Results 31 to 40 of about 627,521 (163)

Additional file 4: of Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6

, 2018
Figure S3. Non-contiguous gel images of silver stain of HHV-6B Z29 lysates in SupT1 cells or serum-free supernatant run on 10-20% TrisHCl gels in MOPS buffer. (PDF 3011 kb)
Greninger, Alexander, Knudsen, Giselle, Roychoudhury, Pavitra, Hanson, Derek, Sedlak, Ruth, Xie, Hong, Guan, Jon, Nguyen, Thuy, Peddu, Vikas, Boeckh, Michael, Huang, Meei-Li, Cook, Linda, Depledge, Daniel, Zerr, Danielle, Koelle, David, Gantt, Soren, Yoshikawa, Tetsushi, Caserta, Mary, Hill, Joshua, Jerome, Keith   +19 more
openaire   +1 more source

Shared genetic and molecular architecture between neurodevelopmental disorders and type 1 diabetes

Journal of Intelligent Medicine, EarlyView.
Abstract Epidemiological and clinical studies have suggested possible associations between type 1 diabetes (T1D) and neurodevelopmental disorders (NDDs), but these relationships remain inconsistent across disorders and populations. To clarify whether such mixed findings, we investigated the genetic architecture linking T1D with autism spectrum disorder
Jingxuan Zhang, Zhentao Zhou, Lirong Zhu, Wei Liu   +3 more
wiley   +1 more source

Prevalence of HCMV, HHV‐6, and HSV‐1/2 in the semen of men attending infertility clinics and their association with semen parameters

UroPrecision, EarlyView.
Abstract Background Viral infections have been identified as potential disruptors of male reproductive health. This study aimed to investigate the prevalence of human cytomegalovirus (HCMV), human herpesvirus 6 (HHV‐6), and herpes simplex virus types 1 and 2 (HSV‐1/2) DNA in semen samples from fertile and infertile men within the potential impact of ...
Seyedeh Zahra Hashemi, Neda Pirbonyeh, Fahime Edalat, Narges Eslami, Saeed Tajik, Arash Letafati, Jamal Sarvari, Afagh Moattari   +7 more
wiley   +1 more source

Alteration of Histone H3 Lysine 4 Trimethylation on Putative Lytic Gene Promoters by Human Set1 Complex during Reactivation of Kaposi’s Sarcoma-Associated Herpesvirus [PDF]

Intervirology, 2013
<b><i>Objective:</i></b> Histone H3 lysine 4 is trimethylated by the human Set1 complex, which regulates the activation of gene expression. The aim of this study was to identify whether the levels of histone H3 lysine 4 trimethylation (H3K4me3) and the recruitment of human Set1 complex at the promoter regions of lytic genes ...
Jae Eun, Jong, Seho, Cha, Jun Hyeong, Jang, Taegun, Seo   +3 more
openaire   +2 more sources

Comprehensive evaluation of metagenomic next‐generation sequencing for pathogen identification in patients with suspected infection: Establishment of a standardized validation workflow

VIEW, EarlyView.
Comprehensive evaluation of metagenomic next‐generation sequencing for pathogen identification in patients with suspected infection: Establishment of a standardized validation workflow. Abstract Metagenomic next‐generation sequencing (mNGS) enables unbiased identification of pathogens directly from clinical specimens. Despite its growing application in
Wen Shu, Qiaomei Guo, Han Yang, Huiqin Jiang, Chunyan He, Xueqing Wang, Yuting Fang, Yue Yin, Liwen Zhong, Zhijing Zhao, Jiatao Lou, Lin Wang   +11 more
wiley   +1 more source

Key insights into biosecurity risks, communication preferences and behaviour change drivers among livestock transporters in Australia

Australian Veterinary Journal, EarlyView.
The transportation of livestock poses an increased risk of disease transmission, with transportation vehicles acting as vectors for disease. Biosecurity management within the livestock industry is therefore critical to reduce the risk of disease transmission. This study investigated the current biosecurity practices of stakeholders within the livestock
M Hernandez‐Jover, L Hayes, J Manyweathers, J Bond   +3 more
wiley   +1 more source

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

Multifocal Epithelioid Hemangioma With FOSB Overexpression

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Epithelioid hemangioma (EH) is a benign vascular tumor that most commonly arises on the skin but may also occur in other anatomical locations, including deep soft tissue, bone, visceral organs, penis, and mucosal sites. A hallmark of EH is overexpression of FOS and FOSB, often resulting from various gene fusions.
Phuong Daniels, Aarush Kumar, Alexa Lum, Izabelle Bermudez, Shannon DeSilva, Jonathan Crane, Kristopher McKay   +6 more
wiley   +1 more source

Clinical and genetic characterization of intellectual disability

Developmental Medicine &Child Neurology, EarlyView.
This study examines the etiological factors and comorbidities in a large cohort of Finnish patients with intellectual disability. Genetic causes—including chromosomal abnormalities and pathogenic gene variants—were more frequently identified in individuals with moderate to profound intellectual disability.
Aarni Venetvaara, Minna Kraatari‐Tiri, Jussi‐Pekka Tolonen, Marko Merikukka, IDGEN Study Group, Hannaleena Kokkonen, Teija Paakkola, Susanna Varis, Antti Dahl, Jarmo Körkkö, Jonna Komulainen‐Ebrahim, Jukka Moilanen, Johanna Uusimaa, Outi Kuismin, Elisa Rahikkala   +14 more
wiley   +1 more source

Outcomes of Kaposi sarcoma in people living with HIV who maintain long‐term viral suppression: A prospective case‐series

HIV Medicine, EarlyView.
Abstract Background Data on chemotherapeutic efficacy and tolerability for Kaposi Sarcomas (KS) in people living with HIV (PWH) and HIV‐virological control are limited. We aimed to describe clinical responses and tolerability of KS therapies in PWH with HIV‐aviraemic KS in a prospective cohort.
S. Bacquart, R. Palich, M. Veyri, S. Bregigeon‐Ronot, M.‐C. Picot, C. Vidal, L. Galicier, S. Choquet, J.‐P. Spano, M.‐A. Valantin, A. Makinson   +10 more
wiley   +1 more source