Results 51 to 60 of about 8,123,417 (252)
Stop and Frisk: The Human Impact [PDF]
, 2012 The New York City Police Department's (NYPD's) aggressive stop-and-frisk practices are having a profound effect on individuals, groups and communities across the city.
Nahal Zamani, Sarah Hogarth
core
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Socioeconomic, Institutional & Political Determinants of Human Rights Abuse: A Subnational Study of India, 1993-2002 [PDF]
, 2008 We conduct an econometric analysis of socioeconomic, institutional and political factors determining government respect for human rights within India.
Vadlamannati, Krishna Chaitanya
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Human exposure in low Earth orbit [PDF]
Human exposure to trapped electrons and protons in low Earth orbit (LEO) is evaluated on a basis of a simple approximation of the human geometry for spherical shell shields of varying thickness.
Cucinotta, F., Wilson, J. W.
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The American Biology Teacher, 2018 Earth in Human Hands: Shaping Our Planet's Future . By David Grinspoon. 2016. Grand Central Publishing. (ISBN 9781455589128). 522 pages. Hardcover. $28.00. Dr. Grinspoon's massive review of Earth's past, present, and future begins with a nod to the Anthropocene and the idea that humans, with regard to the state of the planet, are “at the controls ...
openaire +2 more sources