Library Newsletter - Summer 2017https://scholarlycommons.libraryinfo.bhs.org/library_newsletters/1017/thumbnail ...
Health Sciences Library, Baystate
core