Results 71 to 80 of about 1,389,274 (311)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Carbon metabolism of enterobacterial human pathogens growing in epithelial colorectal adenocarcinoma (Caco-2) cells. [PDF]

, 2010
Analysis of the genome sequences of the major human bacterial pathogens has provided a large amount of information concerning their metabolic potential.
Götz Andreas, Götz, Andreas, Eylert, Eva, Eylert Eva, Werner Goebel, Goebel, Werner, Eva Eylert, Eisenreich, Wolfgang, Goetz, Andreas, Andreas Götz, Wolfgang Eisenreich, Eisenreich Wolfgang, Goebel Werner   +12 more
core   +1 more source

Physiology and Pathophysiology of Iron Metabolism

, 2023
This reprint focuses on the importance of the micronutrient iron in human physiological iron homeostasis and iron-related diseases. Daily adequate dietary iron supply ensures vital body functions and hemoglobin synthesis during erythropoiesis. During the

core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human

, 2009
Studies in mice have shown that PPARalpha is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARalpha in human liver.
Rakhshandehroo, M., Kersten, A.H., Müller, Michael, Müller Michael, Maryam Rakhshandehroo, Hooiveld Guido, Sander Kersten, Michael Müller, Guido Hooiveld, Müller, M.R., Kersten Sander, Rakhshandehroo, Maryam, Hooiveld, Guido, Hooiveld, G.J.E.J., Rakhshandehroo Maryam, Kersten, Sander   +15 more
core   +1 more source

A Model Integration Pipeline for the Improvement of Human Genome-Scale Metabolic Reconstructions

Journal of Integrative Bioinformatics, 2018
Metabolism has been a major field of study in the last years, mainly due to its importance in understanding cell physiology and certain disease phenotypes due to its deregulation.
Vieira Vítor, Ferreira Jorge, Rodrigues Rúben, Liu Filipe, Rocha Miguel   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism

Journal of Cachexia, Sarcopenia and Muscle
Background Bed‐rest (BR) of only a few days duration reduces muscle protein synthesis and induces skeletal muscle atrophy and insulin resistance, but the scale and juxtaposition of these events have not been investigated concurrently in the same ...
Natalie F. Shur, Elizabeth J. Simpson, Hannah Crossland, Despina Constantin, Sally M. Cordon, Dumitru Constantin‐Teodosiu, Francis B. Stephens, Matthew S. Brook, Philip J. Atherton, Kenneth Smith, Daniel J. Wilkinson, Olivier E. Mougin, Christopher Bradley, Ian A. Macdonald, Paul L. Greenhaff   +14 more
doaj   +1 more source

No evidence for metabolic adaptation during exercise-related energy compensation

iScience
Summary: The constrained energy model posits that the increased total daily energy expenditure (TDEE) in response to exercise is often less than the energy cost of the exercise prescribed.
E.W. Flanagan, G. Sanchez-Delgado, C.K. Martin, E. Ravussin, H. Pontzer, L.M. Redman   +5 more
doaj   +1 more source

The Metabolism of Human Spermatozoa.

Experimental Biology and Medicine, 1939
SummaryThe metabolism of human spermatozoa in Ringer-glucose is almost exclusively glycolytic and not respiratory. Aerobic lactic acid production is 80% of the anaerobic and falls off with time whereas anaerobic glycolysis is linear over a period of many hours.
openaire   +1 more source