Results 221 to 230 of about 6,269,925 (357)

Academic and human resource research in health sciences

, 2012
Considering that scientific evidence in our country is a topic to be addressed by state entities and private institutions; and taking into account that this area has been incorporated in the study programs in undergraduate courses in research methodology, and also having been reinforced in postgraduate courses in universities, we have a gap and a ...
openaire   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

The Importance of Pediatric Nonhuman Primate Models in Translational HIV Research. [PDF]

J Med Primatol
Chahroudi A.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Dogs and humans share biomarkers of mortality. [PDF]

J Gerontol A Biol Sci Med Sci
Harrison BR, Akey JM, Snyder-Mackler N, Raftery D, Creevy KE, Promislow DEL, DAP Consortium.   +6 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Developmental coordination disorder traits persistently affect physical activity and sedentary behavior in adults. [PDF]

Sci Rep
Cavalcante-Neto JL, Silva JMC, Thomas G, da Silva SM, da Silva IP, Cairney J.   +5 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Human brucellosis in pregnancy in western Uganda: High seroprevalence and health risk factors identified in a cross-sectional study. [PDF]

PLoS Negl Trop Dis
Virginia W, Ishimwe MPS, Kazigo AK, Tshilumba T, Rukamba JD, Pius T, Isse SAS, Hakizimana T.   +7 more
europepmc   +1 more source

Plastics, the environment and human health: current consensus and future trends

Philosophical Transactions of the Royal Society B: Biological Sciences, 2009
Richard C. Thompson, C. Moore, F. V. vom Saal, S. Swan   +3 more
semanticscholar   +1 more source