Results 71 to 80 of about 575,450 (284)

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Sarcoma de Kaposi clássico fatal Fatal outcome in classic Kaposi's sarcoma

Anais Brasileiros de Dermatologia, 2010
Descrito em 1872, o sarcoma de Kaposi é neoplasia multicêntrica rara originária de células endoteliais com manifestação cutânea e extracutânea.
Eugênia Maria Damásio N. Ohe, Maria Helena V. de Q. Padilha, Mílvia M. S. S. Enokihara, Fernando Augusto de Almeida, Adriana Maria Porro   +4 more
doaj   +1 more source

Human Herpesvirus 8--the First Human Rhadinovirus

JNCI Monographs, 1998
Kaposi's sarcoma (KS)-associated herpesvirus, also known as human herpesvirus 8 (HHV-8), is the first known human member of the genus Rhadinovirus. It is regularly found by polymerase chain reaction in all forms of KS, in certain types of Castleman's disease, and in body cavity-based B-cell lymphoma.
Jens-Christian Albrecht, Bernhard Fleckenstein, Frank Neipel   +2 more
openaire   +3 more sources

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, EarlyView.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Prevalence of human herpesvirus 8 antibodies in the population of Belém, Pará, Brazil

Revista do Instituto de Medicina Tropical de São Paulo, 2002
Serum samples from 497 children and adults inhabiting two neighbourhoods (Guamá and Terra Firme) in Belém, Pará, North Brazil were screened for the presence of human herpesvirus 8 (HHV-8) antibody using an enzyme-linked immunosorbent assay. An overall 16.
Ronaldo B. FREITAS, Maria Rute FREITAS, Alexandre C. LINHARES   +2 more
doaj  

Reactivation and Lytic Replication of Kaposi’s Sarcoma-Associated Herpesvirus: An Update

Frontiers in Microbiology, 2017
The life cycle of Kaposi’s sarcoma-associated herpesvirus (KSHV) consists of two phases, latent and lytic. The virus establishes latency as a strategy for avoiding host immune surveillance and fusing symbiotically with the host for lifetime persistent ...
Yan Yuan, Kawalpreet K. Aneja
doaj   +1 more source

Bezlotoxumab as Treatment for Recurrent/Chronic Clostridioides difficile Infection in Pediatric Stem Cell Transplant Recipients: A Multi‐Institutional Experience

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clostridioides difficile infection (CDI) represents a significant health risk to pediatric stem cell transplant (SCT) patients. In these patients, recurrent CDI is common, requiring prolonged antibiotic usage and increased hospitalization. Bezlotoxumab, a monoclonal antibody that targets the toxin responsible for CDI, has demonstrated efficacy
Aaron E. Fan, Shaikha Alqahtani, Natalie Dailey Garnes, Priti Tewari, Demetrios Petropoulos, Sajad Khazal, Kris Mahadeo, Paige DePriest, Irtiza N. Sheikh   +8 more
wiley   +1 more source

Exploring the Hemoglobin T to R2 Path Using Gaussian Elastic Network Correlation Map Distance

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Proteins are dynamic and undergo conformational changes. These changes may affect the motions executed by different regions of the proteins and are reflected in the motion correlation map. A method to accurately measure these changes is presented and exemplified on a set of tetrameric Hemoglobin structures.
Yuval Valenci, Dror Tobi
wiley   +1 more source

Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus

Nature Communications, 2019
Viral control of mitochondrial quality and content has emerged as an important mechanism for counteracting the host response to virus infection. Despite the knowledge of this crucial function of some viruses, little is known about how herpesviruses ...
Mai Tram Vo, Barbara J Smith, J. Nicholas, Y. Choi   +3 more
semanticscholar   +1 more source

A 2‐Min Cytomegalovirus (CMV) Awareness Video Improves Pregnant Women's Knowledge and Planned Adherence to Hygiene Precautions

Australian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.
ABSTRACT Introduction Congenital cytomegalovirus (cCMV) is a leading infectious cause of life‐long neurodevelopmental disabilities, but public awareness of CMV is low. This study evaluated a short educational video on cCMV for its acceptability and impact on pregnant women's knowledge and planned hygiene adherence.
Tanya Tripathi, Jotara Watson, Hayley Smithers‐Sheedy, Kath Swinburn, Natalia Rode, Emma Waight, Annabel Webb, Natasha E. Holmes, Hanako Stump, Antonia Shand, Lisa Hui   +10 more
wiley   +1 more source