Results 51 to 60 of about 582,791 (252)

Epidemiology and fitness effects of wood mouse herpesvirus in a natural host population [PDF]

, 2012
Rodent gammaherpesviruses have become important models for understanding human herpesvirus diseases. In particular, interactions between murid herpesvirus 4 and Mus musculus (a non-natural host species) have been extensively studied under controlled ...
Pedersen, Amy B., Knowles, Sarah L.K., Fenton, Andy   +2 more
core   +1 more source

Machine‐Learning Microfluidic Minute‐Scale Microorganism Metrics Monitoring(M6)

Advanced Science, EarlyView.
ABSTRACT On‐site monitoring of microorganisms remains challenging because of low concentrations, strong background interference, and dynamic aerosol diffusion, particularly for aerosol‐transmitted pathogens. Here, we report a rapid detection platform that integrates a Puri‐focusing microfluidic chip, electrochemical impedance spectroscopy (EIS), and ...
Ning Yang, Jiahao Ding, Si Chen, Lijie Yan, Shichao Ding, Lavonda Li, Junyi Sun, Haodong Liu, Tongge Li, Ning Liu, Mingji Wei, Xiaoyong Zhu, Xiaobo Zou, Shouqi Yuan, Xingcai Zhang   +14 more
wiley   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Human Herpesvirus 8: Current Issues [PDF]

Clinical Infectious Diseases, 2003
Although human herpesvirus 8 (HHV-8) is the etiologic agent of Kaposi sarcoma (KS), there are no formal guidelines for the clinical management of HHV-8 infection. In patients infected with human immunodeficiency virus (HIV), highly active antiretroviral therapy (HAART) is the best tool for the prevention of KS.
Michael J, Cannon, A Scott, Laney, Philip E, Pellett   +2 more
openaire   +2 more sources

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

Non-detection of human herpesvirus 8 (HHV-8) DNA in HHV-8-seropositive blood donors from three Brazilian regions. [PDF]

, 2011
Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), is the etiologic agent of all forms of Kaposi's sarcoma, primary effusion lymphoma and the plasmablastic cell variant of multicentric Castleman disease. In endemic
de Souza Vanda Akico Ueda Fick, Sumita Laura Masami, Nascimento, Maria Claudia do, FREIRE, Wilton S., Nascimento, Maria Claudia, SOUZA, Vanda Akico Ueda Fick de, Claudio S Pannuti, Mayaud Philippe, Pannuti Claudio S., Vanda Akico Ueda Fick de Souza, Wilton S. Freire, Wilton S Freire, Freire Wilton S., PANNUTI, Claudio S., Levi, José Eduardo, Maria Claudia Nascimento, de Souza, Vanda Akico Ueda Fick, Nascimento Maria Claudia, Pannuti, Claudio S, Mayaud, Philippe, Freire, Wilton S, Levi José Eduardo, Laura Masami Sumita, Philippe Mayaud, Claudio S. Pannuti, Sumita, Laura Masami, José Eduardo Levi   +26 more
core   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Short communication: NKG2C+ NK cells contribute to increases in CD16+CD56- cells in HIV type 1+ individuals with high plasma viral load. [PDF]

, 2013
Chronic HIV-1 infection results in the expansion of both NKG2C+ and CD16+CD56- human natural killer cells. NKG2C+ cells proliferate in response to human cytomegalovirus (HCMV) and expansion of the dysfunctional CD56-CD16+ natural killer (NK) cells is ...
Gregson, John NS, Gazzard, Brian G, Goodier, Martin R, Kuri-Cervantes, Leticia, Mela, Christopher M, Bower, Mark   +5 more
core   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, EarlyView.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

Cytomegalovirus replicon-based regulation of gene expression in vitro and in vivo [PDF]

, 2011
There is increasing evidence for a connection between DNA replication and the expression of adjacent genes. Therefore, this study addressed the question of whether a herpesvirus origin of replication can be used to activate or increase the expression of ...
Mohr, Hermine, Eckhard Wolf, Marlon R. Schneider (160130), Ulrich H Koszinowski, Laura Scrivano (160134), Eckhard Wolf (39870), Koszinowski Ulrich H., Ruzsics, Zsolt, Schnieke Angelika, Christian A. Mohr (160123), Ulrich H. Koszinowski (152143), Marlon R. Schneider, Mohr Hermine, Schneider Marlon R., Dahlhoff, Maik, Hermine Mohr (160119), Zsolt Ruzsics (75383), Simone Kraner-Schreiber, Schneider, Marlon R., Christian A Mohr, Laura Scrivano, Kraner-Schreiber, Simone, Maik Dahlhoff, Simone Kraner-Schreiber (160141), Ruzsics Zsolt, Maik Dahlhoff (160144), Adler Barbara, Koszinowski, Ulrich H., Kraner-Scheiber, Simone, Zsolt Ruzsics, Mohr, Christian A., Kraner-Schreiber Simone, Schnieke, Angelika, Adler, Barbara, Wolf Eckhard, Dahlhoff Maik, Barbara Adler, Ulrich H. Koszinowski, Christian A. Mohr, Mohr Christian A., Scrivano Laura, Wolf, Eckhard, Hermine Mohr, Marlon R Schneider, Scrivano, Laura, Angelika Schnieke (133290), Barbara Adler (160138), Angelika Schnieke   +47 more
core   +1 more source