Results 81 to 90 of about 1,287,033 (265)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Serum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes risk

iScience
Summary: In-utero and dietary factors make important contributions toward health and development in early childhood. In this respect, serum proteomics of maturing infants can provide insights into studies of childhood diseases, which together with ...
Santosh D. Bhosale, Robert Moulder, Tomi Suomi, Terhi Ruohtula, Jarno Honkanen, Suvi M. Virtanen, Jorma Ilonen, Laura L. Elo, Mikael Knip, Riitta Lahesmaa   +9 more
doaj   +1 more source

Effect of apolipoprotein E phenotype on diet-induced lowering of plasma low density lipoprotein cholesterol.

Journal of Lipid Research, 1994
The National Cholesterol Education Program (NCEP) has recommended that dietary total fat, saturated fat, and cholesterol intake be reduced to < or = 30% of calories, < 10% of calories, and < 300 mg/day, respectively (Step 1 diet) in the general ...
J Lopez-Miranda, J.M. Ordovas, P Mata, A.H Lichtenstein, B Clevidence, J.T Judd, E.J Schaefer   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort

iScience
Summary: Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect.
Vanessa Schoissengeier, Lina Maqboul, Daniela Weber, Tilman Grune, Alexander Bürkle, Maria Moreno-Villaneuva, Claudio Franceschi, Miriam Capri, Jürgen Bernhard, Olivier Toussaint, Florence Debacq-Chainiaux, Birgit Weinberger, Efstathios S. Gonos, Ewa Sikora, Martijn Dollé, Eugène Jansen, P. Eline Slagboom, Antti Hervonnen, Mikko Hurme, Nicolle Breusing, Jan Frank, Andrew C. Bulmer, Karl-Heinz Wagner   +22 more
doaj   +1 more source

Different Types of Resistant Starch Elicit Different Glucose Reponses in Humans

Journal of Nutrition and Metabolism, 2010
The purpose of this study was to determine whether different types of resistant starch (RS) elicited different glycemic responses. Eleven healthy subjects consumed solutions containing 30 g of either dextrose (DEX), resistant starch type 2 (RS2), or ...
Mark D. Haub, Kelcie L. Hubach, Enas K. Al-tamimi, Sammy Ornelas, Paul A. Seib   +4 more
doaj   +1 more source

Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry

Journal of Lipid Research, 2002
The profile of liver acyl-CoAs induced by dietary fats of variable compositions or by xenobiotic hypolipidemic amphipathic carboxylates was evaluated in vivo using a novel electrospray ionization tandem mass spectrometry methodology of high resolution ...
B. Kalderon, V. Sheena, S. Shachrur, R. Hertz, J. Bar-Tana   +4 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Measurement of human apolipoprotein B-48 and B-100 kinetics in triglyceride-rich lipoproteins using [5,5,5-2H3]leucine.

Journal of Lipid Research, 1992
A primed-constant infusion of deuterated leucine was used in humans to determine the maximal level of enrichment at plateau of apolipoprotein (apo)B-48 and apoB-100 which are synthesized in the intestine and liver, respectively, and to compare the ...
AH Lichtenstein, DL Hachey, JS Millar, JL Jenner, L Booth, J Ordovas, EJ Schaefer   +6 more
doaj   +1 more source