Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Correction: Human impact on the recent population history of the elusive European wildcat inferred from whole genome data. [PDF]
BMC Genomics, 2023 Nieto-Blázquez ME +5 more
europepmc +1 more source
The analysis and evaluation of the relation between road transportation and climate change [PDF]
, 2007 The target of this article is to analyse and evaluate the relation between road transportation and climate change, through the long time series of average CO2 concentration in the atmosphere and global average temperature of Earth.
Török, Ádám
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
The human impact of commercial delivery cycling injuries: a pilot retrospective cohort study. [PDF]
Pilot Feasibility Stud, 2022 Sarkies MN +8 more
europepmc +1 more source
Accumulation of Human Capital and FDI Inflows in ASEAN-3 Countries (Malaysia, Thailand, Indonesia) [PDF]
The event of globalization and the increasing inflows of FDI to developing countries create a potential for technology transfers and spillovers which suggest a potential for future growth of human capital, and output.
Heirsh SOLTANPANAH +1 more
core
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Human impact on the recent population history of the elusive European wildcat inferred from whole genome data. [PDF]
BMC Genomics, 2022 Nieto-Blázquez ME +5 more
europepmc +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The Human Impact on All Soil-Forming Factors during the Anthropocene. [PDF]
ACS Environ Au, 2022 Dror I, Yaron B, Berkowitz B.
europepmc +1 more source