Results 71 to 80 of about 1,287,033 (265)

Metformin in gastrointestinal cancers and inflammatory bowel disease: Unraveling its mechanisms and therapeutic applications

iScience
Summary: Gastrointestinal diseases have become a global health concern with high incidence and prevalence. Considering that a great many patients with gastrointestinal cancers still suffer from tumor recurrence or distant metastasis even after surgical ...
Yanxi Li, Xingqi Guo, Xinxin Dong, Tong Xia, Siping Ma, Zhexian Liu   +5 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

GLP-1 receptor agonists and acute diabetes complications in adults with type 1 diabetes

iScience
Summary: GLP-1 receptor agonists (GLP-1 RAs) are increasingly used for weight management in patients with obesity, yet their safety in those with comorbid type 1 diabetes (T1D) remains uncertain due to concerns about diabetic ketoacidosis (DKA).
Hao Dai, Yao An Lee, Rotana M. Radwan, Amy J. Sheer, Tamara S. Hannon, Matthew R. Hayes, Ramon C. Sun, Jiang Bian, Jingchuan Guo   +8 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Metabolic and endocrine effects of metabolic acidosis in humans

Swiss Medical Weekly, 2001
Metabolic acidosis is an important acid-base disturbance in humans. It is characterised by a primary decrease in body bicarbonate stores and is known to induce multiple endocrine and metabolic alterations. Metabolic acidosis induces nitrogen wasting and, in humans, depresses protein metabolism.
M, Wiederkehr, R, Krapf
openaire   +3 more sources

Suppression of adipose lipolysis by long-chain fatty acid analogs

Journal of Lipid Research, 2012
Agonist-induced lipolysis of adipose fat is robustly inhibited by insulin or by feedback inhibition by the long-chain fatty acids (LCFA) produced during lipolysis. However, the mode of action of LCFA in suppressing adipose lipolysis is not clear.
Bella Kalderon, Narmen Azazmeh, Nili Azulay, Noam Vissler, Michael Valitsky, Jacob Bar-Tana   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Canagliflozin attenuates post-resuscitation myocardial dysfunction in diabetic rats by inhibiting autophagy through the PI3K/Akt/mTOR pathway

iScience
Summary: This study investigated the effects of canagliflozin on myocardial dysfunction after cardiac arrest and cardiopulmonary resuscitation in diabetic rats and the underlying mechanisms.
Qihui Huang, Wei Shi, Minjie Wang, Liangliang Zhang, Yijun Zhang, Yan Hu, Sinong Pan, Bingrui Ling, Huaqing Zhu, Wenyan Xiao, Tianfeng Hua, Min Yang   +11 more
doaj   +1 more source

Screening for lipoprotein[a] elevations in plasma and assessment of size heterogeneity using gradient gel electrophoresis.

Journal of Lipid Research, 1989
Plasma was screened for the presence of lipoprotein[a] using 2-16% nondenaturing, polyacrylamide gradient gel electrophoresis. Gels were scanned with a densitometer after staining with Sudan black B.
J R McNamara, H Campos, J L Adolphson, J M Ordovas, P W Wilson, J J Albers, D C Usher, E J Schaefer   +7 more
doaj   +1 more source