Results 81 to 90 of about 1,389,274 (311)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Exploration and comparative visualization of metabolic networks in GEMs with MMINT
iScienceSummary: Genome-scale metabolic models (GEMs) are essential tools in systems and engineering biology, enabling the simulation of genome-encoded pathways, predicting metabolic fluxes and emergent phenotypes.
Juan P. Molina Ortiz +4 more
doaj +1 more source
Journal of Lipid Research, 2005 Microsomal triglyceride transfer protein (MTP) catalyzes the assembly of triglyceride (TG)-rich apolipoprotein B-containing liver (e.g., VLDL) and intestinal (e.g., chylomicron) lipoproteins.
Vered Sheena +5 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
T cell trafficking in human chronic inflammatory diseases
iScienceSummary: Circulating T cells, which migrate from the periphery to sites of tissue inflammation, play a crucial role in the development of various chronic inflammatory conditions.
Anna Giovenzana +3 more
doaj +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Thermodynamically enabled and reaction attuned estimation of metabolic fluxes
iScienceSummary: Mathematical models of metabolism based on mass-balance constraints are essential for analyzing cellular biochemistry, but their predictions are often compromised by thermodynamically infeasible flux cycles—unrealistic loops of biochemical ...
Nicolás Améstica-Toledo +4 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Different trajectories of exosomatic energy metabolism for Brazil, Chile and Venezuela: using the MSIASM approach [PDF]
Economic development goes hand in hand with an increase in the consumption of natural resources. Some analysts use material flows to describe such relationship [Eurostat 2001, Weisz et al., 2006], or exergy [Ayres et al., 2003].
Nina Eisenmenger +2 more
core
Metabolic and endocrine effects of metabolic acidosis in humans
Swiss Medical Weekly, 2001 Metabolic acidosis is an important acid-base disturbance in humans. It is characterised by a primary decrease in body bicarbonate stores and is known to induce multiple endocrine and metabolic alterations. Metabolic acidosis induces nitrogen wasting and, in humans, depresses protein metabolism.
M, Wiederkehr, R, Krapf
openaire +3 more sources