The Spectrum of Epidermolysis Bullosa in KwaZulu‐Natal, South Africa
ABSTRACT Background Epidermolysis bullosa (EB) is a rare, heterogeneous genodermatosis characterized by skin fragility due to inherited defects in genes encoding proteins that maintain epidermal–dermal integrity. The severity and complications of EB vary by subtype, and no cure currently exists. The epidemiology is unknown in South Africa. Methods This
Antoinette Chateau+10 more
wiley +1 more source
Hypercalcemia as a rare manifestation of immune reconstitution inflammatory syndrome (IRIS) in a person living with Human Immunodeficiency Virus (HIV) with disseminated nontuberculous mycobacteriosis. [PDF]
Webendoerfer M+10 more
europepmc +1 more source
Sketching T cell atlases in the single‐cell era: challenges and recommendations
Recent advances in single‐cell technologies have enabled the creation of T cell atlases, providing detailed maps of adaptive immunity across tissues, development and disease states. These atlases help uncover T cell diversity, functional states and disease mechanisms, aiding in the identification of therapeutic targets.
Itana Bojović+3 more
wiley +1 more source
Abstract Background and Aim Varicella zoster virus (VZV) is a neurotropic herpesvirus. With improved access to molecular diagnostics, there is increasing recognition of VZV with central nervous system involvement. This study aimed to describe the demographic, clinical and treatment characteristics of patients admitted to an Australian tertiary hospital
Connie Lam+6 more
wiley +1 more source
Human Herpesvirus-8 (HHV-8)-Positive Human Immunodeficiency Virus (HIV)-Negative Multicentric Castleman Disease With a Fulminant Course. [PDF]
Brito MT+4 more
europepmc +1 more source
Leprosy, a chronic infectious disease caused by Mycobacterium leprae, manifests in a spectrum of clinical forms and severity. This study investigated the percentage of CD8+ T cells and their subpopulations (CD8bright and CD8dim T cells) in leprosy patients stratified by clinical forms, bacterial load, and age.
Yuri Scheidegger de Castro+7 more
wiley +1 more source
Prevalence and Treatment Outcomes of Syphilis among People with Human Immunodeficiency Virus (HIV) Engaging in High-Risk Sexual Behavior: Real World Data from Northern Greece, 2019-2022. [PDF]
Nanoudis S+11 more
europepmc +1 more source
Flagellins as Vaccine Adjuvants and Cancer Immunotherapy: Recent Advances and Future Prospects
The figure depicts the role of flagellin in immune cells. Flagellin interacts with TLR5, resulting in the formation of homodimers and the recruitment of MyD88, which activates the IκB and MAPK signalling pathways. This results in the activation of NF‐κB and AP‐1, producing TNF‐α, IL‐6, IL‐8, and IL‐12.
Asma Talukder+4 more
wiley +1 more source
Cancer risk among people living with Human Immunodeficiency Virus (HIV) in Rwanda from 2007 to 2018. [PDF]
Dusingize JC+11 more
europepmc +1 more source
Should We Advance Our Understanding of Immunoglobulin E in Viral Immunity?
Immunoglobulin E has been extensively studied in allergies and parasitic diseases. Antigen‐specific IgE has been identified as part of the humoral response to viruses. This revision speculates on possible functionalities for IgE, such as neutralisation, cytotoxicity and immunopathology of viral diseases, and provide insights about gaps to fill in ...
Amanda Izeli Portilho+3 more
wiley +1 more source