Results 51 to 60 of about 1,287,033 (265)

Metabolism of glucose by human embryos [PDF]

International Journal of Gynecology & Obstetrics, 1987
Summary. Glucose turnover, as measured by CO2 production, lactate accumulation and carbon incorporation from [U-14C]glucose as sole energy substrate, was low on the 2nd day of culture of human embryos resulting from in-vitro fertilization but above that of unfertilized oocytes.
R G, Wales, D G, Whittingham, K, Hardy, I L, Craft   +3 more
openaire   +2 more sources

Thermodynamically enabled and reaction attuned estimation of metabolic fluxes

iScience
Summary: Mathematical models of metabolism based on mass-balance constraints are essential for analyzing cellular biochemistry, but their predictions are often compromised by thermodynamically infeasible flux cycles—unrealistic loops of biochemical ...
Nicolás Améstica-Toledo, Maximiliano Farías-Miño, Raúl Conejeros, David Tourigny, Marcelo Rivas-Astroza   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Liver glucose metabolism in humans [PDF]

Bioscience Reports, 2016
Information about normal hepatic glucose metabolism may help to understand pathogenic mechanisms underlying obesity and diabetes mellitus. In addition, liver glucose metabolism is involved in glycosylation reactions and connected with fatty acid metabolism.
Adeva-Andany, María M., Pérez-Felpete, Noemi, Fernández-Fernández, Carlos, Donapetry-García, Cristóbal, Pazos-García, Cristina   +4 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Metabolic Acceleration in Human Evolution [PDF]

Cell Metabolism, 2016
Humans stand out among other primates by an unusual combination of a very large brain and high fertility. Pontzer et al. (2016a) present new data on daily energy expenditure in great apes and show that the metabolic rate increased during human evolution.
openaire   +3 more sources

A Mathematical Model of the Human Metabolic System and Metabolic Flexibility [PDF]

Bulletin of Mathematical Biology, 2014
In healthy subjects some tissues in the human body display metabolic flexibility, by this we mean the ability for the tissue to switch its fuel source between predominantly carbohydrates in the postprandial state and predominantly fats in the fasted state.
Pearson, Taliesin, Wattis, Jonathan A.D., King, John. R., MacDonald, Ian A., Mazzatti, Dawn   +4 more
openaire   +4 more sources

Altered immunometabolic response to fasting in humans living with obesity

iScience
Summary: Fasting and ketosis are gaining interest for treating obesity-related immunometabolic dysfunction. We aimed to (1) characterize systemic and T cell immunometabolic responses to a 48-h fast in humans and (2) determine if responses differed ...
Helena Neudorf, Roderick E. Sandilands, Spencer Ursel, Hillary Shaba, Darren Barg, Takeshi Tsusaka, María Dolores Moya-Garzón, Erica Vaz, Patricia Schimweg, Emily L. Goldberg, Jonathan Z. Long, Karsten Krüger, Hashim Islam, Jonathan P. Little   +13 more
doaj   +1 more source