Results 11 to 20 of about 1,389,274 (311)

Human Metabolism of Sirolimus Revisited. [PDF]

Metabolites
Background: Sirolimus (SRL, rapamycin) is a clinically important mTOR inhibitor used in immunosuppression, oncology, and cardiovascular drug-eluting devices.
Davari B, Shokati T, Ward AM, Nguyen V, Klawitter J, Klawitter J, Christians U.   +6 more
europepmc   +2 more sources

Human HDL subclasses modulate energy metabolism in skeletal muscle cells [PDF]

, 2023
In addition to its antiatherogenic role, HDL reportedly modulates energy metabolism at the whole-body level. HDL functionality is associated with its structure and composition, and functional activities can differ between HDL subclasses.
Eija Pirinen, Rustan, Arild C., Thoresen, G. Hege, Lund, Jenny, Thoresen, G Hege, Hege G. Bakke, Lähteenmäki, Emilia, Lehti, Maarit, Jenny Lund, Bakke, Hege G, Eklund, Tiia, Arild C. Rustan, Tiia Eklund, Bakke, Hege G., Jauhiainen, Matti, Emilia Lähteenmäki, Matti Jauhiainen, Rustan, Arild C, G. Hege Thoresen, Pirinen, Eija, Maarit Lehti   +20 more
core   +1 more source

Programmed PPAR-α downregulation induces inflammaging by suppressing fatty acid catabolism in monocytes

iScience, 2021
Summary: Inflammaging is associated with an increased risk of chronic disease. Monocytes are the principal immune cells for the production of inflammatory cytokines and contribute to inflammaging in the elderly.
Ming Wang, Yan Yan, Zhengguo Zhang, Xiaohan Yao, Xixi Duan, Ziming Jiang, Junfeng An, Peiguo Zheng, Yijie Han, Hao Wu, Zhaoqing Wang, Rainer Glauben, Zhihai Qin   +12 more
doaj   +1 more source

Identification of Trenbolone Metabolites Using Hydrogen Isotope Ratio Mass Spectrometry and Liquid Chromatography/High Accuracy/High Resolution Mass Spectrometry for Doping Control Analysis

Frontiers in Chemistry, 2020
Trenbolone is a synthetic anabolic-androgenic steroid, which has been misused for performance enhancement in sports. The detection of trenbolone doping in routine sports drug testing programs is complex as methods utilizing gas chromatography/mass ...
Marlen Putz, Thomas Piper, Mario Thevis
doaj   +1 more source

Glycogen metabolism in humans

BBA Clinical, 2016
In the human body, glycogen is a branched polymer of glucose stored mainly in the liver and the skeletal muscle that supplies glucose to the blood stream during fasting periods and to the muscle cells during muscle contraction. Glycogen has been identified in other tissues such as brain, heart, kidney, adipose tissue, and erythrocytes, but glycogen ...
Adeva-Andany, María M., González-Lucán, Manuel, Donapetry-García, Cristóbal, Fernández-Fernández, Carlos, Ameneiros-Rodríguez, Eva   +4 more
openaire   +2 more sources

Maternal nutritional status, C1 metabolism and offspring DNA methylation: a review of current evidence in human subjects. [PDF]

, 2011
: Evidence is growing for the long-term effects of environmental factors during early-life on later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene function not mediated by DNA sequence alteration), particularly DNA ...
Dominguez Salas, Paula, Dominguez-Salas, P, Prentice, AM, Sophie E. Moore, Cox, SE, Dominguez-Salas, Paula, Prentice, Andrew M, Hennig, Branwen J, Paula Dominguez-Salas, Andrew M. Prentice, Moore, SE, Moore, Sophie E, Hennig, BJ, Cox, Sharon E, Prentice, Andrew M., Moore, Sophie E., Hennig, Branwen J., Branwen J. Hennig, Sharon E. Cox, Cox, Sharon E.   +19 more
core   +1 more source

Morphine Metabolism in Human Skin Microsomes [PDF]

, 2012
For patients with severe skin wounds, topically applied morphine is an option to induce efficient analgesia due to the presence of opioid receptors in the skin.
Heilmann, S., Küchler, S., Schäfer-Korting, Monika, Küchler, Sarah, Schäfer-Korting, M.   +4 more
core   +1 more source

Metabolic Imaging in Humans [PDF]

Topics in Magnetic Resonance Imaging, 2016
Metabolic imaging enhances understanding of disease metabolisms and holds great potential as a measurement tool for evaluating disease prognosis and treatment effectiveness. Advancement of techniques, such as magnetic resonance spectroscopy, positron emission tomography, and mass spectrometry, allows for improved accuracy for quantification of ...
Taylor L, Fuss, Leo L, Cheng
openaire   +2 more sources

Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila [PDF]

, 2021
There has been rapid growth in the use of Drosophila and other invertebrate systems to dissect mechanisms governing metabolism. New assays and approaches to physiology have aligned with superlative genetic tools in fruit flies to provide a powerful ...
Tsao, Deborah D, Miguel-Aliaga, Irene, Kim, Seung K., Suh, Greg S.B., Suh, Greg SB, Kim, Seung K, Tsao, Deborah D.   +6 more
core   +1 more source

PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation

iScience, 2023
Summary: Skin plays central roles in systemic physiology, and it undergoes significant functional changes during aging. Members of the peroxisome proliferator-activated receptor-gamma coactivator (PGC-1) family (PGC-1s) are key regulators of the biology ...
Simon-Pierre Gravel, Youcef Ben Khalifa, Shawn McGuirk, Catherine St-Louis, Karl M. Laurin, Émilie Lavallée, Damien Benas, Stéphanie Desbouis, Frédéric Amaral, Damien D’Amours, Lionel Breton, Sibylle Jäger, Julie St-Pierre   +12 more
doaj   +1 more source