Results 101 to 110 of about 601,020 (224)

Non-canonical regulation of the reactivation of an oncogenic herpesvirus by the OTUD4-USP7 deubiquitinases.

PLoS Pathogens
Deubiquitinases (DUBs) remove ubiquitin from substrates and play crucial roles in diverse biological processes. However, our understanding of deubiquitination in viral replication remains limited. Employing an oncogenic human herpesvirus Kaposi's sarcoma-
Shaowei Wang, Xuezhang Tian, Yaru Zhou, Jun Xie, Ming Gao, Yunhong Zhong, Chuchu Zhang, Keying Yu, Lei Bai, Qingsong Qin, Bo Zhong, Dandan Lin, Pinghui Feng, Ke Lan, Junjie Zhang   +14 more
doaj   +1 more source

Non‐Epidemic Kaposi Sarcoma Refractory to Laser Therapy in an HIV‐Negative Man Who Has Sex With Men (MSM)

JEADV Clinical Practice, Volume 5, Issue 1, Page 226-230, March 2026.
Capsule summary We report a case of non‐epidemic Kaposi sarcoma in an immunocompetent HIV‐negative man who has sex with men, presenting with localized cutaneous lesions on the foot. Multiple laser modalities—including CO2, PDL, KTP, and combined PDL/Nd:YAG—failed to achieve meaningful clinical improvement, and disease progression continued with new ...
M. Sin‐Soler, M. Martins Lopes, I. Martín Loureiro, C. Giménez Grau, F. Sacristán Lista, J. del Pozo Losada   +5 more
wiley   +1 more source

Adenovirus‐Associated Opsoclonus After Allogeneic Hematopoietic Stem Cell Transplantation

eJHaem, Volume 7, Issue 2, April 2026.
Toru Miyajima, Setsuaki Hoshino, Shingo Nojima, Souichi Shiratori, Taishi Iwanami, Takanori Teshima   +5 more
wiley   +1 more source

Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions

MedComm, Volume 7, Issue 3, March 2026.
Immune exhaustion is a well‐established hallmark of both cancer and chronic infection. This review proposes a novel “infection–exhaustion–tumor axis” framework, wherein chronic pathogens (e.g., oncogenic viruses) evade immune surveillance by hijacking inflammatory signaling to drive immune cell exhaustion, thereby creating immunosuppressive niches ...
Yali Song, Yazhi Mo, Si Chen, Yuemei Chen, Chunying Zhang, Shanying Deng, Juan Liao, Yi He, Wei Wang, Weidong Zheng, Tingting Zeng   +10 more
wiley   +1 more source

Varicella Zoster Virus Infection: Clinical Features, Molecular Pathogenesis, Treatment, and Prevention

MedComm, Volume 7, Issue 3, March 2026.
This review focuses on the clinical features, molecular mechanisms, treatment methods, and preventive measures of the VZV, with the aim of providing a theoretical basis for the development of new treatment and prevention methods for HZ. ABSTRACT Varicella zoster virus (VZV) is a ubiquitous human herpesvirus that establishes lifelong latency and causes ...
Lei Peng, Honghao Song, Tianying Li, Yuqing Ma, Chen Yan, Yuhan Cao, Kaiqiang Sun, Chaofeng Han, Hongbin Yuan   +8 more
wiley   +1 more source

Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
This schematic illustrates the central role of lactylation, a lactate‐derived posttranslational modification, in linking metabolic reprogramming to cancer progression and therapy resistance. At its core, lactylation modulates proteins, influenced by metabolic shifts and environmental factors.
Qianying Ouyang, Qianyu Hu, Caiqin Wang, Yizi He, Ruolan Zeng, Yajun Li, Chang Su, Guige Lu, Xueting Zhu, Ling Xiao, Hui Zhou   +10 more
wiley   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Global distribution and contexts of interactions between humans and non‐human primates: A systematic review

People and Nature, Volume 8, Issue 3, Page 551-568, March 2026.
Abstract Understanding the frequency and socio‐ecological drivers of contacts between humans and non‐human primates (NHPs) is crucial for enhancing coexistence that favours NHP conservation, while limiting negative consequences such as aggressions and cross‐species disease transmission.
Cristina Caparrós‐Vallcorba, Filipe Vieira Santos de Abreu, Claudio Azat, Julio A. Benavides   +3 more
wiley   +1 more source

Novel betaherpesviruses and gammaherpesviruses in bats from central China

Scientific Reports
Herpesviruses are large double-stranded DNA viruses that cause infections in animals and humans with a characteristic of latent infectious within specific tissues. Bats are natural hosts of variety human-infecting viruses and recently have been described
Shuhui Duan, Zemin Li, Xu Zhang, Xue-Jie Yu   +3 more
doaj   +1 more source

Genetic diversity and geographic patterns of human herpesvirus 4 and 6

, 2017
This thesis focuses on Human herpesvirus 4 and 6, two ubiquitous viruses with a long list of putative disease associations, ranging from malignancies such as lymphomas and carcinomas to multiple sclerosis. To date, the relatively limited genetic data on these organisms hinders the understanding of their variability and their genetic structure at a ...
openaire   +1 more source