Results 1 to 10 of about 9,508,990 (296)

A Protocol for the Automatic Construction of Highly Curated Genome-Scale Models of Human Metabolism [PDF]

Bioengineering, 2023
Genome-scale metabolic models (GEMs) have emerged as a tool to understand human metabolism from a holistic perspective with high relevance in the study of many diseases and in the metabolic engineering of human cell lines.
Igor Marin de Mas, Helena Herand, Jorge Carrasco, Lars K. Nielsen, Pär I. Johansson   +4 more
doaj   +2 more sources

The Large Scale Structure of Human Metabolism Reveals Resilience via Extensive Signaling Crosstalk [PDF]

Frontiers in Physiology, 2020
Metabolism is loosely defined as the set of physical and chemical interactions associated with the processes responsible for sustaining life. Two evident features arise whenever one looks at metabolism: first, metabolism is conformed as a very complex ...
Laura Gómez-Romero, Karina López-Reyes, Enrique Hernández-Lemus, Enrique Hernández-Lemus   +3 more
doaj   +2 more sources

Predicting metabolic biomarkers of human inborn errors of metabolism

Molecular Systems Biology, 2009
Early diagnosis of inborn errors of metabolism is commonly performed through biofluid metabolomics, which detects specific metabolic biomarkers whose concentration is altered due to genomic mutations.
Tomer Shlomi, Moran N Cabili, Eytan Ruppin   +2 more
doaj   +2 more sources

GSK3 inhibitor ameliorates steatosis through the modulation of mitochondrial dysfunction in hepatocytes of obese patients

iScience, 2021
Summary: Obesity is an important risk factor and a potential treatment target for hepatic steatosis. The maladaptation of hepatic mitochondrial flexibility plays a key role in the hepatic steatosis.
Yaqiong Li, Yi Lin, Xueya Han, Weihong Li, Wenmao Yan, Yuejiao Ma, Xin Lu, Xiaowu Huang, Rixing Bai, Haiyan Zhang   +9 more
doaj   +1 more source

SULFUR CONTAINING MINERAL WATER AS A DIETARY FACTOR CHALLENGING THE PHASE II DETOXIFICATION ENZYMES IN HUMAN INTESTINAL CELLS [PDF]

Journal of IMAB, 2022
Introduction: According to the scientific literature, sulfur contained in various foods and medicines is almost completely absorbed in the gastrointestinal tract.
Todorka Sokrateva, Oskan Tasinov, Stefka Stoeva, Diana Ivanova, Neshe Nazifova-Tasinova, Milka Nashar   +5 more
doaj   +1 more source

Link between glucose metabolism and epithelial-to-mesenchymal transition drives triple-negative breast cancer migratory heterogeneity

iScience, 2022
Summary: Intracellular and environmental cues result in heterogeneous cancer cell populations with different metabolic and migratory behaviors. Although glucose metabolism and epithelial-to-mesenchymal transition have previously been linked, we aim to ...
Samantha C. Schwager, Jenna A. Mosier, Reethi S. Padmanabhan, Addison White, Qinzhe Xing, Lauren A. Hapach, Paul V. Taufalele, Ismael Ortiz, Cynthia A. Reinhart-King   +8 more
doaj   +1 more source

Programmed PPAR-α downregulation induces inflammaging by suppressing fatty acid catabolism in monocytes

iScience, 2021
Summary: Inflammaging is associated with an increased risk of chronic disease. Monocytes are the principal immune cells for the production of inflammatory cytokines and contribute to inflammaging in the elderly.
Ming Wang, Yan Yan, Zhengguo Zhang, Xiaohan Yao, Xixi Duan, Ziming Jiang, Junfeng An, Peiguo Zheng, Yijie Han, Hao Wu, Zhaoqing Wang, Rainer Glauben, Zhihai Qin   +12 more
doaj   +1 more source

Intermittent fasting two days versus one day per week, matched for total energy intake and expenditure, increases weight loss in overweight/obese men and women

Nutrition Journal, 2022
Background Intermittent fasting (IF), consisting of either a one-day (IF1) or two consecutive days (IF2) per week, is commonly used for optimal body weight loss.
Paul J. Arciero, Karen M. Arciero, Michelle Poe, Alex E. Mohr, Stephen J. Ives, Autumn Arciero, Molly Boyce, Jin Zhang, Melissa Haas, Emma Valdez, Delaney Corbet, Kaitlyn Judd, Annika Smith, Olivia Furlong, Marley Wahler, Eric Gumpricht   +15 more
doaj   +1 more source

PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation

iScience, 2023
Summary: Skin plays central roles in systemic physiology, and it undergoes significant functional changes during aging. Members of the peroxisome proliferator-activated receptor-gamma coactivator (PGC-1) family (PGC-1s) are key regulators of the biology ...
Simon-Pierre Gravel, Youcef Ben Khalifa, Shawn McGuirk, Catherine St-Louis, Karl M. Laurin, Émilie Lavallée, Damien Benas, Stéphanie Desbouis, Frédéric Amaral, Damien D’Amours, Lionel Breton, Sibylle Jäger, Julie St-Pierre   +12 more
doaj   +1 more source

MiR-203 is an anti-obese microRNA by targeting apical sodium-dependent bile acid transporter

iScience, 2022
Summary: Obesity is characterized by excessive fat deposition within the body. Bile acids (BA) are important regulators for controlling the absorption of lipid.
Xin Liu, Feiran Cheng, Xue Bai, Tong Zhao, Limin Zhao, Lei Wang, Mingqi Li, Xianxian Wu, Xiaohui Chen, Pingping Tang, Mengxue Wang, Lintong Jiang, Chaoqi Yan, Fenghua Pei, Xu Gao, Ning Ma, Baofeng Yang, Yong Zhang   +17 more
doaj   +1 more source