Results 141 to 150 of about 8,123,417 (252)

Montane rainforest dynamics under changes in climate and human impact during the past millennia in northern Madagascar. [PDF]

R Soc Open Sci
Montade V, Bremond L, Teixeira H, Kasper T, Daut G, Rouland S, Rasoamanana E, Ramavovolona P, Favier C, Arnaud F, Radespiel U, Behling H.   +11 more
europepmc   +1 more source

Women's and Children's Health: Evidence of Impact of Human Rights [PDF]

, 2013
Bustreo, Flavia, Eide, Asbjorn, Ferguson, Laura, Gruskin, Sofia, Halliday, Emma, Hunt, Paul, Kuruvilla, Shyama, McGoey, Linsey, Popay, Jennie, Rao, Sujatha, Sander, Genevieve, Songane, Francisco, Tarantola, Daniel, Unnithan, Maya, van Bolhuis, Annemiek, Yamin, Alicia Ely   +15 more
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Human Impact on the Twenty-Four-Hour Patterns of Steller Sea Lions' Use of a Haulout in Hokkaido, Japan. [PDF]

Animals (Basel)
Chayahara Y, Nakanowataru Y, Abe S, Kurosawa R, Suma S, Murasato N, Oyamada R, Ebashi N, Tsunokawa M, Sakurama M, Kooriyama T.   +10 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Bird populations and species lost to Late Quaternary environmental change and human impact in the Bahamas. [PDF]

Proc Natl Acad Sci U S A, 2020
Steadman DW, Franklin J.
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Metagenomic survey of antimicrobial resistance (AMR) in Maryland surface waters differentiated by high and low human impact. [PDF]

Microbiol Resour Announc
Kocurek B, Behling S, Martin G, Ramachandran P, Reed E, Grim C, Mammel M, Zheng J, Franklin A, Garland J, Tadesse DA, Sharma M, Tyson GH, Kabera C, Tate H, McDermott PF, Strain E, Ottesen A.   +17 more
europepmc   +1 more source