Results 31 to 40 of about 1,389,274 (311)

Integrating Omics Data in Genome-Scale Metabolic Modeling: A Methodological Perspective for Precision Medicine

Metabolites, 2023
Recent advancements in omics technologies have generated a wealth of biological data. Integrating these data within mathematical models is essential to fully leverage their potential.
Partho Sen, Matej Orešič
doaj   +1 more source

Gene identification for the cblD defect of vitamin B12 metabolism [PDF]

, 2008
Background Vitamin B12 (cobalamin) is an essential cofactor in several metabolic pathways. Intracellular conversion of cobalamin to its two coenzymes, adenosylcobalamin in mitochondria and methylcobalamin in the cytoplasm, is necessary for the ...
Rosenblatt, David S., Lerner-Ellis, Jordan P, Stucki, Martin, Suormala, T, Baumgartner, Matthias R; https://orcid.org/, Baumgartner, Matthias R., Fowler, Brian, Lerner-Ellis, Jordan P., Newbold, R F, Newbold, Robert F, Coelho, D, Fowler, B, Lerner-Ellis, J P, Newbold, Robert F., Rosenblatt, D S, Coelho, David, Suormala, Terttu, Rosenblatt, David S, Stucki, M, Baumgartner, M R   +19 more
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The human batokine EPDR1 regulates β-cell metabolism and function [Elektronisk resurs]

, 2022
Objective: Ependymin-Related Protein 1 (EPDR1) was recently identified as a secreted human batokine regulating mitochondrial respiration linked to thermogenesis in brown fat.
Mulder, Hindrik,, Hodek, Ondrej,, Prasad, Rashmi B.,, Cowan, Elaine,, Moritz, Thomas,, Argemi-Muntadas, Lidia,, Hladkou, Sergey,, Gheibi, Sevda,, Scheele, Camilla,, Eliasson, Lena,, Gao, Qian,, Fex, Malin,, Lund University., Spégel, Peter,, Cataldo, Luis Rodrigo,   +14 more
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THE METABOLISM OF HUMAN ERYTHROBLASTS [PDF]

Journal of Clinical Investigation, 1936
The metabolism of human nucleated red blood cells has not previously been determined because of difficulties in procuring material. In most anemias the number of nucleated erythrocytes in the blood is so small in relation to the number of non-nucleated erythrocytes that the metabolism of the former is obscured by that of the latter.
openaire   +2 more sources

Peroxisome Metabolism in Cancer

, 2020
Peroxisomes are metabolic organelles involved in lipid metabolism and cellular redoxbalance. Peroxisomal function is central to fatty acid oxidation, ether phospholipid synthesis, bile acidsynthesis, and reactive oxygen species homeostasis.
Jung Ae Kim, Jung-Ae Kim
core   +1 more source

Morning Exercise Reduces Abdominal Fat and Blood Pressure in Women; Evening Exercise Increases Muscular Performance in Women and Lowers Blood Pressure in Men

Frontiers in Physiology, 2022
The ideal exercise time of day (ETOD) remains elusive regarding simultaneous effects on health and performance outcomes, especially in women.Purpose: Given known sex differences in response to exercise training, this study quantified health and ...
Paul J. Arciero, Stephen J. Ives, Alex E. Mohr, Nathaniel Robinson, Daniela Escudero, Jake Robinson, Kayla Rose, Olivia Minicucci, Gabriel O’Brien, Kathryn Curran, Vincent J. Miller, Feng He, Feng He, Chelsea Norton, Maia Paul, Caitlin Sheridan, Sheriden Beard, Jessica Centore, Monique Dudar, Katy Ehnstrom, Dakembay Hoyte, Heather Mak, Aaliyah Yarde   +22 more
doaj   +1 more source

Model selection reveals selective regulation of blood amino acid and lipid metabolism by insulin in humans

iScience
Summary: Insulin plays a crucial role in regulating the metabolism of blood glucose, amino acids (aa), and lipids in humans. However, the mechanisms by which insulin selectively regulates these metabolites are not fully understood.
Suguru Fujita, Ken-ichi Hironaka, Yasuaki Karasawa, Shinya Kuroda   +3 more
doaj   +1 more source

On the Metabolism of Exogenous Ketones in Humans [PDF]

Frontiers in Physiology, 2017
Background and aims: Currently there is considerable interest in ketone metabolism owing to recently reported benefits of ketosis for human health. Traditionally, ketosis has been achieved by following a high-fat, low-carbohydrate "ketogenic" diet, but adherence to such diets can be difficult. An alternative way to increase blood D-β-hydroxybutyrate (D-
Brianna J. Stubbs, Pete J. Cox, Rhys D. Evans, Peter Santer, Jack J. Miller, Jack J. Miller, Olivia K. Faull, Snapper Magor-Elliott, Satoshi Hiyama, Matthew Stirling, Kieran Clarke   +10 more
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Analysis of Human Natural Killer Cell Metabolism

, 2020
Natural Killer (NK) cells mediate mainly innate anti-tumor and anti-viral immune responses and respond to a variety of cytokines and other stimuli to promote survival, cellular proliferation, production of cytokines such as interferon gamma (IFNγ) and/or
Traba, Javier, Antón Hurtado, Olga María, Waldmann, Thomas   +2 more
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Teicoplanin metabolism in humans

Antimicrobial Agents and Chemotherapy, 1992
Teicoplanin, a lipoglycopeptide antibiotic, consists of five major components (A2-1 through A2-5), one hydrolysis component (A3-1), and four minor components (RS-1 through RS-4). All the major components contain an N-acyl-beta-D-glucosamine, but they differ in the lengths and branchings of their acyl-aliphatic chains. Previous studies with radiolabeled
A, Bernareggi, A, Borghi, M, Borgonovi, L, Cavenaghi, P, Ferrari, K, Vékey, M, Zanol, L F, Zerilli   +7 more
openaire   +3 more sources