Results 111 to 120 of about 30,135,302 (286)

Research excellence : Human Sciences at Auburn University. [PDF]

, 1989
"This is a publication of the Auburn University School of Human Sciences ... written and designed by the Department of Research Information, Alabama Agricultural Experiment Station.
Auburn University. School of Human Sciences, Alabama Agricultural Experiment Station. Dept. of Research Information   +1 more
core  

Biodiversity, health science, and the human right to a healthy environment

The Lancet Planetary Health
Planetary health agendas need a strong human rights focus. Both public health and the human right to a clean, healthy, and sustainable environment depend on biodiversity, ecosystems, and a healthy biosphere. Targeted transdisciplinary health research, action, and communication on biodiversity-health linkages can clarify and reinforce the human rights ...
Willetts, Liz, Fleming, Lora E, Morgera, Elisa   +2 more
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evaluation of Human Resource Productivity Dimensions Based on ACHIEVE Model: a study on personnel of hospitals affiliated to Iran University of Medical Sciences

پژوهش‌های سلامت‌محور, 2019
Evaluation of Human Resource Productivity Dimensions Based on ACHIEVE Model: a study on personnel of hospitals affiliated to Iran University of Medical Sciences Jafari Mehdi1, Hedayatirad Sedigheh2*, Aryankhesal Aidin3, Bordbar Najmeh4, Tavakoli Nader5
Mehdi Jafari, Sedigheh Hedayati rad, Aidin Aryankhesal, Najmeh Bordbar, Nader Tavakoli   +4 more
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Division of Toxicology and Human Health Sciences [PDF]

The Division of Toxicology and Human Health Sciences (DTHHS), part of the Agency for Toxic Substances and Disease Registry (ATSDR), plays a vital role in protecting people from toxic chemical exposures.Through our work, we:\u2022 Identify and investigate

core