Results 41 to 50 of about 1,287,033 (265)

Suppression of multiple myeloma by mitochondrial targeting

Scientific Reports, 2021
Treatment of multiple myeloma (MM) aims at inducing cell apoptosis by surpassing the limited capacity of MM cells to cope with oxidative stress. MM cell survival may further be suppressed by limiting cellular cholesterol. Long-chain fatty acid analogs of
Yana Aisen, Moshe E. Gatt, Rachel Hertz, Elia Smeir, Jacob Bar-Tana   +4 more
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism

Journal of Cachexia, Sarcopenia and Muscle
Background Bed‐rest (BR) of only a few days duration reduces muscle protein synthesis and induces skeletal muscle atrophy and insulin resistance, but the scale and juxtaposition of these events have not been investigated concurrently in the same ...
Natalie F. Shur, Elizabeth J. Simpson, Hannah Crossland, Despina Constantin, Sally M. Cordon, Dumitru Constantin‐Teodosiu, Francis B. Stephens, Matthew S. Brook, Philip J. Atherton, Kenneth Smith, Daniel J. Wilkinson, Olivier E. Mougin, Christopher Bradley, Ian A. Macdonald, Paul L. Greenhaff   +14 more
doaj   +1 more source

No evidence for metabolic adaptation during exercise-related energy compensation

iScience
Summary: The constrained energy model posits that the increased total daily energy expenditure (TDEE) in response to exercise is often less than the energy cost of the exercise prescribed.
E.W. Flanagan, G. Sanchez-Delgado, C.K. Martin, E. Ravussin, H. Pontzer, L.M. Redman   +5 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Exploration and comparative visualization of metabolic networks in GEMs with MMINT

iScience
Summary: Genome-scale metabolic models (GEMs) are essential tools in systems and engineering biology, enabling the simulation of genome-encoded pathways, predicting metabolic fluxes and emergent phenotypes.
Juan P. Molina Ortiz, Matthew J. Morgan, Amy M. Paten, Andrew C. Warden, Philip Kilby   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

T cell trafficking in human chronic inflammatory diseases

iScience
Summary: Circulating T cells, which migrate from the periphery to sites of tissue inflammation, play a crucial role in the development of various chronic inflammatory conditions.
Anna Giovenzana, Valentina Codazzi, Michele Pandolfo, Alessandra Petrelli   +3 more
doaj   +1 more source

Resistant Starch Combined with Whey Protein Increases Postprandial Metabolism and Lowers Glucose and Insulin Responses in Healthy Adult Men

Foods, 2021
Resistant starch (RS) and/or protein consumption favorably influence energy metabolism, substrate utilization, and weight management. The current study administered four different versions of a pancake breakfast containing waxy maize or RS with and ...
Alex E. Mohr, Olivia Minicucci, Dale Long, Vincent J. Miller, Allison Keller, Caitlin Sheridan, Gabriel O’brien, Emery Ward, Brad Schuler, Scott Connelly, Jens J. Holst, Arne Astrup, Feng He, Christopher L. Gentile, Paul J. Arciero   +14 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source