Results 81 to 90 of about 8,254,808 (300)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Dünya Coğrafyası ve Kalkınma Perspektifi Dergisiİnsan faaliyetlerinin doğal koşullardaki baskı ve etki boyutlarının artması, jeomorfolojik unsurlarda da değişimlere yol açmaktadır. Bu çalışmada Muğla ilinin kuzey ve batısındaki 6 ilçe kapsamında zamansal ve mekânsal açıdan farklı kriterler ...
Selin Apatarkan +2 more
doaj +1 more source
Aid, Conflict and Human Development [PDF]
A large and growing literature addresses the impact of foreign aid on the growth of per capita incomes in recipient countries. While this link is important, given its implications for poverty reduction, an arguably more important link is that between aid
Farhad Noorbakhsh, Mark McGillivray
core
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Human capital—economic growth nexus in the former Soviet Bloc [PDF]
This study analyses the role of education in economic development in the republics of the former Socialist Bloc and more specifically the impact of human capital on per capita economic growth in transition economies in the Russian Federation, and Ukraine.
Osipian, Ararat
core +1 more source
A Smart Investment in Human Capital: How AchieveMission Helped the Corporation for Supportive Housing Increase Mission Impact [PDF]
, 2013 This report examines the work of AcheiveMission as it helped The Corporation for Supportive Housing to completely re-think how it attracts, places, supports and key staff and manages human capital to improve mission ...
core
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source