Results 71 to 80 of about 497,503 (208)

Failure of dideoxynucleosides to inhibit human immunodeficiency virus replication in cultured human macrophages. [PDF]

, 1987
Primary human monocyte-derived macrophages (MDM) were shown to have diminished deoxynucleoside kinase activities compared to T lymphoblasts, and a reduced ability to phosphorylate dideoxynucleosides with anti-human immunodeficiency virus (HIV) activity ...
Carson, DA, Kornbluth, RS, Richman, DD
core  

Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants [PDF]

, 2014
Antibody-mediated immunotherapy is effective in humanized mice when combinations of broadly neutralizing antibodies (bNAbs) are used that target nonoverlapping sites on the human immunodeficiency virus type 1 (HIV-1) envelope.
Almond, Anna Gazumyan, Anthony P. West, Ariel Halper-Stromberg, Baenziger, Balazs, Barouch, Blish, Bosch, Bunnik, Burke, Cassie Liu, Clara Lehmann, Constance Williams, Doria-Rose, Florian Klein, Ganesh Phad, Gaufin, Gaufin, Gerd Fätkenheuer, Gunilla B. Karlsson Hedestam, Hioe, Horwitz, Huang, Jiang, Joshua A. Horwitz, Klein, Klein, Koch, Li, Lilian Nogueira, Ly, Malcolm A. Martin, Masashi Shingai, McCaffrey, McGuire, Michael S. Seaman, Michel C. Nussenzweig, Miller, Moldt, Mouquet, Mouquet, O’Rourke, Pamela J. Bjorkman, Pietzsch, Pietzsch, Pinter, Scheid, Scheid, Schmitz, Seaman, Shingai, Shingai, Simek, Sundling, Sundling, Sundling, Susan Zolla-Pazner, Thomas R. Eisenreich, Totrov, Walker, Walker, Wei, Yang, Yoshiaki Nishimura, Zhang, Zolla-Pazner, Zolla-Pazner   +67 more
core   +1 more source

The Human Immunodeficiency Virus - a Review of the clinical aspects and detection of the infection

Quality in Sport
Introduction: Currently, many people are infected with the human immunodeficiency virus (HIV). Transmission is primarily through sexual contact, with additional routes including mother-infant exposure to needles and needle sharing.
Martyna Choinka, Agata Konopka, Natalia Wdowiak, Zuzanna Szczepaniak, Jakub Kalisiak, Anna Szpernalowska, Vimbisoyashe Ivy Matshaba, Karolina Mrugała   +7 more
doaj   +1 more source

Characterization Of Recombinant Antibodies Targeting Hiv-1 Capsid Protein (P24): Towards The Development Of Antibody-Based Therapy Against Hiv/Aids [PDF]

, 2017
Virus imunodifisiensi manusia (HIV) adalah agen penyebab sindrom kurang daya tahan terhadap penyakit (AIDS). Peningkatan morbiditi dan kematian akibat HIV/AIDS dalam beberapa dekad kebelakangan ini telah mencetuskan perhatian untuk memerangi penyakit ...
Mualif, Siti Aisyah
core  

Interactions in vivo between the Vif protein of HIV-1 and the precursor (Pr55GAG) of the virion nucleocapsid proteins [PDF]

, 2009
The abnormality of viral core structure seen in vif-defective HIV-1 grown in PBMCs has suggested a role for Vif in viral morphogenesis. Using an in vivo mammalian two-hybrid assay, the interaction between Vif and the precursor (Pr55GAG) of the virion ...
A Harmache, A Mehle, AM Borman, AM Sheehy, AM Sheehy, B Liu, B Liu, B Mangeat, C Tian, DH Gabuzda, DH Gabuzda, Farhatullah Syed, H Ochman, H Zhang, HA Vasavada, I Sadowski, JH Simon, K Luo, K Stopak, L Baraz, L Fan, M Bouyac, M Bouyac, M Boyce, M Marin, MA Adekale, Malcolm A. McCrae, MS Oberste, N Madani, RA Fouchier, RC Desrosiers, RS Harris, S Cen, S Erickson-Viitanen, S Hoglund, SG Conticello, SK Arya, TH Lee, X Yu, Y Gluzman, Y Imai, Y Yu, YH Zheng   +42 more
core   +1 more source

Human immunodeficiency virus prevention and testing strategies among men who have sex with men in the UK: the PANTHEON research programme including the SELPHI RCT

Programme Grants for Applied Research
Background Rates of human immunodeficiency virus diagnoses in UnitedKingdom men who have sex with men were at a 10-year high in 2014; many recent infections indicated ongoing transmission. There was a need to increase testing rates, reduce late diagnosis
Janey Sewell, T Charles Witzel, David Dunn, Fiona Lampe, Fiona Burns, Peter Weatherburn, Sheena McCormack, Leanne McCabe, Alec Miners, Valentina Cambiano, Roger Pebody, Roy Trevelion, Nadia Hanum, Andrew Phillips, Alison Rodger   +14 more
doaj   +1 more source

Understanding the process of envelope glycoprotein incorporation into virions in simian and feline immunodeficiency viruses [PDF]

, 2014
The lentiviral envelope glycoproteins (Env) mediate virus entry by interacting with specific receptors present at the cell surface, thereby determining viral tropism and pathogenesis.
Affranchino, Jose Luis, Gonzalez, Silvia Adriana   +1 more
core   +4 more sources

Dimerisation of HIV-2 genomic RNA is linked to efficient RNA packaging, normal particle maturation and viral infectivity. [PDF]

, 2007
BACKGROUND: Retroviruses selectively encapsidate two copies of their genomic RNA, the Gag protein binding a specific RNA motif in the 5' UTR of the genome.
Andrew ML Lever (60785), Anne L'Hernault (60782), Jane S Greatorex (60783), R Anthony Crowther (60784)   +3 more
core   +3 more sources

The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template

Cell Reports, 2019
Summary: Epitope-targeted HIV vaccine design seeks to focus antibody responses to broadly neutralizing antibody (bnAb) sites by sequential immunization.
Raiees Andrabi, Jesper Pallesen, Joel D. Allen, Ge Song, Jinsong Zhang, Natalia de Val, Gavin Gegg, Katelyn Porter, Ching-Yao Su, Matthias Pauthner, Amanda Newman, Hilary Bouton-Verville, Fernando Garces, Ian A. Wilson, Max Crispin, Beatrice H. Hahn, Barton F. Haynes, Laurent Verkoczy, Andrew B. Ward, Dennis R. Burton   +19 more
doaj   +1 more source

HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors [PDF]

, 2005
RNA and DNA aptamers specific for HIV-1 reverse transcriptase (RT) can inhibit reverse transcription in vitro. RNA aptamers have been shown to potently block HIV-1 replication in culture.
Fisher, Timothy S, Joshi, Pheroze, Prasad, Vinayaka R   +2 more
core   +3 more sources