Results 71 to 80 of about 2,869,907 (257)
Studia Universitatis Babeș-Bolyai. BiologiaRoads are in permanent expansion at the global level and have numerous negative effects, impacting even the litter-dwelling invertebrates from their vicinity.
Sára FERENȚI +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Dünya Coğrafyası ve Kalkınma Perspektifi Dergisiİnsan faaliyetlerinin doğal koşullardaki baskı ve etki boyutlarının artması, jeomorfolojik unsurlarda da değişimlere yol açmaktadır. Bu çalışmada Muğla ilinin kuzey ve batısındaki 6 ilçe kapsamında zamansal ve mekânsal açıdan farklı kriterler ...
Selin Apatarkan +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Rewiring the Evaluation Marketplace for a Changing World
Journal of MultiDisciplinary EvaluationThis issue of JMDE asks how evaluation should respond to the transformational imperative to contribute to the radical changes essential for a regenerative, socially just, and equitable future for humanity and the planet.
Nancy MacPherson +2 more
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Miscellanea Geographica: Regional Studies on DevelopmentThis study investigates the impact of river engineering on the morphometry of the Vistula River channel near Warsaw, Poland, over a 172-year period. This research focuses on the examination of modifications in the Vistula channel between 1843 and 2015 ...
Poławska Martyna, Giriat Dorota
doaj +1 more source