Results 41 to 50 of about 1,389,274 (311)

Association between cognitive performance and cortical glucose metabolism in patients with mild Alzheimer's disease [PDF]

, 2005
Background: Neuronal and synaptic function in Alzheimer's disease (AD) is measured in vivo by glucose metabolism using positron emission tomography (PET). Objective: We hypothesized that neuronal activation as measured by PET is a more sensitive index of
Teipel, S. J., Schwaiger, Markus, Drzezga, A., Hampel, H., Bokde, ALW, Leinsinger, G., Born, C., Thissen, J., Bartenstein, P., Dong, W., Schwaiger, M., Möller, Hans-Jürgen   +11 more
core   +1 more source

Genetics of human metabolism: an update [PDF]

Human Molecular Genetics, 2015
Genome-wide association studies with metabolomics (mGWAS) identify genetically influenced metabotypes (GIMs), their ensemble defining the heritable part of every human's metabolic individuality. Knowledge of genetic variation in metabolism has many applications of biomedical and pharmaceutical interests, including the functional understanding of ...
Gabi Kastenmüller, Johannes Raffler, Christian Gieger, Karsten Suhre   +3 more
openaire   +3 more sources

Mitochondrial Energy Metabolism in the Regulation of Thermogenic Brown Fats and Human Metabolic Diseases

, 2023
Brown fats specialize in thermogenesis by increasing the utilization of circulating blood glucose and fatty acids. Emerging evidence suggests that brown adipose tissue (BAT) prevents the incidence of obesity-associated metabolic diseases and several ...
Toshikazu Yoshikawa, Ping Dai, Yoshikawa, Toshikazu, Takeda, Yukimasa, Yukimasa Takeda, Dai, Ping, Yoshinori Harada, Harada, Yoshinori   +7 more
core   +1 more source

Androgen Metabolism in Human Skin [PDF]

The Journal of Clinical Endocrinology & Metabolism, 1971
ABSTRACT Androgen metabolism has been studied in fetal and adult skin with definitive identification of radiometabolites and the use of a computerized technique for their quantitative determination. After infusion of testosterone-4-14C to previable fetuses, from the 12th to 22nd week of gestation, there was a higher proportion of untransformed ...
CARLO FLAMIGNI, WILLIAM P. COLLINS, EVAGORAS N. KOULLAPIS, IAN CRAFT, CHRISTOPHER J. DEWHURST, IAN F. SOMMERVILLE   +5 more
openaire   +3 more sources

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Altered immunometabolic response to fasting in humans living with obesity

iScience
Summary: Fasting and ketosis are gaining interest for treating obesity-related immunometabolic dysfunction. We aimed to (1) characterize systemic and T cell immunometabolic responses to a 48-h fast in humans and (2) determine if responses differed ...
Helena Neudorf, Roderick E. Sandilands, Spencer Ursel, Hillary Shaba, Darren Barg, Takeshi Tsusaka, María Dolores Moya-Garzón, Erica Vaz, Patricia Schimweg, Emily L. Goldberg, Jonathan Z. Long, Karsten Krüger, Hashim Islam, Jonathan P. Little   +13 more
doaj   +1 more source

Suppression of multiple myeloma by mitochondrial targeting

Scientific Reports, 2021
Treatment of multiple myeloma (MM) aims at inducing cell apoptosis by surpassing the limited capacity of MM cells to cope with oxidative stress. MM cell survival may further be suppressed by limiting cellular cholesterol. Long-chain fatty acid analogs of
Yana Aisen, Moshe E. Gatt, Rachel Hertz, Elia Smeir, Jacob Bar-Tana   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source