Results 1 to 10 of about 1,389,274 (311)

An atlas of human metabolism. [PDF]

Sci Signal, 2020
An open-source, genome-scale human metabolic model and a web portal to explore the model are generated.
Robinson JL, Kocabaş P, Wang H, Cholley PE, Cook D, Nilsson A, Anton M, Ferreira R, Domenzain I, Billa V, Limeta A, Hedin A, Gustafsson J, Kerkhoven EJ, Svensson LT, Palsson BO, Mardinoglu A, Hansson L, Uhlén M, Nielsen J.   +19 more
europepmc   +11 more sources

A Protocol for the Automatic Construction of Highly Curated Genome-Scale Models of Human Metabolism [PDF]

Bioengineering, 2023
Genome-scale metabolic models (GEMs) have emerged as a tool to understand human metabolism from a holistic perspective with high relevance in the study of many diseases and in the metabolic engineering of human cell lines.
Igor Marin de Mas, Helena Herand, Jorge Carrasco, Lars K. Nielsen, Pär I. Johansson   +4 more
doaj   +2 more sources

The Large Scale Structure of Human Metabolism Reveals Resilience via Extensive Signaling Crosstalk [PDF]

Frontiers in Physiology, 2020
Metabolism is loosely defined as the set of physical and chemical interactions associated with the processes responsible for sustaining life. Two evident features arise whenever one looks at metabolism: first, metabolism is conformed as a very complex ...
Laura Gómez-Romero, Karina López-Reyes, Enrique Hernández-Lemus, Enrique Hernández-Lemus   +3 more
doaj   +2 more sources

Predicting metabolic biomarkers of human inborn errors of metabolism

Molecular Systems Biology, 2009
Early diagnosis of inborn errors of metabolism is commonly performed through biofluid metabolomics, which detects specific metabolic biomarkers whose concentration is altered due to genomic mutations.
Tomer Shlomi, Moran N Cabili, Eytan Ruppin   +2 more
doaj   +2 more sources

SULFUR CONTAINING MINERAL WATER AS A DIETARY FACTOR CHALLENGING THE PHASE II DETOXIFICATION ENZYMES IN HUMAN INTESTINAL CELLS [PDF]

Journal of IMAB, 2022
Introduction: According to the scientific literature, sulfur contained in various foods and medicines is almost completely absorbed in the gastrointestinal tract.
Todorka Sokrateva, Oskan Tasinov, Stefka Stoeva, Diana Ivanova, Neshe Nazifova-Tasinova, Milka Nashar   +5 more
doaj   +1 more source

GSK3 inhibitor ameliorates steatosis through the modulation of mitochondrial dysfunction in hepatocytes of obese patients

iScience, 2021
Summary: Obesity is an important risk factor and a potential treatment target for hepatic steatosis. The maladaptation of hepatic mitochondrial flexibility plays a key role in the hepatic steatosis.
Yaqiong Li, Yi Lin, Xueya Han, Weihong Li, Wenmao Yan, Yuejiao Ma, Xin Lu, Xiaowu Huang, Rixing Bai, Haiyan Zhang   +9 more
doaj   +1 more source

Human metabolic atlas: an online resource for human metabolism [PDF]

Database, 2015
Human tissue-specific genome-scale metabolic models (GEMs) provide comprehensive understanding of human metabolism, which is of great value to the biomedical research community. To make this kind of data easily accessible to the public, we have designed and deployed the human metabolic atlas (HMA) website (http://www.metabolicatlas.org).
Natapol Pornputtapong, Intawat Nookaew, Jens Nielsen   +2 more
openaire   +2 more sources

Intermittent fasting two days versus one day per week, matched for total energy intake and expenditure, increases weight loss in overweight/obese men and women

Nutrition Journal, 2022
Background Intermittent fasting (IF), consisting of either a one-day (IF1) or two consecutive days (IF2) per week, is commonly used for optimal body weight loss.
Paul J. Arciero, Karen M. Arciero, Michelle Poe, Alex E. Mohr, Stephen J. Ives, Autumn Arciero, Molly Boyce, Jin Zhang, Melissa Haas, Emma Valdez, Delaney Corbet, Kaitlyn Judd, Annika Smith, Olivia Furlong, Marley Wahler, Eric Gumpricht   +15 more
doaj   +1 more source

Link between glucose metabolism and epithelial-to-mesenchymal transition drives triple-negative breast cancer migratory heterogeneity

iScience, 2022
Summary: Intracellular and environmental cues result in heterogeneous cancer cell populations with different metabolic and migratory behaviors. Although glucose metabolism and epithelial-to-mesenchymal transition have previously been linked, we aim to ...
Samantha C. Schwager, Jenna A. Mosier, Reethi S. Padmanabhan, Addison White, Qinzhe Xing, Lauren A. Hapach, Paul V. Taufalele, Ismael Ortiz, Cynthia A. Reinhart-King   +8 more
doaj   +1 more source

Manganese metabolism in humans [PDF]

Frontiers in Bioscience, 2018
Manganese (Mn) is an essential nutrient for intracellular activities; it functions as a cofactor for a variety of enzymes, including arginase, glutamine synthetase (GS), pyruvate carboxylase and Mn superoxide dismutase (Mn-SOD). Through these metalloproteins, Mn plays critically important roles in development, digestion, reproduction, antioxidant ...
Chen, Pan, Bornhorst, Julia (Dr.), Aschner, Michael (Prof.)   +2 more
openaire   +2 more sources