Results 61 to 70 of about 132,717 (276)

Simultaneous Monitoring Of Cmv And Human Herpesvirus 6 Infections And Diseases In Liver Transplant Patients: One-year Follow-up. [PDF]

, 2015
The aim of this study was to simultaneously monitoring cytomegalovirus and human herpesvirus 6 active infections using nested-polymerase chain reaction and, together with clinical findings, follow the clinical status of patients undergoing liver ...
Andrade, Paula Durante, Boin, Ilka de Fatima, Bonon, Sandra Helena Alves, Cavalcanti, Teresa Cristina, Costa, Fernanda Aparecida, Costa, Sandra Cecília Botelho, Leonard, Luiz Sérgio, Leonard, Marília, Ramos, Marcelo de Carvalho, Rossi, Claudio Lúcio, Sampaio, Ana Maria, Soki, Marcelo Naoki, Stucchi, Raquel Bello, Thomasini, Ronaldo Luis   +13 more
core  

Expert Perspective: Diagnosis and Treatment of Castleman Disease

Arthritis &Rheumatology, Accepted Article.
Summary Castleman disease (CD) is a major diagnostic challenge for Rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Luke Y.C. Chen, Lu Zhang, David C. Fajgenbaum   +2 more
wiley   +1 more source

Physics of Protein Aggregation in Normal and Accelerated Brain Aging

BioEssays, EarlyView.
Soluble monomeric proteins precipitate via nucleation into insoluble amyloids in response to age‐related exposures (e.g., microbes, nanoparticles). Persistent soluble‐to‐insoluble phase transition depletes the functional proteins. In normal aging, replacement matches loss; in accelerated aging, it does not.
Alberto J. Espay, Andrea Sturchio, Alberto Imarisio, Emily J. Hill, Brady Williamson, Kora Montemagno, Christian Hoffmann, Hugo Le Roy, Dragomir Milovanovic, Fredric P. Manfredsson   +9 more
wiley   +1 more source

Statistical properties of thermodynamically predicted RNA secondary structures in viral genomes

, 2008
By performing a comprehensive study on 1832 segments of 1212 complete genomes of viruses, we show that in viral genomes the hairpin structures of thermodynamically predicted RNA secondary structures are more abundant than expected under a simple random ...
A. Tuplin, C. Thurner, D.S.H. Chew, F. Lillo, F. Lillo, F. Lillo, F. Ratcliff, G.P. Schroth, H.O. Smith, J.S. Mattick, M. Spanò, M. Spanò, M.Y. Leung, P. Rice, P. Simmonds, P.E. Warburton, R. Cox, R. N. Mantegna, R.C. Lee, S. Miccichè, S.R. Eddy   +20 more
core   +1 more source

Oxidative stress biomarkers are associated with visible clinical signs of a disease in frigatebird nestlings [PDF]

, 2017
Infectious diseases are one of the most common threats for both domestic and wild animals, but little is known about the effects on the physiological condition and survival of wild animals.
Abd Elgawad, Hamada, Asard, Han, Chastel, Olivier, Costantini, David, de Thoisy, Benoît, Eens, Marcel, Lacoste, Vincent, Pineau, Kévin, Sebastiano, Manrico   +8 more
core   +3 more sources

Developing FGF2 Mutants with Selectively Reduced Heparan Sulfate Affinity to Explore Their Impact on FGFR1 Signaling

ChemBioChem, Accepted Article.
Fibroblast growth factor 2 (FGF2) regulates signal transduction by forming complexes with its receptors, FGF receptors (FGFRs), and heparan sulfate (HS), playing a crucial role in biological systems. Although HS has been suggested to modulate FGF/FGFR signaling as a co‐receptor, multiple hypotheses exist regarding how HS affects FGF/FGFR signaling, and
Yuga Okada, Akihiro Eguchi, Daisuke Kuroda, Kouhei Tsumoto, Ryosuke Ueki, Shinsuke Sando   +5 more
wiley   +1 more source

Herpesvirus 6 Infection and Febrile Seizures

Pediatric Neurology Briefs, 1996
The link between human herpesvirus-6 (HHV-6) and other viruses and febrile convulsions (FC) in 65 children (mean age 18 months) with a first episode of simple FC (Group 1) compared to 24 children (mean age 19 months) with a febrile syndrome without FC ...
J Gordon Millichap
doaj   +1 more source

EHV-1 Pathogenesis: Current in vitro Models and Future Perspectives [PDF]

, 2019
Primary infection and pathogenesis of equine herpesvirus type 1 (EHV-1) require an intricate interaction of virus with the mucosal epithelium, mononuclear cells and the vascular endothelium.
Azab, Walid, Kamel, Mohamed, Osterrieder, Klaus, Pavulraj, Selvaraj   +3 more
core   +1 more source

Targeting Ubiquitin‐Specific Protease 7 with Novel 5‐Amino‐Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation

ChemMedChem, EarlyView.
Ubiquitin‐specific protease 7 (USP‐7) is a novel target for anticancer therapy. To further extend the structure–activity relationships of the previously USP‐7 inhibitor STIRUR‐41, a library of 5‐aminopyrazoles is reported. 1d shows a potency comparable to lead compound STIRUR‐41 and promising in silico and in vitro pharmacokinetic properties ...
Matteo Lusardi, Elva Morretta, Andrea Spallarossa, Maria Chiara Monti, Camillo Rosano, Erika Iervasi, Marco Ponassi, Matteo Mori, Fiorella Meneghetti, Chiara Brullo   +9 more
wiley   +1 more source

Contribution of carbohydrate-related metabolism in Herpesvirus infections

Current Research in Microbial Sciences, 2023
Human herpesviruses are enveloped viruses with double-stranded linear DNA genomes highly prevalent in the human population. These viruses are subdivided into three subfamilies, namely alphaherpesvirinae (herpes simplex virus type 1, HSV-1; herpes simplex
Farías MA, Cancino FA, Navarro AJ, Soto AA, Pastén-Ferrada IA, Carreño LJ, González PA   +6 more
doaj