Results 31 to 40 of about 601,020 (224)

Next⁃generation sequencing technology in the diagnosis of five patients with human herpesvirus encephalitis/meningitis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Objective To evaluate the value of next⁃generation sequencing (NGS) of cerebrospinal fluid (CSF) in the diagnosis of human herpesvirus encephalitis/meningitis.
Ke JIN, Xiao-juan WANG, Hong-zhi GUAN, Ling-zhi QIN, Ya-zhen JIA, Ke-ke ZHOU, Hai-chang MA, Yue WANG, Fang WANG, Li XING, Wei LI   +10 more
doaj  

Formation of a DNA triple helical structure at BOLF1 gene of human herpesvirus 4 (HH4) genome

Journal of Biomolecular Structure and Dynamics, 2020
Eukaryotic genomes contain a large number of pyrimidine-purine rich regions and such regions can assume varied DNA conformations, including triple-stranded structures. These structures have fascinated scientists because of their considerable therapeutic applications.
Shikha, Kaushik, Shrikant, Kukreti
openaire   +2 more sources

Inhibition of human herpesvirus 6 replication by 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (2HM-HBG) and other antiviral compounds [PDF]

Antimicrobial Agents and Chemotherapy, 1990
The in vitro susceptibilities of human herpesvirus 6 to foscarnet; the guanosine analogs acyclovir, ganciclovir, and two isomers of 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine; and the thymidine analogs 3'-azido-3'-deoxythymidine and 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil were investigated.
A, Akesson-Johansson, J, Harmenberg, B, Wahren, A, Linde   +3 more
openaire   +2 more sources

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank.

PLoS ONE, 2022
The causes that trigger the onset of dementia are still unknown. Recently there has been an increasing interest in the possible role of infectious agents in the brain in the pathogenesis of this condition.
Krisztina Mekli, Artitaya Lophatananon, Rachel Cant, Alistair Burns, Curtis B Dobson, Ruth F Itzhaki, Kenneth R Muir   +6 more
doaj   +3 more sources

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Infectious mononucleosis, beyond what is seen

Revista Ciencias Biomédicas
Introduction: infectious mononucleosis is an infection caused by various viruses, the most common being the Epstein-Barr Virus, which affects adolescents and young adults.
Danilo Mesa Rincon, Silvia Suárez Mantilla, Claudia Durán Chacón   +2 more
doaj   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

COMPLICATIONS OF INFECTIOUS MONONUCLEOSIS DUE TO EPSTEIN-BARR VIRUS IN CHILDREN AND ADOLESCENTS HOSPITALIZED IN A TERTIARY PEDIATRIC HOSPITAL IN SOUTHERN BRAZIL: A 10-YEAR ANALYSIS (2014‒2024)

Brazilian Journal of Infectious Diseases
Objective: To identify the frequency and types of complications in children and adolescents hospitalized for infectious mononucleosis (IM) caused by Epstein-Barr virus (EBV), as well as possible clinical and laboratory manifestations associated with ...
Isabella Sousa Araujo, Emanuela da Rocha Carvalho   +1 more
doaj   +1 more source

Effect of (r)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) and AZT–lipid–PFA on human herpesvirus-6B infected cells [PDF]

Journal of Clinical Virology, 2009
Human herpesvirus-6 (HHV-6) has been associated with a wide spectrum of diseases. (r)-9-[4-Hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) is an acyclic guanosine analogue that is structurally similar to acyclovir and is in clinical development for treatment of herpesvirus infections. H2G has been found to have activity against HSV type 1, HSV type 2, and
Karen, Yao, Christel, Hoest, Farzin, Rashti, Timm C, Schott, Steven, Jacobson   +4 more
openaire   +2 more sources