Results 131 to 140 of about 172,650 (280)

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

Cell Proliferation, EarlyView.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far, Marziyeh Akbari, Mohammad Amin Habibi, Morteza Katavand, Sherko Nasseri   +4 more
wiley   +1 more source

Human Herpesvirus 8 Genotype E in Patients with Kaposi Sarcoma, Peru

Emerging Infectious Diseases, 2010
To determine human herpesvirus 8 (HHV-8) K1 genotypes in patients with Kaposi sarcoma (KS) from Peru, we characterized HHV-8 in 25 KS biopsy samples.
Olivier Cassar, Marie-Lise Blondot, Salim Mohanna, Gregory Jouvion, Francisco Bravo, Vicente Maco, Renan Duprez, Michel Huerre, Eduardo Gotuzzo, Antoine Gessain   +9 more
doaj   +1 more source

Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR [PDF]

, 2003
Carlos Bais, Albert Van Geelen, Pîlar Eroles, Agata D'Agostino Mutlu, Chiara Chiozzini, Sérgio Dias, Roy L. Silverstein, Shahin Rafii, Enrique A. Mesri   +8 more
openalex   +1 more source

Parvovirus B19‐associated myocarditis in children: A systematic review of clinical features, management and outcomes

European Journal of Clinical Investigation, EarlyView.
This systematic review summarizes clinical features, diagnostic strategies and outcomes of paediatric myocarditis associated with Parvovirus B19. Affected children are typically under 3 years old and often present with fulminant symptoms, severe cardiac dysfunction and a high need for ICU‐level support or mechanical circulatory assistance.
Giacomo Veronese, Giada Colombo, Andrea Garascia, Rachele Adorisio, Ezio Bonanomi, Enrico Ammirati   +5 more
wiley   +1 more source

Features of Diagnostics and Complex Approach to Therapy of Herpetic Keratitis

Oftalʹmologiâ, 2019
Objective. To determine the characteristics of drug therapy in patients with herpetic keratitis (HK), based on laboratory diagnosis.Material and methods. 49 patients with clinical symptoms of HK were included in the study.
E. A. Kleshcheva, S. A. Kochergin, Yu. B. Slonimskiy   +2 more
doaj   +1 more source

Pathogenic, Molecular, and Immunological Properties of a Virus Associated with Sea Turtle Fibropapillomatosis. Phase II : Viral Pathogenesis and Development of Diagnostic Assays [PDF]

, 2000
Research conducted under this RWO from July 1, 1997 through June 30, 2000 has provided important new information about the pathogenesis, virology, and immunology of marine turtle fibropapillomatosis. In particular, we have provided strong evidence for
Bjorndal, Karen A., Bolten, Alan, Brown, Daniel R., Coberley, Sadie, Ehrhart, Llewellyn, Herbst, Lawrence H., Klein, Paul A., Lackovich, Joel K., Moretti, Ritchie H.   +8 more
core  

Acute neurologic presentation of a 2‐year‐old standardbred colt with multicentric diffuse large B cell lymphoma

Equine Veterinary Education, EarlyView.
Summary Lymphoma in horses is uncommon and rarely diagnosed as a cause of ataxia. This case report describes a 2‐year‐old Standardbred cryptorchid colt who presented with acute onset of grade 3–4/5 spinal ataxia in all four limbs, with the hindlimbs more severely affected than forelimbs and severe proprioceptive deficits.
K. MacMillan, J. Burns, E. John, M. Buote   +3 more
wiley   +1 more source

Features of the course of viral hepatitis A in a child with persistent mixed herpesvirus infection

Лечащий Врач
Background. Today in the structure of viral hepatitis viral hepatitis A takes the lead position, the course of typical forms is usually favorable. Over the last few years, however, the frequency of viral hepatitis A has become higher, with increased ...
E. G. Khramtsova, M. D. Subbotina
doaj   +1 more source

Additional file 2: of Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6

, 2018
Figure S1. Resequencing of select iciHHV-6B specimens confirms identical sequences among unrelated patients. Samples from select iciHHV-6B specimens with identical sequences were re-extracted, re-prepared and re-sequenced from original patient material to rule out contamination or a sample specimen switch during the sequencing process.
Greninger, Alexander, Knudsen, Giselle, Pavitra Roychoudhury, Hanson, Derek, Sedlak, Ruth, Xie, Hong, Guan, Jon, Nguyen, Thuy, Peddu, Vikas, Boeckh, Michael, Meei-Li Huang, Cook, Linda, Depledge, Daniel, Zerr, Danielle, Koelle, David, Soren Gantt, Yoshikawa, Tetsushi, Caserta, Mary, Hill, Joshua, Jerome, Keith   +19 more
openaire   +1 more source

A guide to heat shock factors as multifunctional transcriptional regulators

The FEBS Journal, EarlyView.
The heat shock factors (HSFs) are evolutionarily conserved transcription factors best known as regulators of molecular chaperone genes in response to heat shock and other protein‐damaging stresses. Vertebrate HSFs, HSF1‐5, HSFX, and HSFY, are implicated in various physiological and pathological processes, including organismal development and cancer ...
Hendrik S. E. Hästbacka, Alejandro J. Da Silva, Lea Sistonen, Eva Henriksson   +3 more
wiley   +1 more source